We are proud of staff like Darryl Taylor, who works at Froedtert Hospital in Environmental Services. Darryl went the extra mile in his workday, offering support and friendship to patient Lindsey Jacob and her family. tmj4.com/news/local-news/can…
We at @MedicalCollege are looking for energetic faculty looking to build a career in HCT & CART therapy with a focus on myeloid &/or plasma cell disorder. Home of @CIBMTR / @BMTCTN +
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Chilly yes but warm Friendly people. DM or meet at Tandem #bmtsm
In leukemias, are there any studies demonstrating benefit to post-HCT maintenance therapy in patients who enter transplant in an MRD negative state? Thanks @MediHumdani@sghmd@DrChrisHourigan
#ASH22. After single induction (7+3), for residual disease, lower intensity re-induction (Ven/HMA) was feasible and comparable to another cycle of 7+3, leading to less time in the hospital, NF and transfusions. MCW experience, but now a widespread practice.
Have a pt with Int Risk AML, got 7+3 and D+15&20 marrow 13% blasts. Discussed MA HCT, put him on a low intensity trtmt (HMA/Ven), said we’ll do HCT ASAP. This was 3 wks ago, have a Peer to Peer on Friday to seek HLA typing relatives…
CONGRESS | #ASH22
Sameem Abedin @sameem_abedin, @MedicalCollege shows 53% 1 year OS and 32% at 2 years with salvage lintuzumab-Ac225 (actimab-A) plus CLAG-M in phase 1 trial in patients with R/R AML, with 64% progressing to allo-HSCT.
#leusm#medicalcongress
Responses: 52% achieved a CRc. At our RP2D, 67% achieved CRc. CRc patients mostly (72%) were MRD negative by MFC. Most patients had at least 1 year of follow up, and we observed a median OS of 1 year, and estimated 2-year survival of 32%. 9/
In summary - safe to give LintuzumabAc225 at low doses with intensive chemo. Counts come back.
Given study population, LintuzumabAc225 appears to add in eliminating disease; would not have expected as high or as long of a response with salvage in this population.