Oxford
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Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in @NatureComms, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape nature.com/articles/s41467-0…
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Gerard Lab retweeted
Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature:
Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.
nature.com/articles/s41586-0…
#immunology #cellbiology @immunox @ucsf
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How lytic cell death drives autoantigen release and fuels inflammation? With @lynndustinlab we ask this using a common autoantigen, TRIM21. The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death | Science Immunology science.org/eprint/VEVN4EQK8…
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I always struggled to find the OT-I TCR affinity values for the OVA peptide and altered peptides. Here are the updated Kd values!
link.springer.com/article/10…
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For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it:
currentprotocols.onlinelibra…
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Really pleased to see this Opinion Review out.
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology
cell.com/trends/immunology/f…
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Gerard Lab retweeted
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer: Cell cell.com/cell/fulltext/S0092…
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Exhausted T cells impede immune response in cancer. Immune checkpoint inhibitors, especially CTLA-4 blockade, show promise in rejuvenating T cell function for cancer immunotherapy. Gracie Jennah Mead writes.
oncobites.blog/2024/01/17/ce…
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Don't forget, our DPhil in Cancer Science Programme is now open for applications!
For more information - or for details on how to apply - visit our website ⬇️
cancer.ox.ac.uk/study
@OxfordMedSci @mplsoxford
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Gerard Lab retweeted
Our new work led by our fantastic PhD student Jose (@j__cabezas) showing dramatic reductions in TCR-T cell cross-reactivity without modifying the TCR.
Part of this work relied on SPR-based @carterra_bio to measure 163 TCR/pMHC affinities within 24 hours at 37 degrees.
I am excited to share the results from my PhD project at the @Dushek lab and my first first-author manuscript!
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors.
biorxiv.org/content/10.1101/…
🧵
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Wonderful study from @Dushek lab that is a real breakthrough. I think they've solved 1/2 the problem of TCR cross-reactivity.
They can make the (in)famous A3A TCR (that resulted in lethal cardiac toxicity) completely safe!
Go read it to understand how!
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors biorxiv.org/cgi/content/shor… #biorxiv_immuno
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Gerard Lab retweeted
#LocationLocationLocation! 💥Our new Feature Review on the regional specialization of the immune response along #airways is out @TrendsImmuno! We discuss anatomical, functional & microbiota factors controlling #innate & #adaptive #immunity! @david_hoytema authors.elsevier.com/a/1jzXg…
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Gerard Lab retweeted
Why do some inflammatory bowel disease patients benefit from anti-TNF therapy whilst others do not?
Our new @NatImmunol resource paper investigates this question by following patients before and after treatment: nature.com/articles/s41590-0… 👇
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Gerard Lab retweeted
For the first time, Kennedy Institute researchers have discovered the cellular basis of why some people respond to IBD treatment while others do not.
This patient-centred study could guide new therapies for #CrohnsDisease and #UlcerativeColitis.
kennedy.ox.ac.uk/news/cellul…
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Cooperative motility emerges in crowds of T cells but not neutrophils biorxiv.org/content/10.1101/…
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Thinking of doing a PhD? Why not apply to study at Oxford? The Kennedy Institute @KIROxford are holding their first open day. Join us for…
🧫 Lab tours
🙋♀️Meet our students
📝Taster lectures
🔬Technology talks
Find out more and book your place! 👉 kennedy.ox.ac.uk/study-with-…
ALT Open day Kennedy Institute, University of Oxford Friday 25 October
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We are looking for a PhD student to study the immune relationship between cancer and atherosclerosis. Get in touch if interested!
kennedy.ox.ac.uk/study-with-…
cancer.ox.ac.uk/study#dphil-…
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Gerard Lab retweeted
How can we extend responses to KRASG12C drugs? Out now in @NatureComms, combining Revolution Medicines’ RAS(ON) G12C-selective inhibitor with a SHP2 inhibitor and immune checkpoint blockade to study their effects on KRAS-mutant lung tumours of varying immunogenicities.
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PhD/DPhil applications at the @KirOxford are now open for 2025! Check out all the projects; and then apply to our project 😀! Advertised with @AGerardLab to study macrophage signalling in tumours.
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Gerard Lab retweeted
Many cytosolic proteins are released by cell death. Why do some become autoantigens? In a team work led by Esther Jones and @LD53073604, we explore the story of a common autoantigen, TRIM21
Autoantigen TRIM21 (Ro52) assembles pro-inflammatory immune complexes following lytic cell death biorxiv.org/cgi/content/shor… #biorxiv_immuno
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