Associate Professor of CV Medicine, @UniBergamo - ASST PG23 Bergamo. Dyspnea-HFpEF-PH-PVD, RHC-echo-(i)CPET.
Milan, Lombardie
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Ever wondered what determines the hemodynamic impact of tricuspid regurgitation?
What is the impact of RegVol/RegFr on RA V waves and on stroke volume? What the impact of RA compliance on RA V waves?
Can we safely use indirect Fick in tricuspid regurgitation?
@CircHF
🧵👇
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Sergio Caravita retweeted
Deeply grateful to the collaborators who brought physiology, engineering and computational biology in PH-HFpEF.
Moving beyond PVR to build a patient-specific map of where disease lives across the heart–pulmonary circulation. ahajournals.org/doi/full/10.…
@uw_medicine @UWCVRC @CircHF
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Sergio Caravita retweeted
V0 anchors the ESPVR, and needs to be reported with Ees for meaningful, reproducible pressure–volume analysis @j_hausleiter @BrenerMickey
ahajrnls.org/4xw4r92
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Echocardiography can measure RV-PA coupling in patients with TR, but it should be done properly, using physiologically sound parameters that are not necessarily the easiest to obtain
Right Ventricular–Pulmonary Artery Uncoupling in Secondary Tricuspid Regurgitation:
Invasive Validation of Echocardiographic Surrogates
onlinejase.com/article/S0894…
spoiler: sorry for TAPSE/PASP...
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Sergio Caravita retweeted
Research Article by C Baratto et al. (@GParati22 @CaravitaSergio) Invasive #exercise #hemodynamics in obstructive and nonobstructive hypertrophic #cardiomyopathy
ow.ly/2njt50ZqThk
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Right Ventricular–Pulmonary Artery Uncoupling in Secondary Tricuspid Regurgitation:
Invasive Validation of Echocardiographic Surrogates
onlinejase.com/article/S0894…
spoiler: sorry for TAPSE/PASP...
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Invasive exercise hemodynamics of obstructive vs non-obstructive hypertrophic cardiomyopathy
@japplphysiol
journals.physiology.org/doi/…
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Sergio Caravita retweeted
Thrilled to have been a part of this project with @IvanDulanMDPhD and @FudimMarat.
Bedside IVC echo can rapidly distinguish autonomic dysfunction-predominant orthostasis from RV failure in patients with LVADs without invasive testing. @JACCJournals #JACC
jacc.org/doi/10.1016/j.jacca…
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New in #EHJVSHD
In this 🇧🇪multicenter CPETecho study from @JessaZiekenhuis and @ZOLziekenhuis 🇧🇪, we evaluated whether exercise PH in significant primary mitral regurgitation is better assessed by the mPAP/CO slope than by peak exercise sPAP alone. 🧵1/7
@ESC_Journals #VHD
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Ever had a pt with isolated PH with normal wedge and PVR? - ie ‘unclassified PH’. In a multicohort analysis we show that HFPEF is the most common cause of PH with no obvious cause, warranting hemodynamic stress testing. @CircHF @MayoClinicCV
ahajournals.org/doi/10.1161/…
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Is sotatercepts benefit all cardiac in PAH? We find evidence of probable autonomic modulation with associated blunted ventilatory drive to CO2 after sotatercept. This may contribute to improved dyspnea beyond hemodynamic changes
publications.ersnet.org/cont…
@MayoClinicCV
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Sergio Caravita retweeted
Although HFpEF started out hypothesized to be a complex heterogeneous disease, we may have been guilty of mistaking different stages of the same disease for different phenotypes. HFpEF might be as simple as HFrEF after all. @JACCJournals @MayoClinicCV
sciencedirect.com/science/ar…
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Hemodynamic-Driven Staging of Heart Failure With Preserved Ejection Fraction Using Unsupervised Cluster Analysis
Machine learning applied to rest and exercise hemodynamic data highlighted the transition from L to R heart phenotype in HFpEF
onlinelibrary.wiley.com/doi/…
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Sergio Caravita retweeted
#RightVentricular Contractile Reserve in Heart Failure With Preserved Ejection Fraction
ahajournals.org/doi/10.1161/…
#HFpEF #RV @CircHF @denisamuraru
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RV Contractile Reserve in HFpEF - 3D echo & RHC study
Key points:
latent RV dysfunction may be frequent (49%) and associated with:
- worse rest & exercise hemodynamics
- HFpEF-ABA & NTproBNP
- TR RegVol
... also non-severe TR may matter!
@CircHF
ahajournals.org/doi/full/10.…
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Sergio Caravita retweeted
For this @JournalASEcho report, we sought to validate right ventricular stroke volumes and tricuspid regurgitant volumes measured by 3D echo.
Then we compared the quantitative metrics used to assess TR severity. Read our JASE report: bit.ly/4cgMZh4
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Sergio Caravita retweeted
Just published in Circulation- a multi-institution collaborative team effort that leverages insights from invasive cardiopulmonary exercise testing to further understand HFpEF. lnkd.in/eVuF7SkF
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#SimPub #ACC26 In the CADENCE phase 2 trial of patients with combined pre- and post-capillary pulmonary hypertension, sotatercept reduced pulmonary vascular resistance compared with placebo over a 24-week treatment period. @RyanTedfordMD @mardigomberg ahajrnls.org/4rZBW0g
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Sergio Caravita retweeted
#Editorial #ACC26 Re Maitland et al. ahajrnls.org/4rZBW0g
CADENCE Trial: Sotatercept in combined pre & post-capillary PH from HFpEF. A new therapeutic frontier for a population with significant unmet need. ahajrnls.org/4dL5HOQ
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History is made…
#SimPub #ACC26 In the CADENCE phase 2 trial of patients with combined pre- and post-capillary pulmonary hypertension, sotatercept reduced pulmonary vascular resistance compared with placebo over a 24-week treatment period. @RyanTedfordMD @mardigomberg ahajrnls.org/4rZBW0g
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