🔬 Join the WPC 2029 Science Ambassador team! Apply by Nov. 5! #WPC2029 worldpdcoalition.org/2029Sci… #WPC2029 #scienceambassador #parkinsonsresearchh #parkinsons #mywpcstory

I recently presented preliminary trial results in the Clinical Breakthrough session at the MDS meeting in Seoul (2026). Watch a presentation of these results here: profsimonlewis.com/mds-clini… And the media response here: profsimonlewis.com/tv-irbd-t…

The Braak Paradox: When Parkinson’s pathology and clinical progression disconnect. For more than two decades, the Braak hypothesis has shaped how we think about Parkinson’s disease, suggesting that abnormal alpha-synuclein pathology spreads through the brain in a predictable sequence as the disease advances. What resonates with me about this new study by di Biase and colleagues, and the accompanying thoughtful editorial by Rodríguez-Violante in Neurology, is that the biology may be far more complicated than the model. In 61 people with autopsy-confirmed Parkinson’s disease, Braak stage did not correlate with motor disability, disease duration, age at death, or brain weight. In other words, having more widespread alpha-synuclein pathology did not necessarily mean having more advanced clinical disease. The editorial importantly reminds us that this finding does not invalidate Braak staging or the importance of alpha-synuclein, but rather exposes the limitations of using pathology as a clock for clinical progression. Parkinson’s is not one disease following one predictable path, and the frequent presence of other pathologies, including tau, amyloid, and vascular disease, further complicates the picture. For me, the lesson is that we must be careful not to confuse what we see under the microscope with what patients actually experience. As we develop biological staging systems, biomarkers, and disease-modifying therapies, we need to measure not only abnormal proteins but also neuronal loss, clinical disability, and the individual trajectories of people living with Parkinson’s. The patient, not the pathology, must remain at the center of our science. neurology.org/doi/10.1212/WN…

Join Caroline M. Tanner at the next Research Spotlight for a look at #Parkinsons prevention and precision medicine. 📅 October 13, 2026 | 🕚 11 AM ET / 4 PM UK Learn more & register: worldpdcoalition.org/WPCRese… #ParkinsonsResearch

💙 We’re thrilled to welcome @ParkinsonsBC as a new WPC Champion Partner! #WPC2029 #Parkinsons

🌎 WPC welcomes five new Board members bringing global expertise, lived experience & fresh perspectives to Parkinson’s advocacy. Read the full press release here: einpresswire.com/article/939… #WPC2029 #WorldParkinsonCoalition #Parkinsons

🥗🧠 Can what we eat influence Parkinson’s? Explore the gut-brain connection in our latest WPC Blog post by researcher Felipe Andrés Grunenwald Bravo, PhD. 🔗 Read the blog: worldpdcongress.org/home/202… Blog made with support from @Supernus_Pharma #Parkinsons #Research #WPCBlog

We’re thrilled to welcome Northwest Parkinson's Foundation as a WPC Champion Partner! 💙 #WPC2029 #WorldParkinsonCongress #Parkinsons

🌎 WPC 2026 Ambassadors brought passion, knowledge & community to Phoenix. Now, we’re growing the community in Québec City! 💙 Applications open Oct. 1! #WPC2029 #WorldParkinsonCongress

Help us to be part of the solution @Macquarie_Uni Brain Institute and Clinic: 7news.com.au/video/news/aust…

🧠🌎 Stay informed. Stay connected. Subscribe to the WPC Blog for the latest from WPC. 👉 Visit worldpdcongress.org/contact to subscribe. #WPC #Parkinsons #ParkinsonsResearch #ParkinsonsCommunity #blog

🎥 From the Frontlines: WPC 2026! Laura Langer speaks with Tony Wilkinson about Parkinson Voice Project. Watch: youtu.be/F3kWx-fxinw #WPC2026 #Parkinsons

Movement was everywhere at #WPC2026! 💪 Exercise and wellness were a major focus, celebrating the many ways to stay active and live well with Parkinson’s. 💜 #Parkinsons #ExerciseAndPD

Parkinson’s is a family disease. Join our FREE Family & Care Partner webinars Nov. 16–20. Register now: worldpdcoalition.org/2026car… #Parkinsons #CarePartner

Professor Simon Lewis tackles the “fake news” that surrounds Parkinson’s disease and warns viewers to be alert to common myths, hype and misleading claims online: profsimonlewis.com/fake-news…

Good to see orthostatic tremor covered in the Australian media - a rare neurological disease that can cause severe imbalance and trouble standing. nine.com.au/australia-news/a…

Initial results from the @SyntaraTx & @ParkinsonsUK Phase 2 study of SNT-4728 (dual SSAO/MAO-B inhibitor) in REM sleep behaviour disorder look encouraging; Satistically significant⬇️in brain inflam. observed unilaterally in the putamen (p-value 0.0145) parkinsons.org.uk/news/2026/…

Big challenge in Parkinson’s is that synuclein seeding assays can be positive across many diseases. Nice plenary this morning showing how this group uses synuclein seeding + 4 R TAU + NFL to sort this out using a multi-modal biomarkers approach. This is one such approach used at the University of Toronto and presented today at the World Parkinson Congress.

The World Parkinson Congress has officially kicked off in Phoenix, and there is a rumor circulating that more than 1,000 free copies of book The Parkinson’s Plan may appear Monday at the Parkinson’s Foundation booth. Ray Dorsey and I will be at the WPC Book Nook from 12–1 PM (on Monday) meeting folks and signing books. I will also be at the Parkinson’s Foundation booth from 11 AM–12 PM and again from 1–2 PM (on Monday). Come by, say hello, and most importantly "Tell your story." You are the secret sauce to creating change. #WPC2026 #WorldParkinsonCongress #Parkinsons #ParkinsonsDisease #ParkinsonsAwareness @ParkinsonDotOrg

Disappointing news but we owe it to the community to keep working harder to find a cure!