A Laboratory of Systems Pharmacology
UMass Med School
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I really enjoyed this "Snippet" about our recent paper describing PDAR.
lifescienceeditors.com/2025/…
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Michael J. Lee retweeted
BE Seminar Series returns with @TheLeeLab, @UMassChan “Life, Death, and the Discovery of the Pol II Degradation-dependent Apoptotic Response (PDAR)” 32-141, 4p, 10/2 ow.ly/WiQh50X5aLh
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Michael J. Lee retweeted
Now online! RNA Pol II inhibition activates cell death independently from the loss of transcription dlvr.it/TMWhrz
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We just posted a preprint about a death mechanism that we find truly surprising.
When you turn off transcription, cells die (duh!) but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!
preprint here and a thread (1/n): biorxiv.org/content/10.1101/…
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The answer is about analytical resolution!!! The way we measure drug responses makes drug-induced growth rates and death rates very clear. More conventional approaches just can't see these distinctions clearly, masking this crazy phenotype. (8/end)
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We spent a lot of time trying to rationalize this through the decay rates of certain transcripts/proteins, but it never worked. The big 'ah-ha' was when we noticed that variation in death kinetics was perfectly coupled to variation in theloss of the inactive form of Pol II (3/n)
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Michael J. Lee retweeted
Please RT! We are officially accepting applications to the @UW Pharmacology PhD program!
Are you excited about doing a PhD in a cutting-edge, multidisciplinary community that spans all levels of pharmacology? Come join us!
Deadline is Dec. 1.
pharmacology.uw.edu/graduate…
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The SACB Abstract deadline is this Friday. This is an awesome community and always a very engaging meeting. Join us in Colorado this February!
Abstracts are due this Friday for #SACB2025! A great meeting for those who are employing systems approaches in cancer. We have an incredible array of speakers and a fantastic new location near Denver, Colorado.
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Michael J. Lee retweeted
Systems approaches to cancer biology meeting (SACB2025) is coming up! The abstract deadline and application to be part of our SACB 2025 Scholar program is Friday, November 1. Check out the details at sacbmeeting.org
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Michael J. Lee retweeted
Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - cell.com/cell-reports-medici…. The whole thing started when Karl and Jung-Kuei were trying to figure out hiow limiting dNTPS skewed DNA repair. Never thought it would be RNA and tge ribosome!
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Michael J. Lee retweeted
Congratulations to our 2024 medicine laureate Victor Ambros ✨
This morning he celebrated the news of his prize with his colleague and wife Rosalind Lee, who was also the first author on the 1993 'Cell' paper cited by the Nobel Committee.
#NobelPrize
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Michael J. Lee retweeted
Victor R. Ambros, PhD, @UMassChan's Silverman Chair in Natural Sciences and professor of molecular medicine, has won a Nobel Prize. Media: Email UMassChanCommunications@umassmed.edu for news conference info and interview requests. #NobelPrize #BreakingNews #AdvancingTogether
ALT Congratulations to Nobel Prize winner Victor R. Ambros, PhD, of UMass Chan Medical School
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Michael J. Lee retweeted
1/ 📢 Our special issue on #celldeath is now live @NatureCellBio, which features Editorial, Reviews, Perspective, Comment, Research Highlights, Research Articles and so many more!
👉Click and enjoy the reading: nature.com/collections/fffdb…
nature.com/articles/s41556-0…
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Bonsai Bar event at @RR_BrewingCo last night to celebrate @meganhoneywell and her amazing career in the Lee Lab @UMassChan @UMassChanGSBS. before & after pics of my bonsai included. no idea what i'm doing, but the folks at Bonsai Bar did their best with my lack of ability.
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