Molecular and Cellular Proteomics (MCP) | Research, perspective, technological innovation and resources, and issues in proteomics articles | Published by @ASBMB
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Learn about JBC, MCP & JLR reviewers whose exceptional dedication is reflected in the quality, timeliness and consistency of their reviews: asbmb.org/asbmb-today/people….
New in MCP press| A temporal phospho-acetylome atlas of human myogenesis identifies coordinated post-translational regulation.
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ALT Figure 1. Workflow, sample overview, and global identification statistics.
New in MCP press| Proteome-wide ubiquitinome profiling reveals substrate-specific dynamics within the USP7 network.
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ALT Fig. 6. USP7 connects various neurodevelopmental syndromes.
Our latest study @molcellprot uncovers a hidden crosslinking chemistry of lipid peroxidation! We show that an endogenous aldehyde crosslinks vicinal cysteine–lysine pairs in cellular proteins via Michael addition and Paal-Knorr condensation. #LipidPeroxidation#Crosslinking
🧠 Via @MolCellProt:
Researchers at @WinshipAtEmory have developed a new proximity-labeling method to identify the proteins that interact with tau during aggregation, uncovering hundreds of tau-associated proteins linked to neurodegenerative disease.
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New in MCP press| N-glycosylation of AXL receptor tyrosine kinase regulates its stability, phosphorylation and oncogenic function.
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ALT Figure 4 | Spectra of identified glycosylated peptides Representative spectra showing glycopeptide and glycan fragmentation patterns of AXL glycosylation sites N43 (A), N157 (B), N198 (C) and N345 (D).
New in MCP Press| Scientists present MsTargetPeaker, a quality-aware search procedure for identifying peak regions in targeted proteomics data.
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ALT Figure 7 .Usage workflow of MsTargetPeaker and diagnostic reports.
🌍 Join #MolCellProt in celebrating the International Day of Women and Girls in Science!
Women in Proteomics, a new MCP special issue, showcases women driving innovation and discovery in proteome research.
➡️ Read more: mcponline.org/women-in-prote…
🎨 Luciana Giono
ALT Cover of Molecular & Cellular Proteomics special issue featuring portraits of women scientists in proteomics against a colorful gradient background.
This special issue of Molecular and Cellular Proteomics spotlights the leadership and achievements of women in proteomics, celebrating their scientific excellence, innovation, and transformative impact on the field.
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New in MCP Press| Circulating extracellular vesicle protein biomarkers for the early detection of high-grade serous ovarian cancer.
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ALT Figure 7. Development of a combinatorial exo-protein diagnostic biomarker panel and assessment of MUC1 exo-protein in plasma-derived EVs.
#WorldCancerDay research spotlight: "High accuracy stool biomarkers of pre-cancerous colorectal cancer identified using a 2000-plex immunoproteomic screen" by Vanarsa, Kamala et al.
➡️Access the #MolCellProt paper: mcponline.org/article/S1535-…
ALT Antibody array-based proteomic screening of colorectal cancer stool and graphical representation of significantly different proteins in CRC vs HC.
#WorldCancerDay | Researchers analyze protein and RNA data across 13 cancer types to find similarities that could improve cancer staging, prognosis and treatment strategies.
➡️ Read about this recent article published in Molecular & Cellular Proteomics: asbmb.org/asbmb-today/scienc…
In this special issue of Molecular and Cellular Proteomics, we wish to recognize and celebrate the career achievements of Professor Donald Frederick Hunt upon his retirement after 60 years in science.
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New in MCP press| Scientists observe that proteins selected based on their measurement robustness are still able to capture differences in abundance across disease groups in a small sample set.
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ALT Figure 2. CSF survey PRM assays developed from either Stellar MS linear ion trap (LIT) GPF library or Orbitrap™ (OT) GPF library data.
New in MCP press| plasma Proteome-Driven Liquid Biopsy for Individualized Monitoring and Risk Stratification of Immune-Related Adverse Events in Checkpoint Immunotherapy
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ALT Figure 2. Differential protein abundance analysis of plasma samples across irAE groups.