A group of cancer systems biologists originating from an NCI-sponsored program to foster integrated approaches to cancer research. Tweets our own.
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Closing remarks for #SACB2025 from Dr. Paul Macklin highlighting some of the dominant themes
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A great example from Dr. Melissa Kemp of data-driven multi-omic patient-specific models, used in this case to identify differences in NAPDH metabolism for radiation-resistant patients for head and neck cancers and also pancancer (TCGA) pmc.ncbi.nlm.nih.gov/article…
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Dr. Kemp reminding us about the importance of metabolism (redox processes, ROS) in head and neck cancers
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For our final talk, we have as a keynote speaker Dr. Melissa Kemp on cancer redox metabolism, information processing, and more #SACB2025
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Our final speaker in the signaling session is Dr. Todd Stukenberg talking about systems modeling of mitotic signaling in TNBC #SACB2025
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Next on the signaling session we have Varuna Nangia who is talking about non-genetic drug adaptation to MAPK inhibitors in melanoma #SACB2025
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For our second invited talk in our signaling session, we have one Dr. Mike Lee talking about cell death and the Pol II degradation-dependent apoptotic response (PDAR) #SACB2025 @TheLeeLab
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To kick off our last session "Target Signaling Transduction" we have Dr. Rachel Gottschalk on mathematical modeling of signaling networks in macrophages #SACB2025
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For our second speaker on our special AI/Equity/Cancer session, we have Dr. Curtis Henry #SACB2025
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To kickoff our special session on Health Equity for AI in Cancer we have Dr. Tina Hernandez-Boussard #SACB2025
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Last talk of the systems pharmacology session at #sacb2025 is Emily Bozich identifying drug synergies using network topologies
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The #sacb2025 systems pharmacology continues with Leonard Harris with more microenvironmental interrogation of cancer growth
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Next up at #SACB2025 have @AndriyMarusyk discussing the evolutionary dynamics of cancer drug response
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Systems pharmacology session at #SACB2025 leads off with Marc Birtwistle from Clemson University
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The #SACB2025 immunology session closes out with @DavidESanin discussing myeloid cell regulation in prostrate cancer
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The immunology session at #SACB2025 continues with Adam Maclean discussing cell-cell interactions in tumor metastasis
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Day two of #sacb2025 kicks off with Paolo Provenzano from University of Minnesota discussing the immune response in pancreatic cancer
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Last speaker in our postdoc highlight session is Dr. Wei Hu #SACB2025 on reversible and irreversible resistance mechanisms and personalized treatment
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Now in the postdoc highlight session, Dr. Raghav Jain tells us about their work on AML using multiomics data from CPTAC4 #SACB2025
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An example on how the efficacy synergy framework MuSyC has been applied for a novel drug
doi.org/10.1073/pnas.2408889…
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An impressive result from their work - their model would have been able to predict from single treatment trials what would have happened in the combination trials
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Dr. Amy Pomeroy @AmyEPomeroy is up next in our postdoc spotlight session telling us about their work on mechanistic modeling of combination therapy
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Our cancer metabolomics session continues with Dr. Bethany Veo who will talk about recurrent medulloblastoma that is resistant to radiation #SACB2025
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Dr. Cholsoon Jang @cholsoon_jang up next in the metabolism session with a talk on metabolism rewiring in liver cancer and ferroptosis #SACB2025
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Dr. Chandrasekaran @sriram_lab on how other omics can be used to predict the metabolome in cell lines using Recon8D biorxiv.org/content/10.1101/…
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Dr. Sriram Chandrasekaran @sriram_lab kicking off the Metabolism at Scale session with a talk on heterogeneity in cancer metabolism in EMT and beyond #SACB2025
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Last speaker in the tumor heterogeneity session at #sacb2025 is Michelle Barbeau studying EMT via proteogenomic approaches
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A fascinating observation - are many of the copy number-amplified oncogenes in extra chromosomal DNA?
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Next up at #sacb2025 is Elizabeth Brunk presenting on the use of AI in predicting cancer mutation function and on the world of extrachromosomal DNA
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Our next invited speaker at #sacb2025 is Dr. Soledad Sosa discusses cancer cell dissemination and its contribution to tumor in breast cancer and beyond
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Dr. Pamela Becker, after showing how systems biology can be used for individualized risk assessment with mmSYGNAL (doi.org/10.1101/2024.04.01.2…). A reminder that the future is now for systems biology applied to cancer! #SACB2025
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Dr. Pamela Becker showing us results from a clinical trial in which a functional assay to drug response results in better survival for patients with acute leukemia #SACB2025
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Dr. Pamela Becker kicks off the tumor heterogeneity session with her talk on AML drug resistance #SACB2025
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From the genomics of multi-site PDAC tumors, they find co-ocurring mutations in the MAPK/ERK pathway (which have been associated to KRAS inhibitor resistance) in addition to the KRAS mutation, whose presence varied between sites
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Keynote Christine Iacobuzio-Donahue believes that “systems approaches are the future of cancer research” and introduces her work in pancreatic cancer #SACB2025
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Our keynote speaker, Christine Iacobuzio-Donahue, reminding us that even though we know much about the genomic landscape in primary PDAC tumors, there are many gaps in our understanding of its evolution and metastases #SACB2025
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