md-phd student with @jbloom_lab | viral evolution and ID | @uw_mstp @uwgenome @fredhutch
Seattle, WA
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So honored to have received this award! Thank you to Experiment Foundation and @navigationfund
I’d also like to note that @CKikawa was recently given a Beyond the Journal Award for the way she has been sharing these and similar data on GitHub in real-time as they are generated: experiment.foundation/beyond
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Caroline Kikawa retweeted
We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza
Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization & can inform choice of strains for next vaccine
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Caroline Kikawa retweeted
In new study led by @CKikawa, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains.
Data can inform vaccine selection & evolutionary/epidemiological modeling.
biorxiv.org/content/10.1101/…
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Caroline Kikawa retweeted
In new study led by @timcyuu, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape
We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints
biorxiv.org/content/10.1101/…
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Caroline Kikawa retweeted
In study led by @CKikawa & Andrea Loes, we use new assay to measure ~10,000 neutralization titers to recent influenza strains & show titers correlate w evolutionary success of viral strains
Similar data could help forecast evolution for vaccine selection
biorxiv.org/content/10.1101/…
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Caroline Kikawa retweeted
In new study led by Andrea Loes, we develop sequencing-based neutralization assay that measures replicate curves for hundreds of virus-serum pairs per 96-well plate (see image below)
biorxiv.org/content/10.1101/…
We apply assay to characterize response to repeat influenza vaccination
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My first, first-author research article was published yesterday in @JVirology! doi.org/10.1128/jvi.01414-23
Excited to share our work measuring the effects of single flavivirus mutations on antibody neutralization, led by me w/ @jbloom_lab and @lesliegoo_lab guidance
🧵...
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Overall, we found broad antibodies are harder to escape than targeted antibodies. We hope these data and further efforts to characterize Zika and dengue antigenicity aid vaccine/drug design.
Here are some other highlights from our paper. If you get a chance, please check it out!
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Thanks to awesome mentors Jesse and Leslie, collaborator @mateoinnyc, super lab mates Catiana, Jackson, @maya_contr, @LisaLevoir. Excited for the rest of grad school!
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