Dave Arnold@DaveArnoldLab

We are interested in motoneuronal maintenance and repair in health, aging, and disease. Translational NM physiology. PM&R, Neurology. @MUHealth @MizzouPMR

 Columbia, MO
davearnoldlab.com
Joined January 2013
116 Photos and videos
It is finally out! JCI - Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition jci.org/articles/view/190646
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Yesterday, I had the honor of sharing research from my lab as the 10th Dave Kilmer Memorial Lecture Speaker at UC Davis. Dr. Kilmer's pioneering work was a driving force behind my decision to pursue neuromuscular medicine as a career.
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Brian Thomas defends PhD thesis on Innovative Lung Cancer Therapies - MU School of Medicine medicine.missouri.edu/news/b…

Brian Thomas defends PhD thesis on Innovative Lung Cancer Therapies

(4/15/25) On Tuesday, April 8, Brian Thomas, an MD-PhD candidate at the University of Missouri, successfully defended his PhD thesis in the Monsanto Auditorium at the Bond Life Sciences Center. The...

medicine.missouri.edu
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Dave Arnold retweeted
Niko McCarty.
@NikoMcCarty
10 Apr 2025
Beautiful paper. Scientists solved the structure of myosin—the protein that forms contractile filaments in muscle cells—in multiple configurations using Cryo-EM. They captured the entire power stroke action (where myosin pulls on actin to shorten the muscle) at4.4 Å resolution.
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Great presentation by @bthomasZOU congrats on an amazing body of work during your PhD training as part of the Tom and Anne Smith MD/PhD program.
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Strong work Joe! Representing our group at AANAM. Wish I could have joined.
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Excited and proud to share great news about Dr. Viteri’s recent grant. Strong work! Excited to see the impact that this work can have on increasing our mechanistic understanding of ALS and developing better treatments. americanbrainfoundation.org/…

Meet the Next Generation of Brain Disease Research - American Brain Foundation

Discover how this year's brain disease researchers are advancing diagnoses, treatments, and cures for all brain diseases and disorders.

americanbrainfoundation.org
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Summary - The Science of Aging: Combating the Onset of Age-Related Diseases events.nyas.org/event/aging2…
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Excited to share our recent pre-print @researchsquare: Targeting senescence in Amyotrophic Lateral Sclerosis: senolytic treatment improves neuromuscular function and preserves cortical excitability in a TDP-43Q331K mouse model. researchsquare.com/article/r…
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Team science is the best science. This is a great write up about a collaborative project triggered by a chance meeting during a virtual poster session at SFN. Plus there's more to come stemming this collaboration in the near future. carney.brown.edu/news/2025-0…

Weak signals, weak muscles

Researchers led by a team from the Carney Institute have discovered a new role for a protein that helps control muscle contractions – a finding that points to a new target for drugs that treat muscle...

carney.brown.edu
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Excited to share our new work investigating a neurotherapeutic approach for age-related loss of physical function just published in Geroscience. 5‑HT2C agonism asaneurotherapeutic forsarcopenia: preclinical proof ofconcept. rdcu.be/d6F30
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Dave Arnold retweeted
APSA@A_P_S_A
15 May 2024
⭐Calling all current & former MD/DO-PhD trainees: Tell us about your perspectives on and experiences with grant writing for a research study. You do not need to have submitted a grant to participate. Complete the survey here: redcap.link/0zurckyc #doubledocs #GrantFunding
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Brain-muscle communication prevents muscle aging by maintaining daily physiology science.org/doi/10.1126/scie…

Brain-muscle communication prevents muscle aging by maintaining daily physiology

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In...

science.org
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Excited for the opening of our new neuroscience research space in NextGen Precision Health and the addition of three soon to be be five new neuroscience PIs! showme.missouri.edu/2024/the…

The silent intruder

NextGen Precision Health neuroscientist Smita Saxena explores ALS's insidious path.

showme.missouri.edu
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Excited to see our team project online! Contributions of Mouse Genetic Strain Background to Age-Related Phenotypes in Physically Active HET3 Mice - ScienceDirect sciencedirect.com/science/ar…
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Excited to announce our new ALSA Trial Capacity Award which aims improve access to Clinical Trials in Missouri als.org/blog/breaking-down-b…
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NextGen Precision Health is growing awareness for the exciting research happening across Missouri at the Society for Neuroscience conference in Washington D.C. The UM System is well represented with 24 poster presenters and panelists! @SfNtweets #SfN23
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Dave Arnold retweeted
Patrick Hsu
@pdhsu
16 Nov 2023
The first approved CRISPR medicine in the world for sickle cell disease and beta thalassemia! A huge victory for biotechnology, patients, and humanity businesswire.com/news/home/2…
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Dave Arnold retweeted
Kathleen Sluka@ksluka0101
15 Nov 2023
Last day for #artofneuroscience ⁦@SfNtweets⁩ - come see all 12 artists and take home a unique neuroscience present. #neuroart
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Successful SFN! Great presentations by Anna Roshani Dashtmian and Fereshteh Babaei Darvishi @fereshtehbd
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