PhD at Molecular Metabolism CiMUS/IDIS
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🌞 It’s summer, and from the Molecular Metabolism group we’re contributing to your summer reading with a fresh new paper! 📚
Our latest study, “Resmetirom Ameliorates Fibrogenesis in HSC”, uncovers a new mechanism through which resmetirom may directly modulate liver fibrosis.
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We think that this work opens new questions about targeting thyroid hormone signaling in HSCs as a strategy against liver fibrosis.
If you want to see more: onlinelibrary.wiley.com/doi/…
#MASH #MASLD #LiverFibrosis #Resmetirom #Hepatology
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And, of course, science is always a team effort. ❤️
A huge thank you to everyone who contributed to this work, both within and beyond the Molecular Metabolism group.
And a very special thank you to @CabaleiroAlba , my eternal companion in science. 🫶
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Hoy, en el Día de la Mujer Trabajadora, salimos en el periódico. Un orgullo compartir este logro y seguir avanzando en ciencia.
Gracias especialmente a mi compañera @ParrachoTamara por su trabajo, esfuerzo y dedicación 💜🔬
lavozdegalicia.es/noticia/la…
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We are back!! I'm excited to share our new paper from @RubenNogueiras lab at @cimususc , where we identified the key role of PCK1 in liver fibrosis progression. Key findings below...👇
New! Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis dlvr.it/TR6mSR
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So, PCK1 protects the liver from scarring by keeping fibrogenic cells in a quiescent state. When PCK1 is reduced, these cells undergo metabolic reprogramming characterized by increased glycolysis, become aberrantly activated, and promote liver fibrosis in mice.
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Finally, this work wouldn't have been possible without our entire lab team and collaborators, but special thanks to @ParrachoTamara and @ChusaGzlzRellan for driving this project to success! 🔬
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I'm excited to share the findings from our recent study from @RubenNogueiras lab, where we investigated whether GLP-1 and GIP agonists have direct actions on human hepatocytes and hepatic stellate cells (HSCs)... Here is a brief summary of the newest findings...👇
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This work wouldn’t have been possible without the entire lab team, but I especially want to thank @CabaleiroAlba and Natalia for making this project a success. 🙌
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🔍 For more details, check out the full article here: link.springer.com/article/10…
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