INR/Clinician scientist @inselgruppe @ScanNeuroradBE | Neurovascular Research Team | Stroke
Bern
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Johannes Kaesmacher retweeted
For stroke patients that can directly undergo EVT, is IVT before EVT cost effective? Find out more in this great work by Chi Nguyen and the IRIS collaboration.
neurology.org/doi/10.1212/WN…
@GreenJournal ,@manonkappelhof ,@kiliantreurniet ,@CheesemakerMD ,@FishingNeurons
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Johannes Kaesmacher retweeted
We are hiring a Postdoc.
Join the Pragmatic Evidence Lab @ Uni Bern.
Apply now.
ohws.prospective.ch/public/v…
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Johannes Kaesmacher retweeted
Recanalization Is Not the End of the Story: What Early MRI Reveals About Hypoperfusion After Thrombectomy
In this #BloggingStroke post, @karishma_popli discusses #Stroke article by ter Schiphorst et al. #ISC26 @AHAScience
ahajournals.org/do/10.1161/b…
ALT Graphic abstract in ter Schiphorst et al.
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Johannes Kaesmacher retweeted
The January episode of the #StrokeAlert Podcast is now available. In this episode, host @NAsdaghi highlights articles in the January issue of #Stroke and interviews @fwcavalcante & Prof. Charles Majoie about the IRIS meta-analysis. ahajournals.org/do/10.1161/p…
ALT Stroke Alert Podcast logo
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Johannes Kaesmacher retweeted
Amazingly executed Michele! It's great to see growing evidence for the DOT ⚪️ Also thanks to @DOWindecker for his hard work on the inital DOT paper @StrokeBern @CheesemakerMD @TDobrocky @Eikeip @TotoMynell @DavidSeiffge @FishingNeurons
9/ 🇮🇹 Final note
Kudos to Valentina Tudisco, Prof. Toscano stroke team @unimessina , and the @AUSLRomagna neuro & NRI team!
💡and kudos to @adnan_mujanovic @CheesemakerMD @FishingNeurons and @StrokeBern team for describing DOT first!
Read the full study jnnp.bmj.com/content/early/2…
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Johannes Kaesmacher retweeted
Why some #stroke patients worsen despite apparently successful thrombectomy?
👉 Focus: the Distal Occlusion Tracker (DOT) sign on post-MT flat-panel CT
🔰a thread on our newly published study in @JNNP_BMJ
jnnp.bmj.com/content/early/2…
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Johannes Kaesmacher retweeted
🚀Breaking news🚀We would like to welcome the @DOIT_trial study teams in Ulm, Leipzig, Ludwigshafen, and Bad Neustadt to the @DOIT_trial community!🥳 we are thrilled to have you on board, actively screening and recruiting patients!
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Johannes Kaesmacher retweeted
This topical review by Campbell et al. discusses the optimization of #stroke reperfusion trials, key imaging research priorities, and improved definitions for macro vs microvascular reperfusion. ahajournals.org/doi/full/10.…
@GeorgeHarston @PoojaKhatriMD @FishingNeurons @NguyenThanhMD
ALT Graphic abstract in Campbell et al.
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Johannes Kaesmacher retweeted
Presented at #SVIN25:
CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: nej.md/3LK9kst
Editorial: Managing Asymptomatic Carotid Stenosis nej.md/482XjG1
@svinsociety
ALT The Society of Vascular and Interventional Neurology 2025 Annual Meeting Original Article | NOV 21, 2025 | NEJM.org Medical Management and Revascularization for Asymptomatic Carotid Stenosis Figure 2A. Primary-Outcome Analysis. The NEJM signature sits at the bottom.
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Johannes Kaesmacher retweeted
🧠Study of patients who underwent intracranial stenting after EVT found no differences between those with vs. without IVT in:
🗓️90-day mRS shift
🗓️90-day mortality
🕐 24h sICH rates
Read more here👇
journals.sagepub.com/doi/abs…
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Johannes Kaesmacher retweeted
Excelente oportunidade e grande iniciativa!! 👏👏👏 @sheilambrasil @FishingNeurons
📣 Calling all stroke specialists in Latin America!
