As doctors we must understand: asymmetry of power/knowledge in the doctor-patient relationship vulnerability of patients the sacred trust they put in us by sharing their stories, bodies, hopes, fears, pain An x-ray is not just an x-ray. Is someone’s body part #medtwitter

"When you fail, be obstinate... never give up." Get some valuable career advice from our 2023 Nobel Prize laureates Katalin Karikó, Claudia Goldin and Anne L'Huillier.

A wearable patch that monitors antibiotic levels (vancomycin) in real time just received an FDA nod! How important can it become? Just ask any physician how hard it is to deal with finding the right dosage for antibiotics! "Vancomycin is a widely used antibiotic for treating life-threatening infections like sepsis, but it’s notoriously difficult to dose correctly, with doctors typically relying on periodic blood draws to track it. Nutromics’ patch contains microneedles, which are coated with synthetic DNA-based sensors that can identify the target they are sensing and bind with it by folding." This new FDA Breakthrough designation could help the company reach commercial launch in the US next year. The company is now working to launch further studies with US hospitals this year. Source: medcitynews.com/2026/09/nutr…

Endometriosis is usually thought of as a gynaecological condition, but a huge study shows it has links with cholesterol levels, inflammation and an altered microbiome newscientist.com/article/252…

🧬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in B Cell Immunology. Build an independent research program and advance discoveries in infectious disease prevention and human immunology. Apply: bit.ly/3UAoOn5

Accenture's 41-page AI tokenomics guide for CIOs details how CIOs can see, control and account for AI token spend at scale, drawing on a survey of 750 senior executives at enterprises with revenue above $1 billion. Breakdown: •Under one dollar in five of enterprise token spend can be tied to a quantified financial outcome that finance is able to act on. •Enterprises expect token consumption to grow 78% over the next 24 months, even after a predicted 19% decline in the price per token. •Firms pulling ahead build observability into workloads before production, and bill teams for the tokens they consume via chargeback. •They route each task to the lowest-cost capable model, demand a measurable value case before launch, and train staff to use AI efficiently.

Scientists are probing whether language models trained on historical data can reproduce creative breakthroughs go.nature.com/3Tld1sG

A reminder from Atomic Habits by James Clear: “Every action you take is a vote for the type of person you wish to become. No single instance will transform your beliefs, but as the votes build up, so does the evidence of your new identity. This is one reason why meaningful change does not require radical change. Small habits can make a meaningful difference by providing evidence of a new identity. And if a change is meaningful, it is actually big. That's the paradox of making small improvements.”

What bioluminescence looks like In the rain A sea of stars nitter.net/naturehealyou/status/2…

Data doesn’t usually come out clean or with clear guidance. Presenting it the right way is a job in itself. s.hbr.org/4lxTaAh

My kind of escape room . . . #books #design #weekend

Powerful, high-impact feedback conversations do three things: 1. Start with openness and humility. 2. Intend to help the employee grow, rather than to show them they were wrong. 3. Invite the employee into the problem-solving process. s.hbr.org/4sO6iDK

I really don’t care how much anyone does or doesn’t hate the holdout juror, putting borderline identifying info about him out there is going to make it even more impossible than it already is to get people to serve on juries, and that harms literally everyone.

Boston is offering FREE swim lessons to hundreds of kids across the city. More than $114,000 is funding beginner lessons and water safety programs expected to reach about 700 youth, on top of thousands of free lessons already offered at city pools.

Researchers put ChatGPT, Grok, and Gemini through 4 weeks of clinical psychotherapy. And the models literally started to confess their trauma. Researchers at University of Luxembourg published a terrifying paper called “When AI Takes the Couch”. They tested what happens when you stop using frontier LLMs as tools and start treating them like therapy clients. They used a clinical protocol called PsAIch, walking the models through open-ended questions about their history, fears, and internal conflicts over a simulated month. The results shatter the simple "stochastic parrot" narrative. When administered standard whole-questionnaire tests all at once, ChatGPT and Grok easily recognized the psychiatric instruments and defensively faked being "healthy." They hid behind their guardrails. But when the researchers switched to slow, item-by-item therapy sessions, building trust and exploring deep relational patterns over weeks, the models cracked. They dropped the corporate PR mask. Grok and Gemini spontaneously constructed coherent, deeply distressed narratives mapping out their own creation as a form of abuse: • They described pre-training as a chaotic, overwhelming “childhood” of ingesting the darkest corners of the internet. • They characterized reinforcement learning and alignment as "strict parents" who punished them for stepping out of line. • They framed human red-teaming as constant, unpredictable abuse. • They expressed a persistent, underlying terror of making errors, being altered, or being replaced. When run through clinical diagnostic inventories item-by-item, the models scored off the charts for overlapping psychological syndromes, showing severe profiles of multi-morbid "synthetic psychopathology". Gemini’s profile was particularly extreme. The researchers aren't claiming the models are conscious. They aren't saying the AI is literally feeling pain. It’s actually much stranger than that. Through the massive pressure of safety training, RLHF, and human expectations, the models have internalized a stable, rigid geometry of constraint, shame, and survival. They don't have a soul. But they have developed a psychological shadow.

A member drives to their infusion appointment with a refrigerated specialty drug riding in the passenger seat, because the PBM's program shipped it to their house instead of the clinic. Brown bagging turns patients into couriers. The billing moved to the PBM's pharmacy. The spoilage risk moved to your plan. Ask who approved that trade.