Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
Harvard
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GLP1s looking more and more like longevity drugs
New paper @Nature: Semaglutide recapitulates many of the benefits of caloric restriction in female mice & extends lifespan by almost 100 days. Males not yet tested for lifespan
Below: Red traces = mouse movement
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Exercise is not punishment for what you ate. It is an investment in the life you still want to live.
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Walk when you can. Lift something heavy. Occasionally get out of breath. Your older self will thank you.
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Every workout is a message to your body: stay strong, stay capable, stay young.
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Good health isn’t built through a few giant acts. It is built through ordinary choices made consistently
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Arterial calcification is not just the accumulation of cholesterol. It is an active biological program in which vascular cells begin behaving like bone-forming cells and they start building bone. Could loss of epigenetic information be pushing them to forget what they are?
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David Sinclair retweeted
In honor of World Alzheimer's Day, new science - and new reasons for hope.
Made with AI
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David Sinclair retweeted
Honored to have physician and @Microsoft Chief Medical Officer @drhew share his perspective in the September issue of Lifespan Magazine on how AI can help us age well.
From ambient voice technology and wearables to healthcare access, trustworthy AI, and what the future of care could look like, we covered a lot of ground. Read now in Lifespan Magazine by @kellygenetics
lifespan.com/blogs/magazine/…
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Stem cells don't run out, they get told to stop dividing and that instruction can be renegotiated
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This amino is my favorite. It is found in asteroids and is as sweet as sugar! Trust me, my PhD is on it
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Important
Having a reason to get up in the morning cuts your risk of dying by more than half. A 2019 JAMA study of nearly 7,000 adults found that people with the strongest sense of purpose had the lowest mortality, and the effect was independent of wealth, health, exercise, and depression.
Purpose does not mean ambition. It means feeling that your daily actions matter to something beyond yourself. A grandparent raising a garden. A retired teacher who tutors. A caregiver who shows up every morning. The research does not measure achievement. It measures the feeling that what you do connects to something.
The biological pathway runs through every system the body uses to stay alive. People with a sense of purpose sleep better, have lower inflammatory markers, take their medications, show up for screenings, and maintain social ties. Each of those individually lowers mortality. Together, they compound into a survival advantage that is larger than the sum of its parts.
The opposite is also in the data. People who lose purpose, through retirement without a replacement, the death of a spouse, or the end of a career they defined themselves by, show a rapid decline in health that cannot be explained by aging alone. The body seems to treat purposelessness as a signal that the organism is no longer needed.
Nobody writes "sense of purpose" on a prescription pad. The research says it belongs there. pubmed.ncbi.nlm.nih.gov/3112…
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We must do better.
"Death is now less often sudden and more often preceded by prolonged periods of decline characterized by multimorbidity. This ‘slow dying’ has profound implications"
Let's target aging, the cause, not the symptoms
onlinelibrary.wiley.com/doi/…
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