Clinician scientist training is under threat: this analysis reviews the outcomes of a 25 yearcohort of the UCL MB-PhD program from 1995 : a long-term investment in the clinician-scientist workforce medRxiv medrxiv.org/content/10.64898…

📢 Two new Cancer Grand Challenges 📢 We're calling on international, multidisciplinary research teams to come together and propose bold, innovative approaches to some of the most complex and pressing challenges in gastroesophageal cancer. With more than 1 million lives lost to gastric and oesophageal cancers each year globally, the need for bold new solutions has never been greater. Applications close 24 November. Discover the new challenges: bit.ly/4xfm78b Winning teams will be funded by the Torrey Coast Foundation and Cancer Research UK (CRUK), through Cancer Grand Challenges.

🚨 Amazing news from @CancerGrand @CR_UK! Two new cancer grand challenges in UPPER GI CANCERS! cancergrandchallenges.org/ap… cancergrandchallenges.org/ap… Up to $34 million in awards for global teams! Apply now and spread the word. @CharlesSwanton

The rumors are true! I am beyond excited to take on this new adventure as the inaugural chair of the Systems and Computational Biology (SCB) Department at @WeillCornell thread 👇

Register today for the Cancer Research UK Lung Cancer Centre of Excellence Conference, 4-6 November 2026, Manchester, UK. Hear from some of the world's leading researchers and clinicians on the latest in lung cancer research. See you there. cruklcce.org/

This was tilmed yesterday at the community adoption event in San Diego, California. The dog is Duke, a 10-year-old German Shepherd being showcased for adoption. The veteran is Tech Sergeant James Parker, 39, Air Force, walking through the parking lot heading into the store. Duke served with James in Afghanistan from 2011-2013. When Duke retired from military service two years ago, James couldn't adopt him immediately-rental restrictions. Duke went into the adoption system. James had been searching for months through databases. Yesterday, James was at the pet store buying supplies. Had no idea there was an adoption event happening. Duke was sitting with volunteers at the outdoor table. Watch what happened. James walks through the parking lot. Duke's head snaps up. Sees James. Goes completely rigid. Staring. Then breaks into a full sprint. Rips the leash from the volunteer's hand. Runs straight across the parking lot. Launches into James's chest. Both crash to the ground. Duke frantically checking James's face with his nose. Whining. Tail going insane. James wrapping both arms around Duke. Sobbing. "I've been looking everywhere for you. Everywhere." Volunteer told us: "Duke saw James and just took off. The recognition was instant. l've never seen anything like it." James adopted Duke immediately. Took him home yesterday. Ten years after serving together. Found by complete chance in a parking lot. James told us: "I searched every database for months. Never expected to find him at a random pet store. But Duke found me." Sometimes the reunion you're desperately searching for happens when you're just buying dog food.

🚨 Results from #LITESPARK022 (#LS022) are out in @NEJM! 1/This phase III trial evaluated whether adding the HIF-2α inhibitor Belzutifan (BEL) to adjuvant pembrolizumab (PEMBRO) could improve outcomes for patients with resected clear-cell RCC at increased risk for recurrence. nejm.org/doi/full/10.1056/NE… @oncoalert @asco @myESMO

Our new tree paper is live @NatureGenet 🌳🥳🌳 ! Check out the tweetorial/Xplainer below and the open link in first comment. Lovely and inspiring collaboration with @MarioSuva to harness phylogenetic reconstruction of patient samples to decipher glioma evolution & progression.

The Boston Globe has dedicated a full page in today's edition to the Tartan Army 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🇺🇸 The letter in Boston's largest newspaper reads: "Dear Tartan Army, "You came for the World Cup, but gave us something more. "For a week, you turned train stations into singalongs, Fenway into a football ground, and an ordinary June into something we'll be talking about for years. "Boston has hosted championships, parades, and celebrations of every kind. But we've never hosted guests quite like you all. "Thank you for the laughter, the bagpipes and the memories. The World Cup will move on. So will the songs, but we'll never forget the joy you brought to our city." 𝘐𝘯 𝘱𝘢𝘳𝘵𝘯𝘦𝘳𝘴𝘩𝘪𝘱 𝘸𝘪𝘵𝘩 @SPARScotland 𝘐𝘔𝘈𝘎𝘌: 𝘕𝘦𝘸𝘴𝘲𝘶𝘦𝘴𝘵

For sale: treadmill, one careful owner! After 15 years of using a treadmill desk in the @sciencemuseum I'm sadly having to say goodbye - the victim of an office reorganisation.  Would anyone like to bid something to give my machine a good home? linkedin.com/posts/roger-hig…

