Director, Immunology Institute @SinaiImmunol @IcahnMountSinai | Harnessing the innate immune system for novel therapies against cancer & inflammatory diseases.
Manhattan, NY
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In this article, I argue that pandemics, antimicrobial resistance, cancer, inflammatory diseases & aging are among the greatest threats to our societies. Yet biomedical research receives a fraction of military spending, when in fact the #NIH is also a “Department of Defense”.
Academic biomedical research is national defence dlvr.it/TTtvVc
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I enjoyed contributing to this @nytimes piece on the role of macrophages in driving inflammation, how chronic inflammation contributes to many major human diseases, and the growing potential of targeting inflammation to prevent and treat disease. @SinaiImmunol #Inflammation
How does chronic inflammation shape our risk for cancer & other diseases as we age? 🔬
Great piece in the @nytimes exploring the latest science, including insights from @MiriamMerad, who was recently awarded funding by @TheMarkFdn, @WaxmanCancer, & @AmericanCancer to study inflammation & aging. nytimes.com/interactive/2026…
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Very pleased to share this new commentary on the extraordinary biology of resident tissue macrophages (RTMs). RTMs are the most evolutionarily conserved immune cells. They emerged before adaptive immunity and blood circualtion (1/4) rdcu.be/fusPs
Macrophages are constitutive architects of tissue integrity dlvr.it/TTZnG2
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I also discuss how RTMs decline with age increases susceptibility to severe infections, and organ dysfunction with age & argue that RTMs are untapped therapeutic targets and that harnessing TM could transform disease prevention, tissue regeneration, and healthy aging. (3/4)
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Very grateful to @FGinhoux, @MartinGuilliams, @MatthewD_Park, @samhegde2006, and @naderyatim for the insightful discussions and input that helped shape this commentary. (4/4)
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Beautiful study showing that aging leads to resident tissue macrophages (RTM) decline in number and function. EP2 deletion restores RTM phagocytic capacity and clearance of senescent neutrophils, reduces chronic inflammation, and improves cognition, muscle & cardiac function 1/2
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This aligns remarkably well with our work showing that age-associated RTM decline drives organ dysfunction, as discussed in our recent review (DOI: 10.1038/s43587-025-00898-y). We have now started to translate these concepts toward clinical translation. science.org/doi/10.1126/scie…
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Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/scie…
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Many thanks to our colleagues for their intellectual insights, collaboration and generosity @NikJoshi @KamphorstAlice @BcellBruno @HeleneSalmon - It was a pleasure working with you all.
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Important read and highly relevant to both academia and industry
A terrific perspective from Ivan Dikic
linkedin.com/feed/update/urn…)
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A great discussion with the fantastic @DrTomMarron @SinaiImmunol @TischCancer, beautifully filmed by @noabaker, on our work to decode how inflammation drives cancer initiation and how we can prevent cancer before it starts (1/2)
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Our goal is to prevent cancer using safe immunomodulatory therapies, perhaps even a pill, in people at risk. If we succeed, preventing cancer could become one of the greatest public health achievements of our generation.piped.video/bVCE-7UUFGE?si=h-ga…
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Remarkable study from Irv Weissman and colleagues @StanfordMed showing that macrophage-mediated xenophagocytosis is a key barrier to interspecies chimerism and that blocking it enhances donor engraftment. (1/2)
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A major step toward transplantable human organs and a reminder that macrophages are the guardians of biological identity. Beautiful !
sciencedirect.com/science/ar…
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Congratulations to @jeremiahfaith1, @grinsa01, and @sinaiimmunology on a big milestone in microbiome therapeutics: nature.com/articles/s41591-0… (1/2)
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in this Phase 1b trial: they show that a defined 15-bacterial strain manufactured in house @IcahnMountSinai achieved similar safety, durable engraftment, and efficacy than FMT in recurrent C. difficile infection. An important step toward standardized, scalable microbial medicines
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Extraordinary advances #ASCO2026 in deadliest cancers show that cancer cures are increasingly within reach. Biggest limitation now is not science, but funding. We need a stronger NIH to remain at the forefront of discovery and keep fighting for US lives. #doubleNIHBUDGET
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Quite an extraordinary study showing that liver macrophages in pigeons communicate with brain neurons via the vagus nerve to control avian navigation. Another example of macrophages evolutionary ability to sense and interface with their external environment
For those of you who think macrophages do almost everything, rethink “almost.”
They are programmable cells, recruited into whatever new function evolution needs.
science.org/doi/10.1126/scie…
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