Bioorthogonal chemist, cell biologist, #chembio & #lipidtime enthusiast, occasional classical pianist. Also @jeremybaskin.bsky.social
Ithaca, NY
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Thrilled to share this #lipidtime story in @JCellBiol where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. hubs.la/Q04mQjrC0
@basktastic @weillinstitute @CornellChem
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How do plant organs stay smooth—or become wrinkled? 🌱 Our paper in @CurrentBiology shows how coordinated growth direction and mechanical properties across cell layers determine whether Arabidopsis sepals remain smooth or buckle.
cell.com/current-biology/ful…
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Fantastic talk today on biophysical imaging of mycomembranes by @jcslab at @CornellPathogen!
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What if tissues have a lipidomic architecture of their own?
We mapped the mouse brain lipidome and revealed distinct “lipizones”. They are not simply a reflection of cell identity but capture anatomy and cellular processes.
A new way to think about how lipids organize tissues.
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery?
Join our amazing faculty at the @weillinstitute at @Cornell University in Ithaca, New York.
academicjobsonline.org/ajo/j…
Apply by Nov. 15!
Please share!
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Our new paper revealing the link between cholesterol and the clearance and recycling of damaged mitochondria is now published in @NatureComms! Congrats to @YHaoning & Koji @NTUsg who led the study, and thanks to Aik Yong & @Isaspore @NUSMedicine for CLEM! nature.com/articles/s41467-0…
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Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv
nature.com/articles/s42255-0…
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If you are preparing a presentation, by far the most effective, concrete tip is to ensure each slide title is a complete sentence. Subject, verb, object. That ensures each slide has 1. at least one point, 2. no more than one point—i.e., each slide has exactly one point! :)
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Stanford Bioengineering faculty search: Apply by Sept 30!
Bioengineering is defined broadly: if you are engineering at the level of biomolecules, cells, tissues, organisms, or using/developing advanced engineering techniques to study these systems - please apply!
facultypositions.stanford.ed…
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We have a new assistant professor position in the @weillinstitute on Biomedical and Translational Sciences. Come join us! apps.hr.cornell.edu/recruiti…
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‼️P2A sometimes does not work‼️
Our new co-first-author paper is out in Nucleic Acids Research!
We unexpectedly found that nascent-chain sequences located well upstream of P2A—even outside the ribosomal exit tunnel—can modulate peptide-bond skipping efficiency. 1/n
academic.oup.com/nar/article…
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Our new co-first-author paper is out in Nucleic Acids Research!
We unexpectedly found that nascent-chain sequences located well upstream of P2A—even outside the ribosomal exit tunnel—can modulate peptide-bond skipping efficiency. 1/n
academic.oup.com/nar/article…
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Nearly a decade ago, Niyi and I began exploring photocatalysis to map protein spatial organization. Our new @Nature paper shows how protein proximity can reveal therapeutic target pairs and guide multispecific medicines.
nature.com/articles/s41586-0…
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Thrilled to be back in Dresden, the magnificent epicenter of #lipidtime research, for the @EMBO #LipidCodeToLife meeting — finally, lipids get to take center stage!
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NEW PREPRINT! Excited to share our first paper on steroidal bifunctional probes! We synthesized a library (14) of bifunctional (diazirine/alkyne) steroidal probes by systematically varying the position and connectivity of the key functional handles. (1/4) chemrxiv.org/doi/full/10.264…
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New in @CellCellPress from Biohub Investigator @BoHuangLab: AI-designed proteins built from scratch (dubbed "Rhobins") work in living cells and match or even surpass fluorescent tags refined over decades of natural protein engineering.
Read the paper: cell.com/cell/fulltext/S0092…
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Come be my colleague! @CornellChem is hiring TWO tenure-track faculty: assistant professor in chemical biology and open rank in quantum materials. Applications due Oct 15 — academicjobsonline.org/ajo/j… #chemjobs
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Change the textbooks. Trans-splicing as a means to diversify the proteome. Many congrats to Ruaidhri Jackson and Olivia Venezia on this remarkable discovery.
nature.com/articles/s41586-0…
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Excited to share our latest work, led by Surbhi Sharma! We study the kinetics of RNA localization to the outer mitochondrial membrane (OMM), building on our 2019 APEX-seq work showing that hundreds of RNAs go to the OMM for local translation. biorxiv.org/content/10.64898…
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