Stem Pharm, Inc.@stempharm

Redefining neurological drug discovery with neuroimmune organoids Check out our latest paper: mdpi.com/2073-4409/15/14/126…

 Madison, WI
stempharm.com
Joined November 2016
16 Photos and videos
We’re excited to announce a $2.5M NIH Phase II SBIR award to advance our Alzheimer’s drug discovery program using our human neuroimmune organoid platform to identify and advance therapeutics targeting neuroinflammation. Read more: tinyurl.com/2weczz9e #Alzheimers #organoid
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New publication from Stem Pharm: Neuroimmune Organoid Models Early Glioblastoma Establishment and the Invasive Niche. Our human neuroimmune organoids reveal how GBM cells interact with microglia and macrophages during early tumor establishment. mdpi.com/2674-1172/5/3/23

Neuroimmune Organoid Models Early Glioblastoma Establishment and the Invasive Niche

Glioblastoma (GBM) is a highly aggressive malignant brain tumor accounting for 15% of all brain tumors and 50% of all gliomas. The exact cause of GBM is not fully understood but risk factors include...

mdpi.com
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By recreating early GBM invasion and tumor–immune interactions in a reproducible human model, Stem Pharm’s neuroimmune organoids could support: 💊 Invasion-focused drug screens 🧬 Patient-relevant studies 🔬 Immuno-oncology research 🎯 Personalized therapeutic strategies
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Microglia mounted a strong interferon response, consistent with an early anti-tumor immune reaction. But added macrophages increased signals associated with immunosuppression and tumor stemness, including IL-10 and PDGF-AA. The immune context matters.
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GBM cells do not maintain a single identity. In our neuroimmune organoids, tumor cells predominantly adopted an oligodendrocyte progenitor cell-like state. Adding macrophages further increased this invasive and proliferative phenotype.
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Our GBM model combines patient-derived tumor cells with human neuroimmune organoids containing: 🧠 Neurons 🔬 Astrocytes 🦠 Microglia 🩸 Vascular-like cells Macrophages can also be incorporated to investigate how peripheral immune cells reshape the tumor microenvironment.
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Why is glioblastoma so difficult to eliminate? GBM cells diffusely infiltrate surrounding brain tissue and can shift between cellular states, helping tumors evade treatment and ultimately recur. Our organoid enables study of this invasive niche in a human multicellular context.
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Stem Pharm, Inc. retweeted
Stem Pharm, Inc.@stempharm
Aug 4
Exciting to see Dr. Jeremy Kratz’s team selected for the WARF/MilliporeSigma Non-Animal Drug Testing Challenge - advancing cancer organoid testing with Stem Pharm’s synthetic SP-139 hydrogel combined with Kratz's use of patient-derived plasma. #Organoids #DrugDiscovery #NAMs
WARF (Wisconsin Alumni Research Foundation)@WARF_News
Aug 3
Congratulations to the @UWMadison teams selected for the WARF, @MilliporeSigma Challenge Grant! From organoids to organ-on-chip systems, AI-powered platforms and more, these projects are developing the next generation of drug testing technologies. warf.org/news/advancing-drug…
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🚨 New publication! 🚨 We're excited to share our latest paper in Cells: Stimulus-Based ApoE Alzheimer's Disease Induction Model Using Microglia-Containing Brain Organoids for Drug Discovery. 📄 mdpi.com/2073-4409/15/14/126… 🧵👇
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As the NIH and FDA continue advancing human-based New Approach Methodologies (#NAMs), we're excited to contribute models that better capture human biology and help accelerate development of new therapies for Alzheimer's disease. #Alzheimers #BrainOrganoids #Neuroinflammation
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Graphical abstract summarizing the paper
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New in J. Neuro-Oncology: our collaboration with @mahua_deyMD shows that our neuroimmune organoids can model diffuse midline glioma biology, capture patient tumor complexity, and enable cell-type-specific toxicity testing. link.springer.com/article/10… #NeuroOncology #DMG #Organoids

Human neural organoid modeling of diffuse midline glioma captures the complexity of patient tumors

Journal of Neuro-Oncology - Diffuse Midline Glioma H3K27-altered (DMG) is an extremely aggressive and lethal childhood brain cancer that grows within the midline structure of the brain. Current...

link.springer.com
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Madison is buzzing with investor events this week. 11/5–11/6: Wisconsin Early Stage Symposium (Monona Terrace) wisconsintechnologycouncil.c… 11/6: +Venture Health by NVNG (Element Labs) nvngia.com/venture/venture-h… We'll attend both. DM to meet. #MadisonWI #biotech #venturecapital
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Stem Pharm is heading to Neuroscience 2025 (San Diego, Nov 15–19). We are eager to connect on neuroimmunology across AD, other neurodegenerative disorders, epilepsy, and brain cancers. ▶️ Contact us to schedule a meeting. stempharm.com/contact #SfN25
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Big thanks to the Center for Technology Commercialization, Wisconsin Economic Development Corporation, & Wisconsin SBDC for the opportunity to share our work and connect with Wisconsin innovators. #SBIR #Innovation #Biotech
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🚨 New publication alert! 🚨 We’ve developed human neural organoids with microglia to model how environmental toxins cause neuroinflammation and developmental neurotoxicity (DNT). 📄 sciencedirect.com/science/ar…
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Bottom line: ✅ Human-relevant ✅ Mechanistic insight ✅ Scalable for screening This is a leap forward for DNT testing and neuroinflammation research. #NAMs #organoids #DNT #neurotox #neuroinflammation #toxicology #drugdiscovery #microglia #SBIR #NIH #FDA
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