Professor at MIT, Surgeon-Scientist. DNA damage signaling, protein kinases, precision cancer medicine, signaling in tumor microenvironment
Boston, Massachusetts
- Tweets 137
- Following 126
- Followers 902
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Michael Yaffe retweeted
Scientists and universities: defend indirects as a concept but not current indirect rates. Don't think there's waste in those numbers? We (US science) spend $4.5 billion on journals. That is HALF of the proposed cuts in indirects, and eliminating that spending would make science better!
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Special thanks to Adam Palmer's lab, Matt Vander Heiden's lab, Omer Yilmaz's lab, and the folks at Genentech, all of whom were instrumental in this 5-FU story about RNA damage! Collaborative science is always the best!
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Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - cell.com/cell-reports-medici…. The whole thing started when Karl and Jung-Kuei were trying to figure out hiow limiting dNTPS skewed DNA repair. Never thought it would be RNA and tge ribosome!
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nature.com/articles/s41587-0…
Thrilled to share this latest work led by Xiao-Kang Lun in Peng Yin's lab and Xueyang Yu in mine. Finally, single cell signaling can begin to rival single cell RNA-Seq, using CyTOF, phospho-antibodies and ACE amplification.
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Michael Yaffe retweeted
This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promoted a culture where the primary goal of science is to produce bloated Nature papers that require lots of time and money, but little thought, to produce.
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Thrilled to share our characterization of the human tyrosine kinome.
Try out the public website: kinase-library.mit.edu/home
Wonderful collaboration with @CantleyLab @benturklab @LabYaffe. Many years of work led by Jared Johnson!
nature.com/articles/s41586-0…
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This is a really important thread from Lior Pachter about the mathematical underpinnings of scRNAseq.
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Michael Yaffe retweeted
Links between translation and alternative polyadenylation in metastasis? The story is out today! A great collab between @genophoria, @AndreiGoga_SF and @FKHM labs! Shout out to co-authors @Gentremet, @JulianeScience, @lisacfishsci among others! nature.com/articles/s41556-0…
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Very grateful to our collaborators at Genentech, Adam Palmer's lab, @ac_palmer, Matt Vander Heiden's lab, @mvh_lab, and Omer Yilmaz's lab @ohyilmaz, and of course the Koch Institute! @kochinstitute
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In the bioRxiv paper, we find that 5-FU shows no synergy at the cellular level with the DNA damaging drugs oxaliplatin or irinotecan - the combination given for GI cancer Rx. Instead, ribosome and tRNA biogenesis is impaired, driving an apoptotic signal that does not require p53
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RNA Damage? Happy to share Jung-Kuei Chen and Karl Merrick and @LabYaffe preprint that reports the major mechanism of 5-FU action in clinically relevant cancer treatment is through damage to structured RNAs...biorxiv.org/content/10.1101/….
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Michael Yaffe retweeted
Great work from the @davidkcortez lab!
doi.org/10.1126/science.add7…
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Congrats to Justine Stehn, Scott Floyd, and Yi Kong on what I hope will be the first of a series of papers showing alterations in protein translational control after DNA damage through stress signaling and 14-3-3. frontiersin.org/articles/10.…
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Michael Yaffe retweeted
Despite our scientific success @novonordiskfond will close CPR due to new funding strategy. #forskpol #DKforsk
We applaud our visionary leader Jiri Lukas for creating a global flagship in protein research whose pioneering spirit will live on #CPRlegacy. How did he do this? 👇🧵
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