Immunology/cancer researcher. Chair, Metabolism Dept at @VAInstitute @VAIMetabolism. Former @McGillU @UofT. GRR/YYZ. Opinions are my own
Grand Rapids, MI
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The Jones lab @VAInstitute is recruiting postdoctoral fellows interesting in studying how nutrition impacts anti-tumor immunity. vai.wd1.myworkdayjobs.com/en…
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How exercise decreases the risk of cancer and cancer- related mortality by reducing immunosenescence and inflammaging
sciencedirect.com/science/ar…
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Commentary on diet caloric restriction vs cancer nature.com/articles/d41586-0…
and importance of cancer metabolism statnews.com/2025/12/15/onco…
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How a restricted diet (DR) improves the immune response to cancer and success of immunotherapy in the experimental model. T cell metabolic reprogramming @NatMetabolism
nature.com/articles/s42255-0…
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Top #Citations 2025: 5️⃣
@VishwaDeepDixi1et al (@YaleMed) show that cysteine depletion leads to adipose tissue browning and rapid weight loss in mice and humans.
nature.com/articles/s42255-0…
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New! Online now: Restricting lipid accumulation in tumor-infiltrating neutrophils mediates caloric restriction-induced anti-cancer effects dlvr.it/TPlGV5
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Human gut M cells resemble dendritic cells and present gluten antigen @Nature @HansClevers
nature.com/articles/s41586-0…
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Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses go.nature.com/3YnywYB
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Happy to share our latest paper from Dr. Brandon Oswald (@BrandonOswald3) showing that dietary restriction (DR) restricts tumor growth by stimulating anti-tumor T cell responses. @VAInstitute @VAIMetabolism nature.com/articles/s42255-0…
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All in all, this work suggest that the anti-tumor effects of calorie restriction works in part by boosting anti-tumor T cell responses. Our study adds to the exciting new work out recently indicating that nutrition plays an important role in immunity against cancer.
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Nice job @BrandonOswald3. And thanks to everyone who contributed to this study, including our great collaborators @eclien @Tcellogic @ketonemics and @krawczyklab.
For more information, please read here: vai.org/article/study-reveal… @VAInstitute
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Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumor immunity and immunotherapy responses @NatMetabolism @DrRGJonesLab
@VAInstitute
nature.com/articles/s42255-0…
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Epigenetic scarring after chronic infection or cancer can lock immune cells into a dysfunctional state.
Here, @Hazemghoneim11 & team @OhioState develop an in vitro model of terminal CD8+ T cell dysfunction that better mimics in vivo exhaustion.
insight.jci.org/articles/vie…
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#GLP1 medicines now address weight loss and other health conditions through innovative formulations and expanded indications, highlighting key questions about their efficacy and safety.
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ALT JAMA article 'New Molecules and Indications for GLP-1 Medicines'. Diagrams show Semaglutide, Tirzepatide for approved medications, Retatrutide, Survodutide for emerging medications. Approved indications listed: obesity, type 2 diabetes, sleep apnea, etc.
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