'Bridging scales' from #smallmolecules to #cells. How can we combat the development of #humandiseases like #cancer? Max Planck Institute of Molecular Physiology
Dortmund, Deutschland
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We congratulate Luis Demuth, Phd student in the lab of Andrea Musacchio, on receiving the highly-coveted Boehringer Ingelheim Fonds (BIF) PhD Fellowship. BIF‘s fellowships have the reputation of being a certificate of excellence.
➡️ mpi-dortmund.mpg.de/news/lui…
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Take a look at this recently published paper in LSA:
Proliferation and differentiation in intestinal organoids are balanced by ligand-modulated EGFR trafficking
@mpimoph
hubs.la/Q04vF1-_0
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Our group leader Andrija Sente has received the highly coveted @ERC_Research Starting Grant. His group will explore the molecular mechanisms and cell biological pathways that control the biogenesis of several classes of neurotransmitter receptors.
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Medium ligand-composition and concentration modulates EGFR signaling competency at the plasma membrane, balancing crypt proliferation and villus differentiation, enhancing mouse intestinal organoids self-renewal.
@mpimoph
hubs.la/Q04vDq760
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After successfully completing her biological laboratory technician training, Franziska Müller went on to earn first a bachelor’s and then a master’s degree - all while working as a technical assistant. Kudos!
We wish Franzi every success as a doctoral candidate at @LMU_Muenchen
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Congrats to Verena Cmentowski, former PhD student in the Musacchio lab, on receiving the @maxplanckpress Otto Hahn Medal "I am deeply grateful to my supervisor, Andrea Musacchio, for his guidance and ongoing support, which have helped shape me into the researcher I am today."
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NRAS mRNA-Degrading Bifunctional Small Molecules Induce Diverse Cellular Morphological Changes in #CancerCells
Published by the Peng Wu Group in @JACS_Au
pubs.acs.org/doi/10.1021/jac…
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The Gersch Group developed a well characterized matched chemical pair of inhibitor and degrader for the investigation of the #DUB #USP7 in #solidcancers together with the Cancer Center at the @UniklinikEssen Congrats to @NikolasKlink et al.!
nature.com/articles/s41467-0…
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Ancient co-option of LTR retrotransposons as yeast centromeres - New publication by the labs of Andrea Musacchio @maxplanckpress & Jef Boeke @nyuniversity published in @Nature - congrats to Max Haase et al.
nature.com/articles/s41586-0…
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Two new papers from the Musacchio lab published in The EMBO Journal!
link.springer.com/article/10… Kai Walstein, Louisa Hill & others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10… Arianna Esposito Verza and others – On mechanism of activation of PLK1
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We warmly welcome our new #LiseMeitner Group Leader Katerina Naydenova. Her group will investigate cellular defence mechanisms and develop novel methods in the field of cryogenic electron microscopy.
Learn more about Katerina and click on the link 🔗
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We warmly welcome our new independent @maxplanckpress Group Leader Andrija Sente. His group will investigate the molecular mechanisms of neuronal communication.
Learn more about Andrija and his work and click on the link🔗
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Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann, Slava Ziegler and Georg Winter @CeMM_News in @NatureChemistry
nature.com/articles/s41557-0…
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paper alert🚨
CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases - published by the groups of Tanja Bange @LMU_Muenchen & Andrea Musacchio in @NatureComms
nature.com/articles/s41467-0…
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Paper Alert 🚨
Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders - published in @angew_chem by the Waldmann group
onlinelibrary.wiley.com/doi/…
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MPI Dortmund retweeted
Pseudo-Natural Products Inspired by Aspidospermidine-, Strychnos-, and Koumine Monoterpene Indole Alkaloids Reveal Pyrimidine Biosynthesis Inhibitors (Herbert Waldmann and co-workers) • onlinelibrary.wiley.com/doi/…
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Pseudo-Natural Products Inspired by Aspidospermidine-,Strychnos-, and Koumine Monoterpene Indole AlkaloidsReveal Pyrimidine Biosynthesis Inhibitors - published by Waldmann lab in @HelvChimActa dedicated to Armido Studer @uni_muenster
onlinelibrary.wiley.com/doi/…
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Researchers led by Stefan Raunser have redefined the function & role of key factors in actin filament disassembly. "We uncovered a dance between proteins - a molecular choreography.” Congrats to @WoutOosterheert et al. @CellPressNews
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"My time at the MPI Dortmund has been amazing! Not only have I made many friends, but I've also gained the required skills that laid the foundation for the next step in my career. " Congrats to @WoutOosterheert
on his new group leader position at the the @NKI_nl 👏
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Using 16 (!) cryo-EM structures, the @Intein laboratory uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments. Congrats to @WoutOosterheert et al.
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