The Yaffe Lab at the @kochinstitute, @MITBiology, and @MITdeptofBE | Interested in kinase signaling and precision medicine | Account is run by lab trainees
Cambridge, MA
Based in United States
- Tweets 105
- Following 64
- Followers 400
- Likes 71
Happy Halloween! 馃巸 We are celebrating Yaffe lab style, with some tricks (Tiffany's cool data) and treats (candy and donuts) 馃崿
2
9
2,526
Happy Friday science twitter! The official鈩笍 Yaffe lab social media manager went on a brief hiatus to do experiments, but we are back with another Friday profile! This week, we caught up with Alex Kruswick, a PhD student
1
5
1,093
For the sake of gender balance, up next for a #Yaffelab Friday profile is our own @Jpatterson____, who is a research scientist in the lab!
1
3
360
To kick off this Friday, we are bringing you another lab profile of Tiffany's bay mate and Yaffe lab PhD student-turned-postdoc Tatiana Netterfield (@scientist_tati)!
1
3
13
2,871
In anticipation for the new academic year, every Friday we will do a profile on a Yaffe lab member so you all can get to know us! To kick this off, we are starting with Tiffany Emmons, who is a postdoctoral associate in the lab馃
1
13
2,548
Our very own minuteman, Tom Dietzel (pictured in a revolutionary war-era uniform), recently gave the lab a tour of the Freedom trail in Boston, and it was a blast! We hope everyone has a safe and BBQ-filled 4th of July! 馃巼馃嚭馃嚫
7
425
@Jpatterson____ popping bottles to celebrate his picture making the cover! 馃嵕
Read the article from @LabYaffe behind this month's cover: Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill #CancerCells of Disparate Origins Independently of Androgen Receptor Signaling.
bit.ly/406N2nn
@MIT
2
36
Check out our latest paper in @CR_AACR! Not only did it get published - but we also scored the cover pic for this issue (馃槑), which shows pHH3 staining in patient-derived xenograft samples. Congrats to @Jpatterson____ and the boss @mbyaffe for this amazing body of work!! 馃コ
3
6
29
2,534
Group pic before getting 馃崷 to send off our terrific undergraduate student Alexandra as she goes back to George Washington University! If you need someone to juggle 15 cell lines at a time, she's your girl 馃槑
19
Congrats to the newly minted Dr. Molly Bird, who just successfully defended her PhD in @MITdeptofBE on RNA binding proteins yesterday! We can't wait to see what you accomplish next! 馃帀
1
2
27
We were then able to validate the synergy of abiraterone and a Plk1 inhibitor both in non-prostate cancer cells, as well as in two xenograft-based mouse models AND in a PDX model of prostate cancer
1
1
We also found that the combination of abiraterone with a PLK1 inhibitor led to mitotic arrest and then a subsequent wave of apoptotic cell death
1
Live cell imaging experiments then revealed that both AR-targeting drugs abiraterone and enzalutamide induced mitotic spindle defects independent of AR-status
1
1
RNA-seq then revealed a synergy-specific signature consisting of genes related to mitosis and the mitotic spindle
1
1
Nothing like soaking up the sun between sessions at the DNA repair #GRC 馃尀You can chat with @yiwenkong1, @mbyaffe, and Alex to get the inside scoop on what we have been up to in this area! 馃馃К
8
In this year's lab Yankee Swap, everyone was really trying to get this special @mbyaffe-wrapped gift, any guesses to what was inside? Wrong answers only馃槀
2
1
8