ChemBioChem@ChemBioChem

Showcasing breakthroughs at the interface of chemistry & biology #ChemBioChem. We have changed our X account. Find our latest updates on @ChemEurope.

 Weinheim, Germany
chembiochem.org/
Joined June 2012
4,118 Photos and videos
Thank you for your support! We will no longer post from this account. To keep up to date with the latest news, follow us on @ChemEurope!
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Tumor Acidity-Triggered Bioorthogonal Reactions for Biomedical Applications (Y. Yuan et al.) onlinelibrary.wiley.com/doi/…

Tumor Acidity‐Triggered Bioorthogonal Reactions for Biomedical Applications

Tumor acidity and bioorthogonal reactions have been widely utilized in tumor diagnosis and therapy over the past years. Herein, we provide an overview of the concept and major strategies of tumor...

chemistry-europe.onlinelibrary.wiley.com
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Dual-Targeting of the HER2 Cancer Receptor with an Antibody-Directed Enzyme and a Nanobody-Guided MMAE Prodrug Scaffold (K. V. Gothelf et al.) #openaccess onlinelibrary.wiley.com/doi/…
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Accessing Active Fragments for #DrugDiscovery Utilising Nitroreductase Biocatalysis (J. Reynisson, A. Winter, S. C. Cosgrove et al.) #openaccess onlinelibrary.wiley.com/doi/…

Accessing Active Fragments for Drug Discovery Utilising Nitroreductase Biocatalysis

Holder et al. show a promiscuous nitroreductase biocatalyst can afford access to a panel of functionally diverse aniline fragments. These have been shown to be active in biological assays, offering...

chemistry-europe.onlinelibrary.wiley.com
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We are switching Social Media accounts, and we will no longer post news from this account. Please follow us on @ChemEurope to keep up with the latest updates!
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Short Oligourea Foldamers as N- or C-Caps for Promoting alpha-Helix Formation in Water (G. Guichard, M. Pasco et al.) #openaccess onlinelibrary.wiley.com/doi/…

Short Oligourea Foldamers as N‐ or C‐Caps for Promoting α‐Helix Formation in Water

Locked at either end: The high helix propensity of short oligourea sequences allows efficient capping at both the N- and C-terminus of water-soluble peptide sequences. This extra-helical stabilizat...

chemistry-europe.onlinelibrary.wiley.com
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A Dual Bispecific Hydrolysis Peptide-Drug Conjugate Responsive to Micro-Acidic and Reduction Circumstance Promotes Antitumor Efficacy in Triple-Negative Breast Cancer (X. Zhu et al.) onlinelibrary.wiley.com/doi/…

A Dual Bispecific Hydrolysis Peptide‐Drug Conjugate Responsive to Micro‐Acidic and Reduction...

A bispecific hydrolysis PAP-SS-PTX prodrug is synthesized by conjugating PTX into PAP peptide via disulfide and ester bonds. The prodrug could release active drug molecule (PTX) under co-stimulation...

chemistry-europe.onlinelibrary.wiley.com
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#OnTheCover Design, Synthesis and Catalytic Activity of Protein Containing Thiotyrosine as an Active Site Residue (ChemBioChem 17/2024) (V. Torbeev et al.) onlinelibrary.wiley.com/doi/…
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Delighted to see this work spotlighted on such a nice cover!
ChemBioChem@ChemBioChem
4 Sep 2024
#OnTheCover Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial Properties (A. Frei et al.) @DCBPunibern onlinelibrary.wiley.com/doi/…
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ChemBioChem retweeted
ChemMedChem@ChemMedChem
5 Sep 2024
Congratulations and a big thank you to the #EFMCISMC24 @EuroMedChem scientific committee, local organizers, EFMC Council, Volunteers, and LDO for a fantastic meeting in Rome, and for featuring @ChemEurope, @ChemBioChem & @ChemMedChem as true partners. Until the next meeting!
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Freezing Functional Nucleic Acids: From Molecular Reactions to Surface Immobilization (B. Liu et al.) onlinelibrary.wiley.com/doi/…

Freezing Functional Nucleic Acids: From Molecular Reactions to Surface Immobilization

Freezing aqueous solution of functional nucleic acids can accelerate reactions across different scales mainly via the freeze-concentration effect. These reactions include molecular ligation and...

chemistry-europe.onlinelibrary.wiley.com
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A Metastable Semiquinone Molecular Switch Modulated by Ascorbate/O2: A Study from a System Far-From-Equilibrium to Biological Assays in Mitochondria (L. Chacon-Garcia et al.) onlinelibrary.wiley.com/doi/…

A Metastable Semiquinone Molecular Switch Modulated by Ascorbate/O2: A Study from a System Far‐Fr...

