It is worth playing both because they are two completely different characters. The lines may be the same, but the performance paints a very different picture. Of those two, I think he-V is clearly more fun.
She-V's delivery is aggressive and tense in almost every situation. She is sarcastic when discussing her weaknesses, and angry and confrontational when speaking with rivals.
He-V delivers his more fearful or intimate lines with sincerity and vulnerability, while always adopting a cocky, confident tone with rivals, the exact opposite of she-V.
The result is that she-V comes across as a scared kid lashing out. This isn't an inherently bad idea of a protagonist, but I much prefer he-V's seemingly bulletproof, Han Solo-esque charming rogue, who is doing his best to conceal his dread of his impending doom. He's both more charismatic and more complicated.
Which Cyberpunk 2077 V is better?
I actually have done more playthroughs as female V but Male V gets Panam tho…