I don’t want to grow old with type 1 diabetes, so we’re starting now to work on a cure.
For ten years, Marie and I have dreamed about working on this. But we couldn’t see what we could uniquely bring to the problem.
Now we can.
Recent breakthroughs in AI-driven mathematics were the final push, including yesterday’s announcement of a solution to the Navier–Stokes problem. Seeing AI tackle long-standing mathematical problems has made us more hopeful about what we could contribute to research on gene and cell therapies.
We know how to build systems of AI agents that work in parallel, test ideas, ditch what doesn’t work, double down on what does, and keep going.
We’ve had hundreds of agents working on questions around producing beta cells, keeping them alive, and protecting them from the immune system. We’ve published the work so far.
The holy grail is a "world biology model" of type 1 diabetes that we can experiment on virtually. Once that model is reliable, we could run thousands of experiments in parallel and take the most promising ideas into the lab. We’d still need biological validation, but we could learn much faster than the timelines of mice and wet labs currently allow.
We might be five years away from that, or we might be months away. I don't now yet. But we’ll be there!