Pharmacology needs more than a detectable response. It needs data you can trust and scale. When working with complex neuronal models, robust and reproducible functional readouts are essential to confidently distinguish compound effects from biological variability. In this study using @InSphero 3D InSight™ Human Neural Microtissues, high-density electrophysiology revealed: 🔹 Consistent functional activity across independent samples 🔹 Robust, high-amplitude action potentials captured across different time scales 🔹 Distinct electrophysiological responses to kainic acid, 4-AP, isoguvacine, and TTX Together, these results show how HD-MEA recordings can combine reproducibility with the sensitivity needed to characterize compound-specific effects in complex 3D neuronal models. With multi-well formats and automation-ready workflows, MaxTwo extends this approach to studies ranging from pharmacological validation and compound-response profiling to longitudinal and chronic compound testing. Data obtained in collaboration with @InSphero. 👉 Explore these data and more pharmacology & toxicology case studies: mxwbio.com/applications/phar… #Pharmacology #Toxicology #DrugDiscovery #Spheroids #Neuroscience #HDMEA