Radically extending human healthspan
South San Francisco, CA
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Following breakthrough results, we’re bringing longevity medicine to human trials.
We’ve raised a $435M Series C led by @foundersfund to make it happen.
Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.
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NewLimit retweeted
.@newlimit is hosting a dinner in boston on sept 24 to connect with talented scientists & engineers
we promise an evening of surprising conversations, good food, & better company
let us know if you or a friend are interested in joining!
newlimit.notion.site/3cf10a8…
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NewLimit CEO @jacobkimmel explains the clinical trial bottleneck AI can't fix: biology has irreducible latency
"It's unlikely we're gonna see rapid expedition of clinical trials because a lot of the periods of time can't be expedited based on the biological primitives. In computer science you often have a notion of bandwidth and latency."
"There are some irreducible latencies in clinical trials. If you wanna give a drug to a patient and see if they're healthy a month later, it's not like you can enroll 30 patients and check back in one day. You just need to wait a full month. The classic nine people can't have a baby in one month story."
"The other thing we can hope for is that the success rate might improve. Right now, rough math, roughly 9 out of 10 drugs that go into the clinic will ultimately fail."
"If you're able to even just 2X that success rate, getting to 20% success rather than 10%, then you would double the number of drugs that come out every year, and you would cut the effective cost in half."
@newlimit
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NewLimit retweeted
.@newlimit CEO @jacobkimmel on why AI is biotech's biggest shift in 40+ years:
"I really do think artificial intelligence in biopharma is the first revolution we've seen since recombinant DNA of the same scale.
It's the first technology disruption on the same order of magnitude.
And I think what we're going to see is some of these firms that are developing models that help us design molecules, partner with pharmas to develop those molecules and make medicines that just couldn't have existed before."
— Jacob Kimmel, Co-Founder and CEO of NewLimit, on @corememory
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NewLimit retweeted
The two best longevity drugs on the market currently are exercise and sleep. And they're free!
If @newlimit is successful, we might surpass those.
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NewLimit retweeted
first-in-history data arrived @newlimit today
small piece of a note to our team. we are so lucky to be living in this future.
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NewLimit retweeted
enjoyed chatting with @SabrinaHalper in the lab (!) a few weeks back
rarely do i get to cover whale lifespans, @newlimit, spacefaring human speciation events, & ai therapeutic design in one place
"Aging is the process of a complex system slowly falling into its chaotic disequilibrium. And it's not like evolution necessarily even set a lifespan for us. It is merely the result of, once the system has been established, how long its intrinsic property stayed ordered before it became disordered."
I’m excited to share my conversation with @jacobkimmel of @newlimit.
Every species who has ever lived has one shared certainty: we’ll age, decay, and die. Jacob and his team are among the small group of people on earth with the expertise and funding to work on this problem.
We talked about why we age, whether cellular aging can actually be reversed, how evolution shaped our lifespan and our peaks, and how AI is fundamentally changing the next era of science.
Recorded at New Limit’s HQ in South San Francisco.
Timestamps:
00:00 Intro
01:25 Why Evolution Limits Lifespan
03:13 Evolution Tradeoffs Explained
07:44 Why Women Live Longer
10:15 Lessons from Long Lived Species
16:20 Peak Intelligence
23:26 What is Aging?
27:59 Yamanaka Factors
32:18 New Limit
33:56 AI's Role in Progress
37:28 Organ by Organ Longevity
40:28 Is Immortality Possible?
42:04 Lifespan Progress
45:44 How to Test Longevity Drugs
49:30 Placebo Mind Body Link
53:56 What longevity hacks actually work?
57:25 Peptides And Stem Cells
01:00:34 Gene Editing
01:05:10 Personalized Medicine
01:08:48 Philosophical Dilemmas of Longer Lifespans
01:14:57 Living Off Earth
01:16:55 AI And Bio Risks
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NewLimit retweeted
this is our most dynamic summer yet @newlimit
- 3X data efficiency for reprogramming AI from lineage generalization
- >100X manufacturing scale for our lead therapeutic asset
- +4 leads that restore function in old hepatocytes, +5 payloads in endothelium
& lots more in our blog
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NewLimit retweeted
NewLimit made major progress in the past year toward our mission of radically extending human healthspan.
