Out latest preprint describes a plasmid lineage we've been tracking in Birmingham's QE Hospital - short 🧵👇
biorxiv.org/content/10.1101/…
@alanmcn1
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pQEB1 carries the KPC-2 carbapenemase gene, and has been found in multiple bacterial hosts - genera, species and STs
Its precise structure is unique and has yet to be seen outside England's West Midlands
Jun 14, 2024 · 2:51 PM UTC
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It's been evolving in the hospital through the actions of smaller MGEs
We've seen IS26-mediated inversions and acquisitions of various IS/transposons, including carriers of heavy metal resistance genes
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