We study how cells sort important stuff around their insides and to their outsides | Golgi aficionados | @Cornell & @CornellMBG | Tweets by lab members
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Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @ryan_vignogna about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!
Mind the GAP 🚧🕳️🚧
Excited to share the latest preprint from the @Fromme_Lab showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵:
biorxiv.org/content/10.64898…
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Fromme Lab retweeted
Really proud of this paper just out in JCB. At almost every turn, SURF4 surprised us. Amazing PhD student, @jmaldutyte, sleuthed it out.
rupress.org/jcb/article/224/…
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Awesome new paper from @Fran_Bottanelli lab!
ARF1 compartments direct cargo flow via maturation into recycling endosomes
nature.com/articles/s41556-0…
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Fromme Lab retweeted
Columbia will award the 2024 Louisa Gross Horwitz Prize to Scott Emr and Wesley Sundquist for discovering the ESCRT pathway and revealing how it works.
Read more: columbiamed.link/47uD4jS
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Fromme Lab retweeted
Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute.
Please share and apply!
academicjobsonline.org/ajo/j…
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Fromme Lab retweeted
New preprint. More on non-canonical motifs for DDR kinases.
Here we find that Tel1 (yeast ATM) targets D/E-S/T.
... more prevalent than S/T-Q
... NOT shared with Mec1.
May explain how Tel1 plays specialized roles in DNA repair and telomere maintenance.
biorxiv.org/content/10.1101/…
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Big congratulations to @ryan_vignogna on his NIH F32 Postdoctoral Fellowship award!!!
F32 NOA ✔️
Very grateful for mentors @jcfromme & @gregoryianlang and thankful to work in such an awesome place @weillinstitute @Fromme_Lab
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Fromme Lab retweeted
Final version of our latest Kramer story is out! Congrats to @Hongyan_S for leading this effort & Adnan, Dylan, Alessandro, & @nicobuchon too! Read on to learn how Wnt signaling in surprisingly many cell types promotes stem cell proliferation in the gut: sciencedirect.com/science/ar…
New preprint: It's about a gene called Kramer 😉 that controls #WntSignaling & stem cell proliferation in the fruit fly intestine. Congrats to @Hongyan_S @weillinstitute & @nicobuchon @cornellento @cihmid! cc: @SeinfeldTV @Seinfeld2000 @JerrySeinfeld doi.org/10.1101/2023.02.21.5… 1/n
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Super impressive membrane-bound Arf1-AP3 cryoEM structures from the Baker lab!🤩
Check out the latest work from my lab, courtesy of soon-to-be Dr. @Biochem_Batman , who determined multiple #cryoEM structures of the human AP-3 adaptor complex. This was a years-long effort to reconstitute active Arf1-AP3 complexes on lipid nanodiscs biorxiv.org/content/10.1101/…
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lab alum @FeathersRyan is a DRaGoN master
Dream team Rish and @FeathersRyan giving a cryoDRGN❄️🐉 lecture and tutorial at #CryoNet in Stockholm! 🤩
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Fromme Lab retweeted
Happy to share the newest preprint from @HollopeterLab @cornellvet: biorxiv.org/cgi/content/shor…. We propose the Inversin complex works via a dimerization mechanism. You’re probably thinking, “What the $%@! is the Inversin complex?” Let me explain:
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Fromme Lab retweeted
I'm so excited to finally share the results of my PhD work! Check out this thread for all of the highlights!
Ric1-Rgp1-Rab6 has been the most difficult #cryoEM project I've worked on so far, but I'm so happy with how it came together and what we learned about Rab6 activation!
We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)
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Fittingly, the URL for the new AlphaFold3 server is:
GOLGI.sandbox.google.com
#GolgiTime
*apparently it also works for proteins that do not localize to the Golgi, although we don't know why anyone would use it that way
Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/go…
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We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)
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Taken together, our findings allow us to model the orientation of Ric1-Rgp1 on the Golgi membrane and understand how it activates Rab6. (8/9)
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@ryan_vignogna provided important contributions after @FeathersRyan started his postdoc training with @ZhongingAlong and @HughsonLab. We are grateful for help from @cryomariena and @ktspoth with #cryoEM data collection. #GolgiTime (9/9)
bioRxiv: tinyurl.com/mrk2wk72
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