@mghmedres intern | prev @harvardMITmdphd @broadinstitute @macosko lab
Cambridge
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Excellent work by @NadigAjay @Luke0connor !
How often is autism caused by de novo changes to the genome? What is the spectrum of penetrance across autism-associated genes? What can we expect from future autism gene discovery? I'm pleased to share a new preprint where we develop new statistical methods to answer these Qs.
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Tushar Kamath retweeted
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$.
With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…
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Tushar Kamath retweeted
2/8 Introducing Synapse-seq: our AAV-based tool for mapping brainwide presynaptic projections or postsynaptic distributions of molecularly-defined neurons, via protein-guided RNA barcoding & single-cell/spatial readouts: doi.org/10.64898/2026.02.26.…
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Tushar Kamath retweeted
We are thrilled to have the following superstars join our fellowship program in July 2026. Congratulations to Erik, Wes, Tushar, Brian, May and Shawna, and congratulations to the MGH GI Division for recruiting such talent. Welcome to the family!
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Tushar Kamath retweeted
The first piece of work from my PhD has now been uploaded to biorXiv! Short 🧵below:
Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Tushar Kamath retweeted
Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC
Led by the fantastic Hui Li, and co-supervised by @XihongLin
#ASHG24 poster 4089F
medrxiv.org/content/10.1101/…
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A particularly exciting way to look at transcriptional data using lessons learned from statistical genetics!
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
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Tushar Kamath retweeted
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
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Exciting stuff from @LaylaSiraj @julirsch and friends!
Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays!
biorxiv.org/content/10.1101/…
See below for a 🧵. 1/n
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What a fantastic presenter at SCGD!
Talk by @fluorocore on generalising single-cell analysis methods to spatial data #singlecellgenomicsday
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Thrilled to have matched at @MGHMedicine in the Stanbury PSTP! Thanks to all my mentors, family, and friends for the support and love.
Thank you to all the patients who have taught me so much so far and the ones that I will learn from on my next journey!
Doctorin’ soon! 🩺🫡
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Tushar Kamath retweeted
We now know the locations of cell types in a full mammalian brain.
Our work reveals the brainstem’s absolutely stunning cellular complexity. How and why does it arise?
Visit braincelldata.org to plot genes, localize types, and get markers.
nature.com/articles/s41586-0…
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Tushar Kamath retweeted
Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods:
1) Cell segmentation (the biggest problem)
2) robustness and scalability (well-powered case-control studies now possible)
3) Multiomics (ATAC, RNA, etc)
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags
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Tushar Kamath retweeted
Excited to share the next chapter of primate genomics in @Nature, where we (@illumina, @IBE_Barcelona, and @bcmhouston) created a multiple sequence alignment of 239 primate species to better understand non-coding regulatory elements!
nature.com/articles/s41586-0…
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Tushar Kamath retweeted
Excited to announce I will be starting my lab in @BIDMCpath @BIDMC_CancerCtr at @BIDMC . Using chemical genomic approaches and thorough biochemistry we will focus on revealing new mechanisms of metabolism regulated cell death with a special focus on metal (copper) biology.
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Excited to share the final version of our manuscript detailing our work in understanding some of the earliest cellular changes in AD from brain biopsies of living individuals: cell.com/cell/fulltext/S0092…
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A sentimental thanks to @macosko for all his support on what is likely the final contribution from my graduate thesis.
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I remember @macosko describing this project to me in my first week as a graduate student -- awestruck both then and now, I am immensely grateful to all those patients who contributed their brain tissue while still alive (!) to our efforts to understand Alzheimer's disease.
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