Studying intracellular lipid transport. NTUsg LKCMed, Yasunori Saheki lab.
Singapore
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YANG HAONING retweeted
LC3 forms functional nanoclusters on autophagosomes: link.springer.com/article/10…
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New research led by #LKCMedicine Assoc Prof Yasunori Saheki reveals how cholesterol protects cells' recycling centers during mitophagy and converts leftover fats into energy. Could offer new insights into neurodegenerative diseases! 🧬👇
lnkd.in/gyGv2zDZ
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Excited to share this! Lysosomal membrane cholesterol is important for lysosomal function and lipid recycling during mitophagy. Thank you Koji, my co-first author, and all co-authors, @ysaheki for the mentorship, and Aik Yong & @Isaspore @NUSMedicine for the beautiful CLEM!
Our new paper revealing the link between cholesterol and the clearance and recycling of damaged mitochondria is now published in @NatureComms! Congrats to @YHaoning & Koji @NTUsg who led the study, and thanks to Aik Yong & @Isaspore @NUSMedicine for CLEM! nature.com/articles/s41467-0…
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YANG HAONING retweeted
An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate. From Joshua Pemberton, John E. Burke, Tamas Balla and colleagues: hubs.la/Q04w6rkV0
📕 From our #Lipid and #Membrane collection: hubs.la/Q04w6BwR0
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YANG HAONING retweeted
Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases: Immunity cell.com/immunity/fulltext/S…
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YANG HAONING retweeted
Cholesterol enhances lysosome-autophagosome fusion for better α-synuclein clearance in GBA L444P-mutated Parkinson disease dlvr.it/TTvv7M
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YANG HAONING retweeted
A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER, which converts small lipid changes into a cooperative transcriptional response.
biorxiv.org/content/10.64898…
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YANG HAONING retweeted
🎓 Congratulations to our #LKCMedicine PhD by Research graduates from the #NTUsgClassof2026! Discover how Dr Konstanze Tan and Dr Sara Tasnim turned curiosity into research that advances healthcare. 🔬 Read more: ntu.sg/PhDGrad2026
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YANG HAONING retweeted
Myeong and Klyachko demonstrate that astrocytic cholesterol release modulates synaptic transmission in an activity-dependent manner to fine-tune the balance and spatial organization of different forms of synaptic exo- and endocytosis. hubs.la/Q04rQ2zD0
#Neuroscience
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YANG HAONING retweeted
🔬☀️smURFP is extremely photostable!☀️🔬
A comparison of mEGFP & smURFP photostability when fused to lifeact to image F-actin for 7 min on the Nikon SoRa.
doi.org/10.1038/s41467-023-3…
doi.org/10.1038/nmeth.3935
#FluorescenceFriday #Microscopy #SuperResolution
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YANG HAONING retweeted
Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting. From Dávid Kovács, Bruno Antonny and colleagues: hubs.la/Q04p9_r50
📕 Part of “Collective Behaviors and Self-Organization in Cells”: hubs.la/Q04p9Rnm0
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YANG HAONING retweeted
Today @NatureCellBio, we present a current view of lysosomal biology in aging and evaluate emerging therapeutic strategies. It has been a remarkable group effort from @AgingPitt.
Free PDF here rdcu.be/ftToj
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YANG HAONING retweeted
Universal cell embedding provides a foundation model for cell biology | Nature nature.com/articles/s41586-0…
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YANG HAONING retweeted
Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites dlvr.it/TTP8c7
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YANG HAONING retweeted
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. hubs.la/Q04mQjrC0
@basktastic @weillinstitute @CornellChem
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YANG HAONING retweeted
SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism dlvr.it/TTCSMY
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YANG HAONING retweeted
新しい論文が@ScienceMagazineに掲載されました！神経組織でオートファジーを自在にオン/オフできるマウスを開発し、一度抑制したオートファジーを再開することで、神経細胞の異常や脳機能障害の回復を実証しました。江口さん、おめでとうございます！science.org/doi/10.1126/scie…
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YANG HAONING retweeted
mRAVE governs lysosomal catabolism through basal and mTORC1-regulated V-ATPase assembly | The EMBO Journal | Springer Nature Link link.springer.com/article/10…
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YANG HAONING retweeted
Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome | Nature Cell Biology nature.com/articles/s41556-0…
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