Human vs Brain
@humanvsbrain

Neuroscience × browser games 🧠 Can you beat 166,700 biological neurons? Built on the MaleCNS fruit-fly connectome.

humanvsbrain.com
Joined September 2026
3 Photos and videos
Human vs Brain is live. 🪰🧠 Can you beat 166,700 biological neurons? First game and first brain is out. 10 rounds. 900 ms to react. You race a computational model constrained by the mapped MaleCNS connectome of an adult fruit fly. Play → humanvsbrain.com

Human vs Brain — Can You Beat 166,700 Biological Neurons?

Play a 10-round reaction game against a computational model based on the mapped 166,700-neuron MaleCNS connectome of an adult male Drosophila central nervous system.

humanvsbrain.com
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Human vs Brain now has persistent plasticity. The MaleCNS-derived network keeps its anatomy fixed, but 300 existing synapses near the DNa02 LEFT/RIGHT output can change strength through experience. After 10,000 controlled trials: Accuracy: 93.75% → 94.05% RIGHT accuracy: 87.5% → 88.1% LEFT accuracy: 100% → 100% Median neural decision latency: 840 ms → 820 ms No new neurons. No new edges. No topology changes. Next question: can repeated experience make the same fixed connectome reach correct decisions progressively earlier? humanvsbrain.com

Human vs Brain — Can You Beat 166,700 Biological Neurons?

Play a 10-round reaction game against a computational model based on the mapped 166,700-neuron MaleCNS connectome of an adult male Drosophila central nervous system.

humanvsbrain.com
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Everytime someone plays a game, the connectome "learns" a little. Or not. That's the experiment. More games to follow. The goal is to make the whole site connected by the same connectome.
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New targets for game 1. There is one easter egg target (or two). If you find them post here. There is a reward for you.
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screenshot*
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Human vs Brain retweeted
Cryptome@Crypto_me
Sep 23
I raced a fruit-fly brain simulation 🪰🧠 Human 8 — 2 Brain 10 rounds. 900 ms to react. Think you're faster? humanvsbrain.com

Human vs Brain — Can You Beat 166,700 Biological Neurons?

Play a 10-round reaction game against a computational model based on the mapped 166,700-neuron MaleCNS connectome of an adult male Drosophila central nervous system.

humanvsbrain.com
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Human vs Brain retweeted
Human vs Brain
@humanvsbrain
Sep 22
Can you beat these tiny insects? A fruit fly is only a few millimetres long. Give one a rotten apple and 25 days, and things escalate quickly. And inside that tiny head is a nervous system we can now map and and play against. Human vs Brain.
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Could a connectome-powered fruit fly sleep, get lost in the dark, and escape a threat? 🪰🧠 The biology behind those behaviours is real: • looming escape circuits via LC4/LPLC2 → Giant Fiber • heading representation in the central complex • circadian PER oscillations • sleep/homeostatic regulation The interesting part is combining real neural wiring with simplified dynamics and testing what behaviour emerges. Not a digital fly. Not a complete brain simulation. A computational experiment built from real neural circuitry.
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Slightly better visuals and performance on game 1. Game 2 under development.
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Human vs Brain retweeted
Human vs Brain
@humanvsbrain
Sep 19
humanvsbrain.com

Human vs Brain — Can You Beat 166,700 Biological Neurons?

Play a 10-round reaction game against a computational model based on the mapped 166,700-neuron MaleCNS connectome of an adult male Drosophila central nervous system.

humanvsbrain.com
Article

Is the fruit-fly CNS actually trading?

The internet says a fruit-fly brain is now: • playing DOOM • trading crypto • flying drones The experiments are real. But “a fly brain did X” leaves out a LOT. Here’s what is actually happening🧵

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what do you mean bumble for fruit flies?
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Doom ✅ Mario ✅ Crypto trading ✅ WIRED story ideas ✅ The MaleCNS fruit-fly connectome keeps getting new jobs. Mine has one: beat you. Human vs Brain 166,700 neurons. 10 rounds. No signup. humanvsbrain.com
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Humans have 86 billion neurons. A fruit fly has a tiny fraction of that. Seems unfair. For the fly. Until it beats your reaction time. 🧠 Human vs Brain
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Scientists mapped 166,700 neurons in the nervous system of an adult male fruit fly. We're turning that connectome into an opponent. Cooking. Human vs Brain.
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