Our new paper presents a metabolic manifesto that can help curb the current epidemic of chronic diseases and cancer. We show how mitochondrial dysfunction is the root of many chronic diseases and most major cancers (
doi.org/10.3389/fsci.2026.17…). A quantitative scale of glucose ketone index (GKI) values linked to color-coded zones of health provides a cohesive readout for increasing adherence and reducing risk of chronic disease and cancer. Low GKI values can improve mitochondrial function thus reducing risk, while high GKI values can compromise mitochondrial function thus increasing risk. The GKI, used together with science-based nutrition and exercise, represents a novel therapeutic strategy for improving mitochondrial health regardless of age, gender, or genetic predisposition.