Huberman's routine bloodwork showed his blood lipids were out of range.
He decided to start supplementing NATTOKINASE, and in a follow-up test, his blood lipids were back to normal.
Is NK the best supplement for heart health?
Let's look at the evidence: (1/16)
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In one of the biggest NK studies, researchers tracked 1,062 people with confirmed hyperlipidemia and carotid artery plaque.
These weren't just healthy volunteers.
Every person had an ultrasound at the start and another after 12 months of daily nattokinase.
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The study used two dose groups: 3,600 FU and 10,800 FU per day.
The low-dose group saw almost no change in their plaque or lipid markers.
Even though it was the same supplement for the same amount of time, the dose made the difference.
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At the highest dose, carotid artery plaque and arterial wall thickness shrank significantly.
These are physical, structural changes that doctors measured and confirmed on ultrasound.
Joe Rogan discussed the exact numbers on his podcast:
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77.7% of participants showed measurable improvement in arterial wall thickness.
66.5% showed measurable reduction in plaque size.
Improvement rates across all markers ranged from 66.5% to 95.4% for the majority of over 1,000 people, not some few lucky responders.
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The participants lipid results moved in every right direction simultaneously.
- Total cholesterol: down
- LDL: down
- Triglycerides: down
- HDL: up
No adverse effects were recorded at any point across the full 12 months.
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Lifestyle also amplified everything.
Participants walking more than 5,000 steps daily responded better than sedentary ones, and those with higher BMI saw larger relative improvements, likely because they started from a higher risk baseline where there was more room to move.
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The study also tested co-administration.
Vitamin K2 and low-dose aspirin taken alongside nattokinase produced a synergistic effect, outperforming nattokinase alone across cardiovascular markers.
If you're building a stack, that's the combination the data points to.
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On top of this, a lab study found that NK was able to eliminate 84% of amyloid microclots that were recently found in 100% of the tested COVID-19 vaccinated individuals.
It was able to break down both the trigger (spike protein) and the pathological result (amyloid microclots).
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To see why this matters, look at the "steel web" problem.
In long COVID, blood protein turns into an "amyloid" form.
Normal clots are like loose spider webs, but these are like webs made of steel cable. Your natural enzymes can't break them down.
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Scientists tested nattokinase against these lab-grown "steel" clots.
At a concentration of 28 ng/µL, the number of clots dropped by half in two hours. By the six-hour mark, the total amount of amyloid was mostly gone.
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Why does nattokinase work when our own body fails?
Our natural enzyme, plasmin, struggles with amyloid structures.
Nattokinase is also a serine protease, but it can also degrade the amyloid form of fibrin that plasmin simply cannot break down.
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Does this mean you should go buy natto?
Researchers used a purified version because supplements vary in quality.
Since these enzymes are recognized as safe, they concluded that a large human trial is needed to prove this works in people, not just in a lab.
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If you want to try NK, Toku Health is a brand I like. They use the traditional Bacillus subtilis natto fermentation strain.
The researchers in this study used a purified lab version, and Toku is the closest real-world equivalent.
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I've talked to the CEO and they're doing it the right way, so I'll leave the affiliate link for you guys to save 20% if you want to try it out:
partners.tokuhealth.com/PATR…
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Jul 1, 2026 · 4:34 PM UTC
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