Group of UK scientists and international advisors aiming to advance research in cryobiology and cryonics. Our goal is to use technology to defeat death.
United Kingdom
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Cryonics: fantasy or a bridge to the future? #TEDtalks @imperialcollege @jpsenescence @TEDx piped.video/watch?v=d1xHpp4F…
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Supercooled kidneys have been transplanted into pigs in a “landmark achievement”
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Organ donation and brain preservation after assisted dying: case report and considerations for a potential pathway
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this is (to our knowledge) the largest cryo chemical campaign ever run!
we’ve physically screened over 7,000 new chemical entities, most of which were not previously associated with cryopreservation
last quarter, we did 2,943 formulation runs for biocompatibility, across a diverse panel of cell types
Come build the future with us 🙂
We’re making progress on one of cryobiology's biggest challenges: finding biocompatible cryoprotectants.
Our latest blog post dives into how we built our cryoprotectant discovery engine that scaled up the search from a few dozen candidate molecules to over 250,000, and is already producing hits.
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Overcoming Perfusion Impairment in the Ischemic Brain: A Review
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Cryopreservation of rat cortical cells for brain-on-chip research
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No, we're not on the brink of ending aging. More clickbait, even from prestigious scientific magazines that should know better.
Why not? A short 🧵
1) The strongest lifespan-extending intervention in mice is caloric restriction, discovered nearly a century ago. So even in animals we haven't truly made much progress on how to slow (much less reverse) aging.
2) Our understanding of the aging process and its cellular and molecular drivers is still poor - which helps explain 1).
3) There is no proven intervention that retards human aging itself.
Cellular reprogramming is an exciting technology with many companies* and labs now working on it. It may have important clinical applications, including the current clinical trial for glaucoma - fingers crossed!
But while reprogramming allows cells to be rejuvenated in vitro, we don't yet understand whether or how it can be used safely and effectively in whole organisms.
And rejuvenating cells isn't the same as rejuvenating an organism. Remember that an immortal cell is a cancer cell, so rejuvenating a cell may or may not be beneficial in an organism made of many different types of cells. We know from mouse experiments that reprogramming can induce cancer, so it needs to be carefully controlled and tailored to the tissue and context.
*Disclosure: I'm CSO of YouthBio, a company developing rejuvenation gene therapies based on cellular reprogramming.
Are We on the Brink of Ending Aging?
nationalgeographic.com/healt…
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Is Cryonics Even Legal? The Truth About Ethics, Law & Regulation lifeboat.com/blog/2026/07/is…
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Berkeley Biostasis Classification
zenodo.org/records/21514009
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How much investment will it take to develop a cure for human aging?
21%
<$100B
26%
$100B-$1T
36%
>$1T
17%
Not currently possible
329 votes • Final results
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🚨 FROZEN AFTER DEATH... WAITING FOR THE FUTURE
What if death is not the end, but a very long pause?
Baseball legend Ted Williams is preserved in liquid nitrogen at -196°C through a process called cryonics. Around 500 people worldwide have chosen the same path, hoping future science may one day bring them back to life.
The mystery? No cryopreserved human has ever been revived. Still, thousands are willing to take the chance.
Would you choose to wake up in the future?
Source:
Alcor Life Extension Foundation. Cryonics: Frequently Asked Questions. Alcor Life Extension Foundation.
ALT 🚨 FROZEN AFTER DEATH... WAITING FOR THE FUTURE** What if death is not the end, but a very long pause? Baseball legend Ted Williams is preserved in liquid nitrogen at -196°C through a process called cryonics. Around 500 people worldwide have chosen the same path, hoping future science may one day bring them back to life. The mystery? No cryopreserved human has ever been revived. Still, thousands are willing to take the chance. Would you choose to wake up in the future? **Source: Alcor Life Extension Foundation. *Cryonics: Frequently Asked Questions*. Alcor Life Extension Foundation.
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Question for people skeptical of cryonics:
What part do you find hardest to believe?
The future of medicine, the logistics, or the whole idea?
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Only true until we intervene in the ageing process.
Humans cannot fly, but technology has allowed us to overcome our natural limits 🚀
How long can humans live? All evidence points to a maximum of 125 years
nature.com/articles/d41586-0…
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Next-gen cryo promises transplant surgeons more time
nature.com/articles/s41587-0…
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Have we been looking at RNA changes during ageing the wrong way? 🧬
In our new study we use a largely overlooked technique called spike-in normalisation to investigate age-related changes in transcripts across mouse cell types.
A thread 🧵
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Wise words from Jennifer Doudna on AI in biology.
Biology is hard and complex. No big new ideas have come from AI yet. And while AI can make discovery more efficient, testing will still be required.
Above all, we need more and better data to build better models.
Jennifer Doudna won the Nobel Prize for gene editing and went on Bloomberg to say the chatbots everyone is betting on cannot innovate at all. Every promise Silicon Valley is making about AI curing disease just hit the one person qualified to check it.
She has spent her whole career inside the actual frontier of curing disease.
So when she talks about what AI can and cannot do in biology, she is not guessing. She is reporting from inside the lab.
Her words were blunt. She is not seeing chatbots innovate. They summarize data. They write reports. They do not come up with a brand new idea nobody has ever had.
Then the interviewer pushed. So you're saying AI can't innovate?
Doudna did not flinch. She does not know if it can't. She just does not see it doing it right now.
This lands harder when you remember who is making the opposite case. Sam Altman says AI will eliminate disease within five years. Larry Ellison says AI will cure cancer in a 48 hour window.
An OpenAI executive even floated that the company should get a cut of sales on any drug discovered through ChatGPT. Doudna answered that in two words. Good luck.
Even the cancer specialists Altman is selling to keep warning that cancer is not one disease but hundreds, each needing its own cure, and that compute does not skip the years of lab work.
Her reason is simpler. Biology is hard. You cannot simulate your way to an understanding of the human body.
The people promising cures are the ones selling the tool.
The person who actually won a Nobel building them is telling you it has not happened yet.
Source: Bloomberg Originals
Watch the full video on their official channel.
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Bridging the Gap in Cryopreservation: A Review of Cryoprotectant Innovation and Global Market Trends
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