Join us in São Paulo, Dec 2–5 2025, for the first Latin America Stroke Summer School from University of Bern in partnership with Rede Brasil AVC and ESO, endorsed by WSO.
🎥 Check out Urs Fischer’s invitation and get ready for this groundbreaking event!
🔗 strokersummeravc.com.br | #AVC #Stroke @RedeBrasilAVC
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Johannes Kaesmacher retweeted
The DO-IT study is gaining momentum in Europe, and Canada is next! 🇨🇦 Are you ready to DO IT? 👍💪💉
🔊 Exciting DO-IT Trial Update!🔊
📈 🌍 The trial continues to expand, with 24 sites actively recruiting across Europe and 33 patients enrolled so far!
- 27 in🇨🇭
- 3 in the 🇳🇱
- 2 in 🇧🇪
- 1 in 🇪🇸
👏 A big thank you to everyone contributing!
💉🧑⚕️Recruit. Care. Cure. DO-IT!
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Johannes Kaesmacher retweeted
In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone.
DO NOT ADD ASS TO (D)OAC for chronic CAD
nejm.org/do/10.1056/NEJMdo00…
Original Article: Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC trial) nej.md/45AU4Wp
#Cardiology
ALT Kaplan–Meier curves for a composite of cardiovascular death, myocardial infarction (MI), stroke, systemic embolism, coronary revascularization, or acute limb ischemia (the primary efficacy outcome)
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Johannes Kaesmacher retweeted
🔊 Exciting DO-IT Trial Update!🔊
📈 🌍 The trial continues to expand, with 24 sites actively recruiting across Europe and 33 patients enrolled so far!
- 27 in🇨🇭
- 3 in the 🇳🇱
- 2 in 🇧🇪
- 1 in 🇪🇸
👏 A big thank you to everyone contributing!
💉🧑⚕️Recruit. Care. Cure. DO-IT!
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Johannes Kaesmacher retweeted
Cancer-related strokes are difficult to manage, synonym of bad prognosis and still poorly understood, which is why I did my clinical PhD on this exciting topic.
It is now published online, check it out!😉: boristheses.unibe.ch/6822
@StrokeBern @MedFacultyUniBE
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Johannes Kaesmacher retweeted
Excited to see our work "SWICH - a fully automated deep learning model for CT-based ICH segmentation" presented by @bmsiepen at the World Stroke Conference 2025 in Barcelona! 🎉
Open-access software available - contact our team to collaborate or try it out.
#WSC2025
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Johannes Kaesmacher retweeted
🚨new paper!
Should stroke patients with tandem lesions undergo stenting during EVT? And does prior IVT matter?
Find out below 👇
ahajournals.org/doi/10.1161/…
#stroke
@manonkappelhof @kiliantreurniet @CheesemakerMD @FishingNeurons
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Johannes Kaesmacher retweeted
Please apply
📢 Postdoc opening working with routine health data and clinical trial data in Bern, Switzerland. The candidate should also have interest in meta-research. See jobs.apps.be.ch/job-vacancie…
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Johannes Kaesmacher retweeted
This graph sums it up. In acute stroke with tandem lesions (ICA + intracranial occlusion), acute carotid stenting during EVT was associated with better 90-day outcomes than EVT without stenting.
Outcomes were similar with or without prior IV thrombolysis (IVT).
Caveat: secondary (post-hoc) IPD meta-analysis of 6 RCTs - stenting wasn’t randomized, so results are associative, not causal.
Acute Carotid Stenting for Tandem Lesions in Patients Randomized to Endovascular Treatment With or Without Thrombolysis: Results From the IRIS Individual Participant Data Meta-Analysis | Stroke ahajournals.org/doi/10.1161/…
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