Malcolm Sim@mjwsim

MRC Career Development Fellow - group leader @UniofOxford. Medical Research Fellow @CorpusOxford. Also on mjwsim.bsky.social opinions my own

 England, United Kingdom
researchgate.net/profile/Mal…
Joined October 2014
95 Photos and videos
Really pleased to see this Opinion Review out. The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology cell.com/trends/immunology/f…
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Romagnani Lab@RomagnaniLab
Sep 20
Excited to share our new preprint! We use somatic mutations to show how a central principle of adaptive immunity - clonal selection - shapes innate immune memory to viral infection. A huge thanks to all co-authors and collaborators! biorxiv.org/content/10.64898…
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Prof. Nikolai Slavov
@slavov_n
Sep 15
Millions of PBMCs have been analyzed by scRNA-seq. Have we seen it all ? We profiled thousands of single PBMCs — proteomes and transcriptomes side by side — and uncovered functional coordination undetectable in the deepest scRNA-seq we could perform. biorxiv.org/content/10.64898… 1/
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Matt Bors@MattBors
Sep 14
It was exactly ten years ago today, on my 33rd birthday, that I posted this comic online.
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Elizabeth McKenna@ElizSMcKenna
Sep 2
The academic year has just started, and it's time - roll call for all new #cancer PIs who just started their labs! Please say hi and what you work on (or drop your lab website) so I can follow you if I don't already! 😃 #NewPI
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Ollie Harrison@harrison_oj
Sep 1
We've been quiet, but we've been busy! Delighted to share that in recent weeks we have received 3 NIH R01s to continue our studies of adaptive immunity in the gut! As such, we are recruiting post-docs with strong interests and expertise in mucosal immunology and (1/3)
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Anirban Maitra@Aiims1742
Aug 27
Final version of @NeehaZaidi paper on Mutant KRAS Vaccine for #PancreaticCancer interception in high risk cohorts out in @CD_AACR. aacrjournals.org/cancerdisco… Notable data is detection of KRAS antigen targeted T cells 1 year post vaccine - annual boosters as a prevention strategy?
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New single cell buzzword alert 🚨 ‘immune panorama’ 🚨 Double points for also using atlas in the title and landscape in the graphical abstract.
Waggoner Lab@LabWaggoner
Aug 25
A single-cell transcriptomic atlas reveals the immune panorama of neonatal sepsis @CellReports cell.com/cell-reports/fullte…
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1/2 Garcia Lab preprints out now - "Functional Pairing of TCR-pMHC Interactomes by Single-cell Clonal Expansion" led by @LiuDaisyLiu. Super cool tech!
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Paul Bieniasz@PaulBieniasz
Aug 18
Our new preprint on the origin of insertion mutations (including furin cleavage sites) in coronaviruses
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Waggoner Lab@LabWaggoner
Aug 11
Congrats, @colpitts_sarah @UofT ! Spatial and functional specialization of human splenic innate lymphoid cells (#ILC #NK) nature.com/articles/s41467-0…
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@compchemm
Aug 9
Mother of the ribbon diagram One paper in 1981. Changed how we see proteins. If you haven’t read it, you’re late. doi.org/10.1016/S0065-3233(0… #compchem #phd
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Waggoner Lab@LabWaggoner
Aug 6
Replying to @biorxivpreprint
@biorxivpreprint @OnfeltLab The solid tumor microenvironment changes the hierarchy of CD155 and CD112 receptors, shaping checkpoint blockade outcome biorxiv.org/content/10.64898… @karolinskainst
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JCI insight
@JCI_insight
Jul 28
Exciting possibilities for immunotherapy in HIV: doi.org/10.1172/jci.insight.… Andrew J. McMichael @GMAGillespie & team @UniofOxford used a high-affinity modified HIV-1 peptide to prime HLA-E restricted T cells, inhibiting HIV-1 replication in vitro. The figure: AHLA-B*57:01–restricted TCR transductants (AGA1) exhibited antiviral activity. #HIV #Immunotherapy
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Waggoner Lab@LabWaggoner
Jul 23
KRASG12D inhibition remodels the immune environment to favor NK cell activity and sensitizes cancer cells to NK cell killing science.org/doi/10.1126/scia…
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Great paper
Waggoner Lab@LabWaggoner
Jul 22
KIR Expression Defines a Transcriptionally Distinct CD8+ T-cell Population that Confounds Antigen-Specific T-cell Detection @biorxivpreprint biorxiv.org/content/10.64898… 🇩🇰
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Waggoner Lab@LabWaggoner
Jul 22
Teritary lymphoid structures harbor tumor-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies @Nature @NatureBiotech @harvardmed @broadinstitute @Yale nature.com/articles/s41586-0… nature.com/articles/s41587-0… nature.com/articles/s41587-0…
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Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/scie…
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Waggoner Lab@LabWaggoner
Jul 16
Direct interaction of Vδ7 TCRs with IL17RA drives the differentiation of TH1-like γδT cells @ScienceMagazine @TKreslavsky @karolinskainst science.org/doi/10.1126/scie…
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Why is empathy with tall people so difficult? (6ft4)
Jill Filipovic
@JillFilipovic
Jul 12
As a personal rule I recline on long flights (4.5 hours or more) but not on shorter ones. But I also don’t get mad at recliners. The seats recline! No one is being sneaky. Why are we mad at people for using the seat the way it was designed?
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Waggoner Lab@LabWaggoner
Jul 11
Replying to @biorxivpreprint
@biorxivpreprint Tumor microenvironments impose translational repression that limits NK cell persistence biorxiv.org/content/10.64898… @DavidFinlayTCD @tcddublin
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