We have now published @MCBJournal our secondary-structure model for the 1212 nt ๐˜š. ๐˜ฑ๐˜ฐ๐˜ฎ๐˜ฃ๐˜ฆ telomerase RNA, derived largely from bioinformatic and phylogenetic analyses of genomic data. Furthermore, our ๐˜ช๐˜ฏ ๐˜ท๐˜ช๐˜ท๐˜ฐ studies: (1) map TER1 RNA's functionally important domains vs. dispensable regions (2) show that the three-way junction can be repositioned in the RNA while still providing its essential function. These findings regarding the fission-yeast telomerase RNA are reminiscent of what we have found in the *evolutionarily distant* organism ๐˜š. ๐˜ค๐˜ฆ๐˜ณ๐˜ฆ๐˜ท๐˜ช๐˜ด๐˜ช๐˜ข๐˜ฆ. Overall, studying telomerase RNP in yeasts continues to advance our understanding of the RNA world, while also getting us closer to cancer- and aging-inhibiting interventions. tandfonline.com/doi/full/10.โ€ฆ @LehighU @Lehigh_CAS @BioLehigh @tandfonline
2
5
145
Here are some of the prior papers regarding telomerase RNA and its role as a flexible scaffold in the RNP complex: pubmed.ncbi.nlm.nih.gov/?terโ€ฆ

Nov 30, 2025 ยท 4:34 PM UTC

25
Sort replies: Relevant Recent Liked