Pyrrolyl quinone thiocyanate exhibits a switching behaviour between its metastable radical anion structure and its reduced form. The kinetically trapped structure enters a non-equilibrium state when...

chemistry-europe.onlinelibrary.wiley.com
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Biosynthesis of Halogenated Tryptophans for Protein Engineering Using Genetic Code Expansion (H. Xiao et al.) onlinelibrary.wiley.com/doi/…

Biosynthesis of Halogenated Tryptophans for Protein Engineering Using Genetic Code Expansion

The tryptophan halogenases SttH and RebH catalyze the halogenation of tryptophan at the C-6 and C-7 positions, respectively. By introducing the biosynthetic pathways for tryptophan halogenation...

chemistry-europe.onlinelibrary.wiley.com
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STING-Activating Small Molecular Therapeutics for Cancer Immunotherapy (L. Ren, H. Wang et al.) onlinelibrary.wiley.com/doi/…

STING‐Activating Small Molecular Therapeutics for Cancer Immunotherapy

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a potential target for cancer immunotherapy. Novel STING-activating small molecular therapeutics,...

chemistry-europe.onlinelibrary.wiley.com
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#OnTheCover Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial Properties (A. Frei et al.) @DCBPunibern onlinelibrary.wiley.com/doi/…
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Imidazoles are Tunable Nucleofuges for Developing Tyrosine-Reactive Electrophiles (K.-L. Hsu et al.) onlinelibrary.wiley.com/doi/…

Imidazoles are Tunable Nucleofuges for Developing Tyrosine‐Reactive Electrophiles

Herein, we developed a series of sulfonyl-azole (SufAz) probes to investigate chemical reactivity and applications for chemical proteomics. Our studies identified aryl sulfonyl imidazoles as a...

chemistry-europe.onlinelibrary.wiley.com
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Characterization of HphA: The First Enzyme in the Homologation Pathway of l-Phenylalanine and l-Tyrosine (S. Mori et al.) @AUG_University; @ShogoMori26 onlinelibrary.wiley.com/doi/…

Characterization of HphA: The First Enzyme in the Homologation Pathway of l‐Phenylalanine and...

Homologation of amino acid is an extension of the side chain, which is a relatively uncommon chemical transformation found in natural products and yet to be studied. The first secondary metabolite...

chemistry-europe.onlinelibrary.wiley.com
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ChemBioChem retweeted
The Frei Lab@TheFreiLab
3 Sep 2024
Nice to see the Cover Image for our recent @ChemBioChem paper out now! Full Paper here: doi.org/10.1002/cbic.2024004…
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Proximity-Dependent Activation of Split DNAzyme Kinase (M. Liu et al.) onlinelibrary.wiley.com/doi/…

Proximity‐Dependent Activation of Split DNAzyme Kinase

A proximity-dependent activation of split DNAzyme kinase with DNA phosphorylating activity (termed ProxSDK) was developed. When two independent fragments of the split DNAzyme kinase recognize and...

chemistry-europe.onlinelibrary.wiley.com
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Only 3 more week until @ChemBioTalks 2024!! An incredible line up of the best in #chemistry #syntheticbiology #chembiol #proteomics #naturalproducts , plus #earlycareer #PhD flashtalks! Thanks to @chembiochem @EFMC @UniLeidenNews @TU_Muenchen Free rego: web.cvent.com/event/7b3b6cdf…
Stephan Hacker (inactive account)@StephanHacker2
15 Aug 2024
I am very much looking forward to the 4th Virtual @ChemBioTalks with talks by @KateCarrollLab, Kai Johnsson @mpimoph, @Malins_Lab, @london_lab, @DerbyLabDuke, Sebastian Essig, @ChellanResearch and my personal highlight, the flash talks. Register for free: web.cvent.com/event/7b3b6cdf…
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