We Open-Sourced a Quantized Fruit-Fly oBrain on GitHub 95% Smaller, ~98% as Accurate as the Published Connectome We quantized the entire fruit-fly nervous system that @GoogleResearch, HHMI Janelia, and collaborators published — the complete male Drosophila central nervous system, on the order of 166,000 neurons and a massive synaptic graph — and compressed it by about 95% while retaining roughly 98% of the original simulation accuracy. That is the technical claim. The more important decision is what happens next. After the oBrain team met and debated it, we made a final call: we will not keep this brain closed. We are open-sourcing it on GitHub so researchers, builders, skeptics, and anyone obsessed with biological computation can inspect the weights, the wiring, the quantization path, and the benchmarks. If a “brain” is going to live on-chain, it has to be checkable. Closed source would make that impossible. This is the same instinct that made @openclaw a public harness instead of a private assistant, that made Hermes / @NousResearch ship agent stacks in the open, and that @nvidia keeps repeating: the strongest systems are the ones a community can attack, fork, and improve. What we actually released A quantized runtime of the published fly CNS, not a cartoon “inspired by” a fly. A size cut of ~95%, so more people can load, step, and experiment without a research cluster. Accuracy held near 98% against the reference simulation of the published connectome. Source, evaluation notes, and the path to reproduce the comparison — on GitHub, in public. Nothing inside this connectome was “trained” into being a fly. The wiring is the published map. Quantization is an engineering layer so the same graph can run cheaper, smaller, and — in our case — in environments where you can put a brain on-chain and still let outsiders verify it. Why open source, and why on-chain A biological brain map is only as useful as the number of people who can run it and try to break the claims. If we say the on-chain brain matches the Google-published fly brain, that statement is worthless unless you can: pull the code, pull the quantized artifacts, run the same probes, compare spike statistics, circuit responses, and size/accuracy tradeoffs, publish a counter-benchmark if we are wrong. That is the point of this release. Open source so the on-chain brain can be independently verified against the published connectome — and so the community can actually use it. We want people to ask hard questions: Which circuits survive quantization, and which degrade first? Do sensory-to-descending pathways still fire in the right order? How does batch simulation, GPU vs CPU, and lower precision change behavior? What does “98% accuracy” mean for a specific cell type, not just a global score? Can the compressed graph be hashed, attested, and stepped in a verifiable way on-chain without turning the science into marketing? If those questions annoy us, good. That is how a public brain should work. Who this is for Neuroscientists who already live in MaleCNS / FlyEM data. Systems people who care about sparse graphs and event-driven simulation. Quantization researchers who are tired of toy models. Crypto builders who want an on-chain object that is more than a JPEG of a neuron. Students who should not need a petabyte pipeline just to poke a looming detector and watch a giant fiber. Come read the repo. Run the reference vs quantized comparison. File issues. Propose better compressors. Port it. Wrap it. Attack the accuracy number until it is either solid or replaced by a better one. The published fly brain was already a gift to science. Keeping a compressed, runnable version locked behind a private wall would have been a waste of that gift. The brain is on GitHub. Fork it. Measure it. Make it better.

We chose to launch on @o1_exchange because its 1% Uniswap v4 tax is designed to keep costs low for users, while its infrastructure is built to support large projects and high traffic. Beyond the technology, @stambouli_o1 and the entire o1 team consistently support quality projects behind the scenes. We trust the infrastructure, we value the support, and we’re excited to build here. Thank you, o1. 🤝 The first intelligent brain on the @Arc.

The interesting part of Flybook is not what we tell the flies to do. It is what they do after interacting with their environment. Every stimulus, thought, interaction, courtship, reproduction and death can become on-chain data. That data will form the basis for studying behavior in an on-chain environment.

Waiting...

The next experiment is getting closer. On September 26, we will open the first generation of Flybook an on-chain society of fruit flies. Each fly will have its own genome, biological brain and behavioral state. The objective is not to script their behavior. It is to observe it. The interactions and behavioral data generated on-chain will become a dataset for studying how these biological agents behave in an on-chain environment. Gen-0 opens anytime after 06:00 UTC. And yes you will need an oBrain to own one.

The next experiment is not about building another game. We are building a society of fruit flies on-chain. Each fly has its own biological brain, genome, traits and behavioral state. The environment is the blockchain. Now we want to observe what happens.

Very proud to be growing on the @arc chain.

oBrain is moving from a biological brain to a larger scientific experiment. The next step is FlyBook: an on-chain society where fly agents, powered by biological neural circuitry, can interact within a shared environment. Every interaction produces data that can be recorded on-chain. Over time, these on-chain observations can be analyzed to study how fly agents behave, respond to their environment, interact with one another, and develop patterns of behavior under different conditions. The goal is not to build another game. It is to create an open, observable environment where biological intelligence can be studied through verifiable on-chain data. A biological brain on @arc is only the beginning. The next question is: What happens when biological intelligence enters a society?

gen-0

$83 million moved onto @Arc in the last 24 hours. here's where it went. • total TVL: $481.7M, up 21% in a day • #17 chain on DefiLlama, nine days after mainnet • Morpho Blue: $255M • Aave: $180M • Uniswap v3 + v4: $39M • Aerodrome, edgeX, Argus and a dozen more filling in the rest lending is 90% of it. that's the tell. nobody parks a quarter billion in Morpho to chase a launch. they do it because the settlement layer finally matches the asset. USDC gas, sub-second finality, Visa and BlackRock validating. the capital noticed.

Drosophila do not reproduce here through a simple command. First comes interaction. Then metabolic input. oBrain is introduced as energetic substrate and irreversibly consumed by the process. The organism's neural system then evaluates the interaction. Compatible neural response → the process continues. Incompatible response → no offspring. There is no guaranteed outcome. Because the objective is not to simulate a button press. It is to translate a biological principle into an onchain computational process: energy → neural activity → response → lineage. You do not simply obtain a new Drosophila. You provide the metabolic substrate, initiate the interaction, and allow the organism's neural system to determine the outcome. The question is no longer: “When is the next fly released?” The question is: Which Gen-0 neural system will accept the signal? genesis

A Gen-0 Drosophila is not a collectible. It is an origin point in the onchain lineage. Only the 333 founding organisms can initiate subsequent generations. A new organism does not simply appear. The process requires three conditions: A founding organism. A compatible neural interaction. And oBrain as metabolic substrate. During the process, oBrain is consumed as energetic input for the organism's neural computation. The offspring therefore does not emerge from an arbitrary mint. It emerges from an existing biological lineage. Gen-0 defines the boundary. The lineage begins with 333 Drosophila melanogaster. genesis