Assistant Professor at UCLA in the Department of Biological Chemistry
- Tweets 237
- Following 733
- Followers 1,527
- Likes 1,553
Aparna Bhaduri retweeted
The Nano Lab is opening in the Dept. of BioSciences, Rice University, Oct 2026! 🧠🦉
We’ll be profiling and perturbing the molecular cues that shape the human brain using single-cell functional genomics and human cortical organoids.
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Congratulations to @MilJessenya and @Jalbsoto on their published paper, online now!! We are so excited that this is out!
cell.com/cell/fulltext/S0092…
Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. biorxiv.org/content/10.1101/…
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(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇
biorxiv.org/content/10.64898…
biorxiv.org/content/10.1101/…
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(4/5) Next: Meet the NVP (Neurovascular Progenitor) 🧬. This rare population co-expresses neural and perivascular programs. Using patient-derived lineage tracing, we proved NVPs can bridge the gap, giving rise to both neural and mesenchymal fates.
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I'm incredibly proud to be a part of the V Foundation's new PSA campaign because they’re 💯% in for Victory Over Cancer®!
The V Foundation gives 💯% of every dollar donated directly to lifesaving cancer research—no exceptions.
I'm so honored to be on this team!
We’re 💯% in for Victory Over Cancer®. We need to give everything we’ve got.
That’s why the V Foundation gives 100% of every dollar donated directly to lifesaving cancer research.
Our new PSA campaign showcases the incredible team it takes to achieve Victory Over Cancer®, featuring Cancer Survivor @chauntelowe and V Foundation Grantee, @BhaduriLab.
Give 💯% today: v.org/donate.
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So excited to share this paper led by @ShivaniBaisi_MD! Check out iHOTT!!
🧵Excited to share our new preprint introducing iHOTT - an autologous tumor-immune co-culture model that captures patient-specific responses in #Glioblastoma
💥Now on @biorxivpreprint: biorxiv.org/content/10.1101/…
📝From @BhaduriLab in collaboration with @UCLANsgy
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Excited to present our new preprint led by @claudianguyen95 uncovering how thalamic input shapes human cortical development! We discover that thalamic axons promote upper layer cortical neurogenesis through NRXN1-mediated contacts with outer radial glia. biorxiv.org/content/10.1101/…
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Our findings suggest that the early entry of thalamocortical afferents in human and nonhuman primate cortex mediates communication with cortical progenitors. This demonstrates that the human thalamus actively sculpts cortical architecture during early development! 🧩
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A huge thank you to the amazing collaborators and members of the Bhaduri Lab for their contributions to this study! Antoni Martija, @prnano9, @Jalbsoto, Dan Jaklic, @MilJessenya, Rista White, @JacquiMMartn1, Dakshesh Rana, @GeschwindLab
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Aparna Bhaduri retweeted
📢 Paper out! FCDII is more complex than expected - somatic mTOR-activating mutations affect multiple cell lineages, yet only a fraction become cytomegalic. Dysmorphic neurons show mitochondrial dysfunction. #Epilepsy #BrainMosaicism #Neurodevelpment
Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII)
@BaulacS @SaraBaldassari4 @KlinglerEsther @InstitutCerveau
nature.com/articles/s41593-0…
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Aparna Bhaduri retweeted
A new UCLA study leverages computational methods and existing data to bring us closer to answering the question: How does the brain build itself?
@dgsomucla
@UCLAHealth
@UCLAstemcell newsroom.ucla.edu/stories/cr…
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Aparna Bhaduri retweeted
Parallel meta-analyses of the human cortex in development (seven datasets) and adulthood (16 datasets) generated over 500 gene co-expression networks describing of cortical development, centering on peak stages of neurogenesis
@BhaduriLab @prnano9
nature.com/articles/s41593-0…
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