Partnering with scientists to accelerate transformation in cancer research
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“The Mark Foundation is different from other organizations. All types of cancer are in scope for us, and that was by design, from the beginning.”—Ryan Schoenfeld, CEO
Watch our new video to learn how we are accelerating progress in the fight against cancer.
vimeo.com/1013135446
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Alongside @AACR and @lustgartenfdn, we're proud to support work by Dr. Aguirre and his collaborators to target RAS early, before deadly cancer has a chance to take hold. themarkfoundation.org/portfo…
Andrew J. Aguirre discussed "Targeting RAS in Pancreatic Cancer" in a keynote lecture to open the AACR Conference on New Frontiers in the Biology of and Therapeutic Development for Pancreatic Cancer.
#AACRpan26
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Exciting new paper from Endeavor Awardee Scott Lowe!
Excited to share our new paper, out today in @ScienceMagazine! We developed senescence-modulating nanoparticles (SMNPs) that target P-selectin+ pathogenic senescent-like macrophages in fibrotic tissues and tumors.
science.org/doi/10.1126/scie…
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Breakthroughs don’t happen by playing it safe. This #WorldCancerResearchDay and every day, we back the bold scientists changing the future for cancer patients. 🔬Join us in fueling the next discovery: themarkfoundation.org/donate…
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The Mark Foundation for Cancer Research retweeted
Very grateful for the support of @TheMarkFdn to pursue our biggest and boldest ideas!!
#BloodCancerAwarenessMonth #JAXresearch #JAXstemcellsdev
This #BloodCancerAwarenessMonth, we’re spotlighting 2023 Emerging Leader Award winner Jennifer Trowbridge (@TrowbridgeLab) of @JacksonLab. She’s looking for answers to a big question: why aging blood cells develop into cancer in some individuals but not others.
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The Mark Foundation for Cancer Research retweeted
We're proud to fund @TrowbridgeLab & @vangalenlab as they investigate how age-related inflammation may fuel blood cancers—and uncover potential paths to prevention. This is why connecting aging biology & cancer research matters! with @TheMarkFdn #BloodCancerAwarenessMonth
Understanding how shifts in our cells impact aging and cancer resistance is a critical step toward developing strategies that can intercept blood cancers before they ever take root. Learn more about her research: themarkfoundation.org/portfo…
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This #BloodCancerAwarenessMonth, we’re spotlighting 2023 Emerging Leader Award winner Jennifer Trowbridge (@TrowbridgeLab) of @JacksonLab. She’s looking for answers to a big question: why aging blood cells develop into cancer in some individuals but not others.
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In a recent study published in @GenomeBiology, Dr. Trowbridge & collaborators mapped how human blood stem cells change over time, revealing a distinct group of inflammation-prone cells that expands with age and may drive susceptibility to cancer. link.springer.com/article/10…
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Understanding how shifts in our cells impact aging and cancer resistance is a critical step toward developing strategies that can intercept blood cancers before they ever take root. Learn more about her research: themarkfoundation.org/portfo…
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How do our genes shape lung cancer risk?
A landmark study co-led by Mark Foundation grantee Pasi Jänne of @DanaFarber sheds new light on the question—and in the @nytimes, our Board Chair @rndubois offers a key clinical perspective.
nytimes.com/2026/09/17/scien…
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As @rndubois told @ginakolata, uncovering these drivers is vital for early detection and prevention, opening the door to screening for at-risk patients who might otherwise be overlooked by traditional, smoking-based criteria.
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Dr. Jänne is tackling lung cancer on multiple fronts: separate from this study, his Mark Foundation Drug Discovery project with Michael Eck & David Scott—a next-gen EGFR inhibitor for resistant #NSCLC—is on its way to Phase 1 trials. themarkfoundation.org/portfo…
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Could delivering weeks’ worth of radiation in seconds reduce toxicity? This month, @PennCancer launches a groundbreaking trial of FLASH radiation, developed with support from The Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation.
inquirer.com/health/radiatio…
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The new modality delivers radiation 100+x faster than traditional therapies—and in preclinical models, it promotes faster tissue recovery with less damage to healthy tissue. Trial doctors hope that FLASH radiation provided to head & neck cancer patients will reduce or eliminate harsh side effects induced by standard radiotherapy regimens.
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Learn more about the multidisciplinary work, including on FLASH radiation, that The Mark Foundation has supported at @upenn: themarkfoundation.org/blog/e…
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Great commentary from our Scientific Advisory Committee member @CharlesSwanton !
#Comment🚨
Swanton&Co @CharlesSwanton highlight the histories of EGFR, HER2, CDK4/6 and RAS, and discusses how sustained investment in discovery science continues to generate clinical benefit through new drugs, indications and treatment combinations.
📖⬇️
dlvr.it/TVPRKl
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25 years on, cancer cases among 9/11 survivors are rising fast. Half of all survivors in the World Trade Center Health Program now receive treatment aid, up from 35% five years ago.
More from @danswu & @chrishnews in @wapo:
washingtonpost.com/health/20…
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Why the surge now? Cancer can take decades to develop, and the aging process plays a major role.
As the body ages, its immune defenses weaken and DNA repair slows, allowing dormant damage from earlier toxic exposure to develop into malignancy.
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