Disease Models & Mechanisms - discovery for human health. A @Co_Biologists Open Access journal that publishes human disease research.
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ALT Call for papers - Special Issue - Paediatric Genetic Diseases: Models, Mechanisms and Therapies. Edited by James Amatruda, Ross Cagan and Elaine Mardis. Extended deadline: 7 December 2026.
ALT Protein–protein interaction (PPI) network of upregulated DEGs constructed using the STRING database
ALT Jay (left) and Liz (right) Scott.
ALT A) Image showing a trans-axial cross-section of a 9-month-old female Sost−/− mouse skull; the ossicles region of interest is highlighted in white within the boxed area. (B) Representative 3D microCT images of the ossicles in the middle ear of male (top) and female (bottom) BL6 (left) and Sost−/− (right) mice aged 9 months. Arrowheads indicate regions with a visible increase in bone.
ALT UBA1 knockdown reduces protein ubiquitination in Drosophila melanogaster and mouse skeletal muscles but primarily affects the levels of a limited set of proteins (‘UBA1-sensitive proteins’) that rely on optimal UBA1 levels for their turnover and stability.
ALT Schematics of the KrasG12D, Pik3caflox and Pik3caRBD alleles. Following tamoxifen administration, mice have either a single wild-type (Pik3cawt/Δ) or mutant Pik3ca allele (Pik3caRBD/Δ) in their LECs. They also express KrasG12D in their LECs.
