I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!

Today is a BIG day for @RocketPharma — and for my firm @CivilizationVC!!! An FDA approved drug. 🚀🧬 The FDA granted accelerated approval to Rocket gene therapy for the severe form of a rare immune disorder called leukocyte adhesion deficiency-I (LAD-I). "LAD-I is caused by mutations in the ITGB2 gene and leads the immune system to stop working properly. Patients with severe disease face serious and potentially deadly bacterial and fungal infections. Currently, the only potential cure is stem cell transplant from a donor, but that bears its own serious risks. The gene therapy involves extracting a young patient’s own blood stem cells and modifying them in the lab to introduce functional copies of the gene. Patients then receive conditioning to clear out their bone marrow, after which the modified cells are infused back in hopes of giving them a working immune system." Congratulations to the Rocket team on this milestone! FDA approves Rocket's gene therapy for ultra-rare immune disease - endpoints.news/fda-approves-…

Honored that @CivilizationVC — the fund I founded barely 8 years ago as a solo GP in the heavily conservative #lifesciences space — has now cracked the Top Quartile as a force in #biotech! No other firm of our size + vintage came even close. Thanks @JohnCendpts and @endpts for the analysis. OrbiMed jumps to number one on the top 100 list of biotech venture investors - endpoints.news/orbimed-jumps…

We opened trade at $100 a share for @BillionToOneInc

The big day is here - we’re ushering in a new era with @omadahealth’s IPO at @Nasdaq! I’m honored to stand with the founders - @seanduffy, Adrian and Andrew on this momentous day! From first angel to an institutional investor via my firm @CivilizationVC - we’ve come full circle! Omada’s going to “bend the curve” in helping solve chronic disease.

The official @PitchBook panel group photo, collector’s edition.

CEO Tamer Mohamed (@_tamerm) will present at the 42nd Annual J.P. Morgan Healthcare Conference. #JPM24 📅 Thu, Jan 11, 9:30am PT 📍 San Francisco, CA Learn more: buff.ly/3S5rfdO

📢 We have a *big* announcement at @CivilizationVC -- the first of 3 promised announcements by year end. 🥁 I'm delighted to introduce you all to our new Investment Partner Dr. Sonia Setayesh! @soniasethh 🧬Sonia is a passionate researcher and investor who joins us with a #PhD out of @USC where she did pioneering work in #cancer diagnostics and, before her PhD, in cell therapies. Learn more about Sonia and our mission to fund Essential Innovations on our newly updated website: civilizationventures.com/

(NEW EPISODE) He Raised $170 Million To Build UV-C Machines To Kill Pathogens And Save Lives cc @RZeroSystems alejandrocremades.com/he-rai… @SOSV @hax_co @QualcommVenture @upfrontvc @LaCDPQ @wilabcom @BMO @CivilizationVC @johndoerr @SwiftarcVC #business #success

We are excited to announce that we closed an oversubscribed Series B financing round of $58.75M. The financing was led by @ForesiteCapital with participation from @CivilizationVC , @BluebirdLifeSci, @pearvc , @agent_capital, @Stanford, @CUSystem. foresight-dx.com/news/foresi…