Check out this talk where we run through what we've built, and our vision for where it's going.
every year @newlimit, we host friends at the lab & share our progress
for 2026, we announced:
- 2X increase in discovery rates with AI systems
- new program for endothelial cells
- 0 -> 1 medicines headed to the clinic
- accelerating recovery from alcohol
some highlights --
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NewLimit retweeted
every year @newlimit, we host friends at the lab & share our progress
for 2026, we announced:
- 2X increase in discovery rates with AI systems
- new program for endothelial cells
- 0 -> 1 medicines headed to the clinic
- accelerating recovery from alcohol
some highlights --
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NewLimit retweeted
in our 2026 @newlimit progress update, we announced our first candidate medicine.
it has the one of the most striking effects i’ve ever seen.
a single treatment accelerates recovery from alcohol in old animals. it’s so dramatic you can see it with your bare eyes!
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Each year, we share a public update on our progress @newlimit from our lab in South San Francisco.
This year, we announced:
1. 2X increase in discovery rates with AI systems
2. New program focused on endothelial cells
3. 0 -> 1 medicines headed to the clinic
Full event video below
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NewLimit retweeted
Imagine you had the energy, metabolism, and mental agility of your younger self - without the aches and pains that come from aging.
That’s what we’re attempting to build at @NewLimit and it will be one of the most important achievements in human history ever if it works.
We're on the cusp of this being tractable given the rise of AI to test more hypotheses in-silico, along with the rapidly falling cost of single cell sequencing, etc.
We announced our Series C and upcoming human clinical trials this week, so still a long, long way to go, with many risks. But with hard work we've got a shot at making this a reality.
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NewLimit retweeted
New Limit just raised $435 million. This is, in part, because they've had a massive breakthrough on reversing the age of the liver with their new brand of genetic reprogramming drugs.
For the first time, NewLimit's co-founder and president Jacob Kimmel details the company's breakthrough here.
We also get into the longevity and bio-tech fields more broadly to explain where aging science and AI are heading.
If nothing else, come to see some mice get drunk.
The Core Memory podcast is available wherever you pod, and I'll put the YouTube link down below in the replies.
Our show is sponsored by Brex and SendCutSend. They are both wise and benevolent.
Timestamps
0:00 Intro
3:50 What Is Epigenetic Reprogramming?
7:16 Growing a Whole Animal From One Old Cell
13:06 Meet Ambrosia, the AI Hunting for Youth
22:44 $435 Million and the Race to Human Trials
29:26 The Drunk Mice That Skip the Hangover
36:48 Inside the First Human Trial
43:14 Will There Ever Be a Hangover Pen?
49:39 Beyond the Liver: The Delivery Problem
1:03:27 Answering the Skeptics
1:12:42 Will OpenAI Become a Drug Company?
1:23:53 The Health Story Bigger Than AI?
1:35:00 How Far Behind Is the US vs China?
1:53:10 Can We Build Computers From Neurons?
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NewLimit retweeted
Your reminder that we have a glorious video taking a look inside @newlimit's labs. piped.video/watch?v=GSOSuROe…
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NewLimit retweeted
NewLimit, the anti-aging startup co-founded by Coinbase CEO Brian Armstrong, has closed the 2nd largest round in biotech for 2026: endpoints.news/anti-aging-bi…
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NewLimit retweeted
Human trials next year for @newlimit's first aging reprogramming medicine with an exciting pipeline behind it. An honor to be a partner to @jacobkimmel @byersblake @brian_armstrong and NewLimit's stellar scientists
The aging research will continue. Thank you @foundersfund for leading, @ThriveCapital, @Greenoaks and @QuietCapital for joining and all our insiders for coming back.
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NewLimit retweeted
The aging research will continue. Thank you @foundersfund for leading, @ThriveCapital, @Greenoaks and @QuietCapital for joining and all our insiders for coming back.
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NewLimit retweeted
The aging research will continue. Thank you @foundersfund for leading, @ThriveCapital, @Greenoaks and @QuietCapital for joining and all our insiders for coming back.
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NewLimit retweeted
Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born.
NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline).
Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.
Following breakthrough results, we’re bringing longevity medicine to human trials.
We’ve raised a $435M Series C led by @foundersfund to make it happen.
Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.
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NewLimit retweeted
on day 1 @newlimit, we imagined it would take 10+ years to invent real medicines.
our recent results have accelerated the timeline to next year. we've raised a Series C led by @foundersfund alongside @ThriveCapital, @Greenoaks, and many others to bring therapies to the clinic.
medicines for aging are among the most valuable possible technologies. we are grateful to our partners for the opportunity to pursue this mission.
Following breakthrough results, we’re bringing longevity medicine to human trials.
We’ve raised a $435M Series C led by @foundersfund to make it happen.
Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.
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