David Gokhman@David_Gokhman

Asst Prof @WeizmannScience. Studying how gene regulation has shaped human evolution. Especially fond of Neanderthals and Denisovans. david-gokhman.bsky.social

 Israel
gokhmanlab.com
Joined June 2012
23 Photos and videos
Humans are far more prone to degenerative skeletal diseases than other apes. Our new @Nature paper uncovers the genetic changes that shaped our skeleton and uncovers a major clue to why it is so vulnerable to degeneration.🧵👇 nature.com/articles/s41586-0…
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Humans are far more prone to degenerative skeletal diseases than other apes. Our new @Nature paper uncovers the genetic changes that shaped our skeleton and uncovers a major clue to why it is so vulnerable to degeneration.🧵👇 nature.com/articles/s41586-0…
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Co-led with the wonderful @TakaInoue5 , and spearheaded by the super talented Yizhi Yan (experiments) and @nadavmishol (analyses), together with a fantastic team of collaborators.
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And for more on the genetics of skeletal evolution, check out the wonderful recent work from the Capellini lab lead by Alexander Okamoto pubmed.ncbi.nlm.nih.gov/4211…

In Vitro Massively Parallel Screening of Human Regulatory Elements Involved in Postcranial Skeletal...

Every element of the human skeleton exhibits some differences in comparison to our closest living relatives, chimpanzees. Many of these skeletal modifications underpin key events in human evolution,...

pubmed.ncbi.nlm.nih.gov
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Such a fantastic resource by @MKuhlwilm's lab. We’re using this catalog in half our projects nature.com/articles/s41597-0…

A curated dataset of great ape genome diversity

Scientific Data - A curated dataset of great ape genome diversity

nature.com
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Denisovans or their close relatives identified in the fossil record using a gene regulatory phenotyping method. Now out: pnas.org/doi/10.1073/pnas.25…
Credit: Maayan Harel

ALT Credit: Maayan Harel

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Our approach was based on gene regulatory phenotyping, which predicts the direction, rather than magnitude, of phenotypic difference - a much more attainable goal. If you're interested in why and how this approach works, see: nature.com/articles/s41467-0…

Predicting the direction of phenotypic difference

Nature Communications - Here authors reveal a method to predict key information on phenotypes - their direction. This is achievable even for phenotypes with incomplete genotype-to-phenotype...

nature.com
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It was a true pleasure to work on this with @nadavmishol , @lirancarmel , Gadi Herzlinger, Uzy Smilansky, and Yoel Rak.
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Given two genomes, can you tell who’s taller or more prone to a disease? How confident can you be? A fresh take on phenotypic inference, now out in @NatureComms : rdcu.be/exW4f See thread🧵👇:
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Importantly, unlike quantitative phenotypic predictions (e.g., based on polygenic scores), we show that our qualitative approach circumvents one of the biggest problems in population genetics – the limited transferability of genotype-phenotype association data across populations
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Overall, we suggest that substantially more phenotypic information can be inferred from genetic data than previously appreciated @GiliGreenbaum @ShaiCarmi and Keith Harris
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