YaffeLab@LabYaffe

The Yaffe Lab at the @kochinstitute, @MITBiology, and @MITdeptofBE | Interested in kinase signaling and precision medicine | Account is run by lab trainees

 Cambridge, MA
yaffelab.mit.edu/
Joined August 2020
22 Photos and videos
Happy Halloween! 🎃 We are celebrating Yaffe lab style, with some tricks (Tiffany's cool data) and treats (candy and donuts) 🍬
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Prost! 🍻 October isn't truly over in the lab until we go out and celebrate Oktoberfest! 🇩🇪
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Check out one of the most recent articles from @MIT news, in which they interviewed our very own UROP Charvi Sharma about her research in the lab and her experience as a Course 6-7 major: news.mit.edu/2023/giving-stu…

Giving students the computational chops to tackle 21st-century challenges

MIT’s four blended majors give students a solid grounding in computational fundamentals, such as coding, algorithms, and ethical AI, while enabling them to tackle hard problems in fields like...

news.mit.edu
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Happy Friday science twitter! The official™️ Yaffe lab social media manager went on a brief hiatus to do experiments, but we are back with another Friday profile! This week, we caught up with Alex Kruswick, a PhD student
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Question 3: If you could be any lab instrument, what would it be and why? The PCR machine (including a tube of NEB HiFi/Gibson Assembly Mix and Q5 Polymerase). Q5 is a cheat code and Gibson Assembly is an incredibly powerful tool that has enabled my research to happen.
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You can check out Alex's work done with @BertKooij and @haicovanattikum here: nature.com/articles/s41467-0…
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New pre-print from the lab! Fanconi anemia proteins not only repair DNA interstrand crosslinks, but also DNA double-strand breaks. Great work by @BertKooij, Fenna van der Wal, in collaboration with @marcelvanvugt, @altmeyerlab and @LabYaffe! biorxiv.org/content/10.1101/…

The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombi...

Homologous Recombination (HR) is a high-fidelity repair mechanism of DNA Double-Strand Breaks (DSBs), which are induced by irradiation, genotoxic chemicals or physiological DNA damaging processes....

biorxiv.org
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For the sake of gender balance, up next for a #Yaffelab Friday profile is our own @Jpatterson____, who is a research scientist in the lab!
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Question 3: If you could be any lab instrument, what would it be and why? The deconvolution microscope, because it readily generates beautiful images and the math behind it is really quite amazing.
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You can read all about Jesse's work here: cell.com/cell-systems/fullte… aacrjournals.org/cancerres/a…

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

We identified the combination of TH588 and Plk1 inhibition as synergistic for the killing of tumor cells, but not normal cells, and used a combined experimental and computational method to identify...

cell.com
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Our last feature of August is of our terrific lab tech, Robin Lu!
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Question 3: If you could be any lab instrument, what would it be and why? A cell sorter. I've used them a lot and it still blows my mind that they can do what they do.
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Tune in next week for another profile! Robin will be applying to Ph.D. programs in the fall - she is an amazing scientist, and we can't wait to see where she lands!
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