Protein design & synthetic biology • Asst. prof. @ETH_BSSE
Basel, Switzerland
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Excited to share that I'll be starting a group @ETH_BSSE researching at the intersection of protein design, biology and AI. Come join us!
On the proposal of ETH Zurich President @Joel_Mesot
, the ETH Board appointed 12 professors and awarded the title "Professor of Practice" once. 👨🏫👩🏫 brnw.ch/21wF6YH @MortezaAramesh @ellliottt
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🚀 Interested in joining my group as a PhD or Postdoc?
I'm mentoring for the ETH AI Center's Doctoral and Postdoc Fellowship, working on biomolecular design.
If you're excited about AIxBio, I'd love to hear from you.
Apply now 👉 ai.ethz.ch/apply
Deadline: Oct 27, 2026
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Gen models for biomol design have improved by leaps and bounds, but wetlab val remains a bottleneck. Excited to share our work where we address this on the prot prod&purif (SAPP) and reducing input DNA costs (DMX). nature.com/articles/s41467-0…
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Basile Wicky retweeted
#JobAlert 🚀 Exciting opportunity for young scientists - please share: tinyurl.com/2rajyepc
@ETH_en #BIIE @BaselStadt
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We're hiring! If you're interested in applying protein design to improving AAV we'd love to hear from you! Fully-funded 2 year collab postdoc between my group at ETH D-BSSE (in Basel) and Denis Phichith at Roche.
Job description and application portal: lnkd.in/e3P7HXt4
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New lab preprint! We used design to sample protein space, and developed a HT NMR pipeline to analyze 384 designs; a first glance into seq-struct-dynamics at scale! An exciting collaboration with @HillerLab, and @DlanAbr's first paper! biorxiv.org/content/10.64898…
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Basile Wicky retweeted
Super excited to share our paper “Design of amyloidogenic peptide traps” is out now! 🧠
nature.com/articles/s41589-0…
Special thanks to @eaandrzejewska , Danny Sahtoe and David Baker
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Basile Wicky retweeted
Short summary thread of our recent review on de novo protein design:
(Poster-sized figure (36 x 48 inches) for printing: drive.google.com/file/d/1sG3…)
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Basile Wicky retweeted
I keep on preaching to my lab about the usefulness @ChatGPTapp for coding, but real-life demos might be more effective. A thread on a neural network we quickly developed to classify antibiotics sensitivity 🧵 (1/10)
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The commentary I wrote is now live at Nature Biotech: nature.com/articles/s41587-0… (free version rdcu.be/dwSSy).
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Continuous directed evolution is so cool 🥹
Excited to share - EcORep! Now you can simply electroporate a PCR product into E. coli and let the linear DNA replicate orthogonally in the cell. EcORep can be used to evolve proteins rapidly and continuously! science.org/doi/10.1126/scie…
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Basile Wicky retweeted
LigandMPNN preprint: biorxiv.org/content/10.1101/…
LigandMPNN inference code + model weights (including ProteinMPNN, SolubleMPNN etc): github.com/dauparas/LigandMP…
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Beautiful work by the talented @KieraSumida and Reyes! Their findings on the quantitative tradeoff between seq conservation, designability and function (fig. 3f/g) is particularly insightful, and will be useful for many future protein engineering efforts!
Our paper using ProteinMPNN redesign for improved properties is up on JACS! Huge thanks to Reyes, @ikalvet, Sam, and many others for their work. Shout out to @JustasDauparas for developing such a groundbreaking (and versatile!) tool. @UWproteindesign
pubs.acs.org/doi/full/10.102…
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Basile Wicky retweeted
#openposition Exciting opportunity for a #postdoc: be part of the partnership @ETH_en and @Roche and become a Next-Gen Bioengineer > u.ethz.ch/m4Lwj Thanks for sharing!
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Basile Wicky retweeted
Expanding protein pore palette beyond biology. Computational design of protein pores with various shapes and sizes. (Potential applications: Nanopore sensing, DNA/Protein sequencing, Custom pores for selective membranes and ligand-gated channels for cellular delivery.....)
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Basile Wicky retweeted
We are hiring! Come join us for a PhD in Computational Language Evolution @ETH in Basel @ETH_BSSE and the National Research Program on Evolving Language @NCCR_Language. We are looking forward to receiving your application jobs.ethz.ch/job/view/JOPG_e…
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Basile Wicky retweeted
We're looking for a PhD student interesting in protein design and tech development. Exciting project interfacing protein @structbiolbxl and solid-state nanopores @imec_int. Computational design of hybrid nanopore sensors. Apply by December 15th! imec-int.com/en/work-at-imec…
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Basile Wicky retweeted
Dorado v0.5 NCM release 🎉
- new simplex models
- faster
- higher accuracy
- easier to use (auto model selection)
- hemi-methylation (duplex mods)
- primer & adapter trimming
- custom barcodes
#nanoporeconf
github.com/nanoporetech/dora…
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Basile Wicky retweeted
Is binarization of scATAC-seq data really necessary? The conclusion from our analysis is that a quantitative treatment is in fact beneficial. Now out in Nature Methods! @gagneurlab @fabian_theis nature.com/articles/s41592-0…
Many additions since the preprint 👇(1/n)
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