Waggoner Lab@LabWaggoner

Research lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer. @labwaggoner.bsky.social

 Cincinnati, OH
Joined August 2018
14,045 Photos and videos
Waggoner Lab retweeted
Nature Rev Immunol@NatRevImmunol
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The next big questions in immunology dlvr.it/TVf2tH

The next big questions in immunology

Nature Reviews Immunology - As Nature Reviews Immunology marks its twenty-fifth anniversary, leading immunologists reflect on the questions, challenges and conditions that will shape the future of...

nature.com
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An AI-designed IL-21 mimic synergized with KRAS inhibition to drive durable tumor remissions in KRAS-mutant pancreatic cancer models through cDC2s, effector CD4 T cells, and IFN-γ - independent of CD8 T cells, cDC1s, or tumor MHC expression @CellCellPress cell.com/cell/fulltext/S0092…
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Fibroblasts restrain gut inflammation by IGF1-dependent regulation of innate lymphocytes @ScienceMagazine science.org/doi/10.1126/scie…
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Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates @ScienceMagazine @CedricFeschotte @Cornell @UTArlington 🇨🇳🇺🇸 science.org/doi/10.1126/scie…
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The AR-Gβγ signaling axis therefore represents a druggable target for cardiac fibrosis science.org/doi/10.1126/scie… @ScienceMagazine @Stanford @Joseph_C_Wu
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Exposure to high dietary fat increases ceramides and promotes cancer metastasis @ScienceMagazine @SwagataGoswam16 @EinsteinMed @ohyilmaz @Nilay_Sethi @DanaFarber science.org/doi/10.1126/scie…
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Mammalian cells produce and store a sulfur compound for antioxidant protection @ScienceMagazine @Sulfur_Vladi science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
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Targeting senescence decreases fibrosis and boosts the response of cancer cells to immunotherapy @ScienceMagazine @LoweLabMSKCC @Clemens2Hinterl @vBarthet @Dan_A_Heller @WeillCornell science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
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Feature @ScienceMagazine A little-known arm of the immune system responds to lipids, with a protein called CD1 driving reactions to bee stings, bacteria, and possibly poison ivy science.org/content/article/…

Little-known arm of immune system could be key to better vaccines, cancer therapies

The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy

science.org
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First Amendment challenge to NIH grant screening argues that Trump policy of purging politically sensitive terms from research projects violates free speech science.org/content/article/… @jocelynkaiser @ScienceMagazine

Researchers file First Amendment challenge to NIH grant screening

Lawsuit argues that Trump policy of purging politically sensitive terms from research projects violates free speech

science.org
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Single wildfire smoke exposure in infant macaques causes lasting harm (immune changes and signs of faster aging) @ScienceMagazine @biorxivpreprint biorxiv.org/content/10.64898… @MariamOkhovat @OHSUNews science.org/content/article/…
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Spatiotemporal assembly of the human ribosome science.org/doi/10.1126/scie… @ScienceMagazine @EMBLHeidelberg
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$174 million, 5-year initiative to fund training, tools, research grants, and other efforts to make rigorous research methods and replicating experiments a routine part of scientists’ work @NIHDirector_Jay @ScienceMagazine science.org/doi/10.1126/scie… science.org/content/article/…

Verification makes discovery matter

The existing research ecosystem in the United States often treats publication, particularly of new or positive results, as the primary marker of success. To move the scientific enterprise onto a...

science.org
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Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion @Nature @hongbo_chi @StJudeResearch nature.com/articles/s41586-0…
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TRAM promotes Toll-like-receptor-free myddosome signal transduction @nature @jkagan1 nature.com/articles/s41586-0… @BostonChildrens
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Waggoner Lab retweeted
John Lukens@LukensJohnR
Sep 24
Resident tissue macrophages transfer selenium transporter protein to protect pancreatic cancer from ferroptosis: @CellCellPress cell.com/cell/fulltext/S0092…
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First day of #NK2026 was capped by keynote lectures from giants of innate immunity: Trinchieri & Mantovani. Then we were treated to an amazing orchestral tour through Italian composer scores for major films, including Nino Rota and Ennio Morricone.
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Waggoner Lab retweeted
Caroline Sokol MDPhD@sokol_mdphd
Sep 23
1/ Why can you encounter an allergen repeatedly before becoming allergic to it? In our new @ImmunityCP paper, led by the wonderful @XuepingZhu, we asked whether the sensory neurons that first detect allergens might carry a record of earlier exposures. 🧵 cell.com/immunity/fulltext/S…

Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic...

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-depende...

cell.com
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Waggoner Lab retweeted
John Lukens@LukensJohnR
Sep 23
Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more nature.com/articles/d41586-0… @Nature
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Great 2nd session 'Oncology' at #nk2026 in beautiful Monopoli includes talks from Yenan Bryceson, Mike Caligiuri, @MalmbergLab et al covering oncolytic virus/NKCE combos in GBM, mitochondrial and ER fitness of killer cells, chemo CAR-NK synergy & NK traits of CD8 T
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