We have now published @MCBJournal our secondary-structure model for the 1212 nt ๐. ๐ฑ๐ฐ๐ฎ๐ฃ๐ฆ telomerase RNA, derived largely from bioinformatic and phylogenetic analyses of genomic data.
Furthermore, our ๐ช๐ฏ ๐ท๐ช๐ท๐ฐ studies:
(1) map TER1 RNA's functionally important domains vs. dispensable regions
(2) show that the three-way junction can be repositioned in the RNA while still providing its essential function.
These findings regarding the fission-yeast telomerase RNA are reminiscent of what we have found in the *evolutionarily distant* organism ๐. ๐ค๐ฆ๐ณ๐ฆ๐ท๐ช๐ด๐ช๐ข๐ฆ.
Overall, studying telomerase RNP in yeasts continues to advance our understanding of the RNA world, while also getting us closer to cancer- and aging-inhibiting interventions.
tandfonline.com/doi/full/10.โฆ
@LehighU @Lehigh_CAS @BioLehigh @tandfonline
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Here are some of the prior papers regarding telomerase RNA and its role as a flexible scaffold in the RNP complex: pubmed.ncbi.nlm.nih.gov/?terโฆ
Nov 30, 2025 ยท 4:34 PM UTC
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