I've said many times mechanical hypertrophy is harmful for our health because it suppresses metabolic adaptation via JNK. You have more muscle at the expense of your health (mitohondria). link.springer.com/article/10… karger.com/ger/article-abstr… frontiersin.org/articles/10.…

Exercise-mimicking effect of exogenous lactate administration: promoting visceral fat reduction via ventromedial hypothalamic SF-1 neurons in female rats | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society journals.physiology.org/doi/…

Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians mdpi.com/1422-0067/27/18/842… @IJMS_MDPI Figure 1. Sex-associated immunological mechanisms contributing to stronger antiviral responses to influenza in females than in males.

Beneficial early, harmful later: age-dependent effects of testicular factors on male mortality “Here, we castrated UM-HET3 males before puberty (20 days), after puberty (60 days), or immediately before the typical rise in male mortality (240 days). Castration at all three ages prevented the early male mortality and increased median lifespan by 19.3%, 25.8%, and 32.9%, respectively… [Additionally] “Remarkably, castration at 240 days not only preserved the survival benefit of earlier castration but produced significantly greater survival than earlier castration, suggesting that testicular exposure before 240 days is actually beneficial… “ Longitudinal body-composition measurements further revealed that castration shifted males toward a female-like phenotype, characterized by reduced lean mass and continued fat accumulation into later life.” biorxiv.org/content/10.64898…

Effects of Resistance Training Sets on Cognition and Brain-Derived Neurotrophic Factor in Cognitively Impaired Individuals: A Quasi-Experimental Study pubmed.ncbi.nlm.nih.gov/4267…

Associations between wearable-device-measured daytime and nighttime light exposures and dementia risk: A prospective cohort study “High levels of daytime light exposure were significantly associated with lower dementia risk…” onlinelibrary.wiley.com/doi/…

Association between tight underwear and semen quality in men seeking fertility evaluation: an exploratory analysis of sexual dysfunction ovid.com/10.4103/aja202646

Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle fiber-type gene expression cell.com/iscience/fulltext/S…

Progressive Overload and Muscle Hypertrophy: Its Relation to Muscle Use in Training Session ovid.com/10.1519/JSC.0000000…

Cold activates a BH2 metabolic network promoting longevity and proteostasis nature.com/articles/s41586-0…

Time course of muscle hypertrophy with and without progressive overload pubmed.ncbi.nlm.nih.gov/4288…

Anabolic inequality among whole protein foods cdnsciencepub.com/doi/10.113…

In @eLife: The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch doi.org/10.7554/eLife.107597…

Why do large dogs tend to live shorter lives than their smaller counterparts? The answer may be written into their epigenome, according to a new study in Science. The findings reveal that larger and male dogs undergo accelerated molecular aging, with pronounced DNA methylation on the X chromosome and at transposable elements. Learn more: scim.ag/3VZtl3f

More sets ≠ more gains. 💪 A 12-week study in trained women found no significant advantage of increasing training volume every 2 vs. 4 weeks for muscle growth or strength. Progression doesn’t always require more sets. researchgate.net/publication…

Longer lipids mark aging and constrain lifespan 👉 “… we identify elongation of lipid acyl chains as a conserved hallmark of aging across mice, Caenorhabditis elegans, Drosophila and humans. Similar lengthening occurs during the progression of human heart disease, whereas dietary restriction shortens cardiac lipids in mice. Integrated analyses reveal that aging is characterized by a shift toward longer lipids accompanied by depletion of shorter species, indicating ratiometric remodeling. Following this, we identify the lipid remodeler Plb1 as a regulator of this process, with expression correlating with lifespan in mice and genetic analyses supporting a causal role in human frailty. In C. elegans, Plb1 knockdown reverses lipid elongation and extends lifespan in a lipid-length-dependent manner. Together, these findings establish lipid chain length remodeling as a conserved, actionable hallmark of aging.” 👨🏻‍⚕️nature.com/articles/s43587-0…

Recent paper from our group on muscle growth and local muscular endurance link.springer.com/article/10…

The Power of Analytical Meditation - His Holiness the Dalai Lama shares how decades of analytical meditation gradually transformed his own emotions, until attachment and anger nearly disappeared. The key, he explains, is not prayer but investigation: examining different, even opposing views and making full use of our intelligence to train the mind. Video originally recorded on February 5, 2017.

Acute Molecular and Chronic Vastus Lateralis Adaptations to Lengthened Partial versus Full Range of Motion Resistance Training in Trained Men ovid.com/10.1249/MSS.0000000…

Regional Hypertrophy of the Gluteal Muscles Is Task-Specific: Differential Responses to 10 Weeks of Hip Extension Versus Hip Abduction Training ovid.com/10.1519/JSC.0000000…

Elbow Flexor Adaptations to Failure Versus Repetitions-in-Reserve Training: A Unilateral Within-Participant Study in Resistance-Trained Adults mdpi.com/4056724 #mdpimuscles через @MDPIOpenAccess