He fed all 150 of us before he made himself a plate. Friday the 13th. United flight 2480, San Francisco to Houston. Somewhere over New Mexico, a passenger collapsed in the bathroom. The plane went quiet in that particular way, the kind where strangers who will never know each other's names start silently praying for the same person. We made an emergency landing in Albuquerque. An ambulance was already waiting on the tarmac. That should have been the story. But the delay pushed our crew past their legal flying hours. FAA rules. Nobody's fault, just the math of safety regulations meeting a long, hard day. A new crew had to fly in from Chicago. We weren't leaving until almost 10:30 that night. Seven extra hours. In an airport. With cranky kids, empty stomachs, and the particular exhaustion of watching a short delay quietly turn into an entire evening you didn't plan for. United sent meal vouchers. Eventually. 7:15 p.m. Every restaurant in the terminal was already closed. 150 people. A stack of useless paper. Nowhere to spend it. That's when our captain picked up his phone. He didn't ask corporate. Didn't wait for approval. Didn't make an announcement to the gate so everyone would know what he was about to do. He just called a local pizza place and ordered 30 pizzas. Out of his own pocket. When the boxes arrived, he didn't hand them off to a gate agent and walk away. He organized a line, by seat number, the only fair way to do it, and stood there in his full captain's uniform, serving slices to exhausted strangers one at a time. When a box ran out, he broke it down and opened the next one. He fed all 150 of us. Then, and only then, he made himself a plate. Before we finally boarded the replacement flight, he stood at the door and shook the hand of every single passenger as they walked past him to their seat. Every one. I've flown more flights than I can count. I have never seen anything like this. Nothing about that night was in his job description. Nobody would have faulted him for handing out vouchers and disappearing into the crew lounge to rest. He had every reason to be as tired as the rest of us. He chose to be the one still standing, still serving, still making sure 150 strangers felt like someone in that building actually cared whether they ate. That's not customer service. That's just who he is when no one's required to be. To the captain of Flight 2480, somewhere out there, you probably don't think this was a big deal. It was. 🍕✈️

Beautiful chart: the collapse in cardiovascular mortality over the last 100 years What happens when we add anti-lipoprotein(a), anti-IL6, anti-NLRP3, oral anti-PCSK9...?

What if we could predict cancer 5+ years ahead and prevent it? A new landmark study shows the way

Getting to the root of age-related diseases. By studying a rare accelerated aging genetic disorder, gain-of-function mutations of DNMT3A were found to be causal. DNA hyper-methylation was then linked to stem cells dysfunction and multiple age-related diseases (blood, bone, metabolic). Work in mice and humans. @NatureGenet nature.com/articles/s41588-0…

🔥14-protein plasma signature predicts lung cancer >5 years before diagnosis 🆙 @CellCellPress ☑Analysis of 48,000+ samples; validated across 8 cohorts 🎯Anti-IL-1β therapy stratified by signature lowers NNT for prevention 🎙Dr. Tej Pandya @CharlesSwanton #LCSM @OncoAlert @Larvol cell.com/cell/fulltext/S0092…

The primary is the source of first progression in >50% of cases of #lungcancer patients, and TRACERx showed us that in 32% of NSCLC the primary polyclonally seeds metastases. In our @IASLC consensus, now in JTO shorturl.at/GzAe2, makes the case for eradicating it with #radiotherapy. The EGFRm phase III data are the most compelling OS 34.4 vs 26.2 months with TKI+RT. There are still unresolved questions in the non-AGA population. We are opening the phase III PRIME-LUNG trial shorturl.at/26apO @TROGfightcancer @TOGAANZ to answer this question! #radonc

Thanks, this 14-protein plasma signature predicting IL-1β responsiveness years ahead of lung cancer diagnosis is genuinely exciting. How do you see it reshaping early detection strategies for people across all risk levels?

The striking part isn’t just that a 14‑protein panel can flag lung cancer risk >5 years out, it’s that the signal is so IL‑1β‑centric. That neatly retrofits the CANTOS “accident” where canakinumab cut lung cancer incidence and mortality. We’re basically watching systemic inflammation turn the lung microenvironment pro‑tumor long before a nodule appears on CT. The next step isn’t more imaging, it’s immunoprevention trials in the high‑signature group.

A very impressive study for how we could prevent lung cancer more than 5 years before it is diagnosed. Using machine learning, discovery of a 14-plasma protein signature of risk that predicts responsiveness to an antibody therapy to interleukin, IL-1β Validated across 8 cohorts @CellCellPress @CharlesSwanton cell.com/cell/fulltext/S0092…

If helpful to understand the importance of this study, I made an infographic with @NotebookLM