Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and...

Pain affects one in five women with PMOS, with pronounced racial disparities and meaningful reduction following targeted medical treatment.

Pre-Cambrian origin of envelope-carrying retrotransposons in metazoans

Envelope-carrying Ty3/gypsy LTR retrotransposons are ancient and widespread across animals, revealing deep evolutionary links between retroelements, viral fusogens, and retroviruses.

Dynamic fMRI networks of human emotion

Time-resolved mapping of whole-brain functional MRI networks during human emotional experience reveals a dynamic systems-level organization that links temporal processing with large-scale functional...

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid...

SETD6-mediated methylation of PPARγ establishes a positive feedback mechanism that enhances transcriptional activation and promotes hepatic lipid accumulation.

Systematic analysis of network-driven adaptive resistance to CDK4/6 and oestrogen receptor inhibi...

Meta Dynamic Network analysis can identify the capacity of a network to facilitate adaptive drug resistance and the respective underlying mechanistic causes.

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidif...

Restoring endolysosomal membrane fluidity limits tau seed escape, seeded aggregation, and neuronal toxicity in cell and animal models.

A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.

Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability...

The Z-disc of muscle sarcomeres is a solid aggregate stabilized by the intrinsically disordered region of the Alp/Enigma family protein Zasp52.

Publishing in the eLife Model: An author’s perspective

Hear from some of our authors about their experience of publishing with us.

Evolution of sideways locomotion in crabs

Sideways locomotion in true crabs likely originated once from a forward-moving ancestor, providing insight into how behavioral innovations shape evolutionary diversification.

Top-down feedback in deep neural networks leads to functional differences during audiovisual...

Gain-modulating top-down feedback introduces behavioral differences between otherwise identical neural networks, particularly in a network with connectivity based on the human brain, which displays a...

Perceiving animacy in ‘identical’ images

Visual anagrams, images whose interpretations change with orientation, isolate visual processing of animacy itself, beyond its lower-level correlates.

Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless...

A lamprey KCNE protein provides insight into the early evolution of vertebrate potassium-channel regulation.

Adaptive behavior is guided by integrated representations of controlled and non-controlled inform...

Controlled and non-controlled information are simultaneously encoded within an integrated representation in partially overlapping neural subspaces, and the strengths of both representations jointly...

A membrane insertion code for intrinsically disordered proteins

A sequence-based method dubbed AroMIP predicts the membrane insertion propensities of aromatic-centered motifs, thereby advancing mechanistic understanding of membrane insertion and enriching the...

Optimising the tilt increment for in situ cryo-electron tomography

For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.

Correction: p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative...

Crickets evade bats via olfaction beyond acoustic cues

Olfactory bat avoidance in crickets uncovers an overlooked sensory axis in this classic system and a functional eavesdropping strategy across phylogenetically distant predator–prey interactions.

Heterogeneity of use, access, and retention of insecticide-treated nets: Implications for subnati...

While transmission intensity should still drive where insecticide-treated nets are prioritised, deprioritising areas where people are more likely to use nets may cause larger case resurgences than...