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Investigators developed an accelerated #immunomodulatory matrix reservoir integrating methylgermanane nanosheets within an active Ca2+-crosslinked alginate hydrogel. ✨ 🔗 bit.ly/4yctMp0

Dr. Di Zhao and researchers reported that B7-H3 plays dual roles in regulating #MDSCs and cancer-associated fibroblasts (#CAFs), thereby promoting tumor progression and therapy resistance, respectively. 🔬 Learn more: bit.ly/4hjG87z

Aberrant tubular epithelial cell and immune-cell activation converges in the sustained activation of fibroblasts and the deposition of excess extracellular matrix, driving the progression of acute kidney injury to chronic kidney disease over time. Read the @nature study: go.nature.com/3SQAWjD Led by researchers at Helmholtz Zentrum München and Ludwig-Maximilians-University in Germany. #Nephrology #KidneyDisease #Fibrosis

A new review synthesizes mechanistic insights linking cathepsin D-mediated proteolysis to epithelial junction reorganization and permeability barrier recovery. It also highlights emerging therapeutic strategies for improving chronic wound healing. Read the review: bit.ly/4AgI1dS Research from Adichunchanagiri University, led by first author Shobith Rangappa and senior author Manjula Rv. #WoundHealing #Dermatology #CellBiology

Challenging the prevailing fibroblast-centric paradigm, investigators provide an overview of how non-fibroblast cell types engage in dynamic crosstalk and collectively shape the biochemical and biomechanical landscape of tumors. Led by first author Sonal Srivastava and corresponding author Antonio L. Amelio at Moffitt Cancer Center Tampa. Check out the full review here: bit.ly/4xmMs4j #ECM

Researchers discussed #epigenetic mechanisms controlling cancer cell-intrinsic states, cancer cell–TME crosstalk, current epigenetic therapies, and future research directions that may lead to the discovery of new biomarkers and the development of effective epigenetic anticancer therapeutics. ▶️ Check out this #OpenAccess review: bit.ly/3SAouEA

Dr. Morten Thaysen-Andersen and researchers reported on the mechanistic basis for and functional consequences of glycocalyx remodeling accompanying tumor-associated #macrophages polarization. Learn more: bit.ly/4cza9Pm

Emerging evidence indicates that diverse non-epithelial cell populations undergo a progressive reprogramming toward mesenchymal-like states during tumor progression. This review names this phenomenon #mesenchymal drift and underscores its significance for next-generation therapeutic strategies: bit.ly/4wLazcu

#LiverFibrosis is sustained by the dense #ECM produced by persistently activated hepatic stellate cells (aHSCs). In this study, researchers developed an aHSC-targeted nanoplex that disrupts the rigid ECM, offering a promising antifibrotic therapy: bit.ly/4qBOR9v

🤝 Single-nucleus transcriptomics meets single-cell transcriptomics in this new @CellStemCell paper that identifies stromal reprogramming as a mechanism governing hematopoietic niches. Take a look at the #OpenAccess paper: bit.ly/4zRb1cb #Myelofibrosis

Stay up to date with your field! 🔬 Subscribe to #ExtracellularMatrix News for free bi-weekly newsletters. 👇 bit.ly/4kkWMEu

#AdiposeTissue is now recognized as a dynamic endocrine organ that shapes cancer behavior. This new review from Dr. Hussein Sabit (@Must_University) looks at how cancer-associated adipocytes drive oncogenesis, progression, & therapeutic failure: go.nature.com/3UiG9kA

First author Ling Pan and collaborators from the Chinese Academy of Medical Sciences define a lncRNA-based regulatory checkpoint in which the SNHG26–PTBP1–AKT3 axis stabilizes #mesenchymal fibroblast identity and drives #ExtracellularMatrix accumulation. 🧫 Abstract: bit.ly/4xtnAJ9 📚: @PNASNews

The authors synthesize how cancer-associated #adipocytes and adipose dynamics drive #oncogenesis, progression, and therapeutic failure and highlight actionable nodes within the adipose–tumor axis for precision oncology. go.nature.com/3UiG9kA

Scientists examine the integration of 3D bioprinting with decellularized ECM (dECM) for tumor modeling, with particular emphasis on dECM sourcing, processing methodologies, and biofabrication parameters—and their collective influence on model fidelity. bit.ly/4hWR3Gy

Danielle Klunk, Laura Homewood, and Daniel Abebayehu use #hydrogels to mimic physiological stiffnesses and examine how mechanical and biochemical #ECM cues influence progesterone-induced differentiation (decidualization) in healthy fibroblasts. bit.ly/4gF5Gfo Read the #OpenAccess article in @iScience_CP. 🔓

Emerging evidence indicates that diverse non-epithelial cell populations, including #macrophages, endothelial cells, pericytes, adipocytes, and fibroblasts, undergo a progressive and often partial reprogramming toward #mesenchymal-like states during tumor progression. Learn more in @iScience_CP: bit.ly/4wLazcu

New findings from @FudanUniversity reveal a neutrophil-mediated mechanism driving surgical liver regeneration and support the potential of CD177+ neutrophil infusion to establish a proregenerative environment for #LiverFailure therapeutic strategies. ⚗️ bit.ly/4wJmAPZ

New findings provide preclinical evidence that a thiol-rich immunomodulatory hydrogel can combine physical barrier function with microenvironmental regulation to support endometrial regeneration. Learn more: bit.ly/4qwOEoc #EndometrialFibrosis

Drs. David Kaplan (@TuftsUniversity) and Gordana Vunjak-Novakovic (@GVNlab) have defined the hallmarks of #fibrosis across organ systems to establish foundational design criteria necessary for modelling human fibrosis in vitro. Abstract: go.nature.com/45uJv6p