Structural basis of peptide-mediated protein communication and function @HebrewU Member of @RosettaCommons. Tweets by lab members. 🦋 furmanlab.bsky.social 🦋
Jerusalem, Israel
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AlphaFold3 is out (and closed source 🤯😠)! So … how well does it do on peptide-protein complexes?
A continuing thread as we run predictions...
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🚨 actifpTM is now in AF3 🚨
Since our new metric, actifpTM, was determined to be the best for predicting success in designed proteins refolded by AF2 (biorxiv.org/content/10.1101/… by @TimothyPJenkins), we made it available also in AF3!
Our work on refining AlphaFold2’s ipTM has been accepted for publication in Bioinformatics @OxfordJournals
We have been questioning why ipTM worsens when docking peptides with disordered flanking regions, and modified the calculation to remove this effect.
Let’s dive in! 👇
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If you want to integrate it in your own AF3 installation, check the 3 files which only need a slight modification (model.py, confidences.py and confidence_types.py):
github.com/Kuhlman-Lab/alpha…
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Ora Furman Lab 🎗 retweeted
🚨The Bits to Binders Competition has concluded!🧬
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
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Ora Furman Lab 🎗 retweeted
1/13 🧵 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
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Ora Furman Lab 🎗 retweeted
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
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🚨Excited to share our new work in Cell Reports!
We reveal how SARS-CoV-2 nucleocapsid protein (NP) directs complement attack on uninfected cells, a surprising immune evasion twist.
🔗 cell.com/cell-reports/fullte…
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💡 Heparin analogs (like Enoxaparin) block NP surface binding, preventing immune complex formation and rescuing cells from complement attack.
A possible path to reduce immunopathology.
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This was an amazing collaboration with the @lab_wiener and @RouvinskiLab - thank you! 🙌
Graphical abstract below ⬇️
#SARSCoV2 #COVID19 #Virology #CellReports #ComplementSystem #Immunology
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Ora Furman Lab 🎗 retweeted
Our paper is out on biorxiv! Very excited to share our results - we find signal peptides might be structurally important for quite a few protein isoforms. Full thread soon!
Signal peptides as potential structural modulators of human splice isoforms biorxiv.org/content/10.1101/… #biorxiv_bioinfo
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Ora Furman Lab 🎗 retweeted
If you missed out on Sarel Fleishman's extraordinary talk last night, have no fear - you can check out the recording 👇
piped.video/2aaWh8yVq8U
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Starts in 10 minutes! This will be exciting, join us!
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvardo Valverde (@imbmainz).
Register to attend:
tinyurl.com/PMCseminar2
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Come join for this exciting talk!
Remember to tune in at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvarado-Valverde (@imbmainz).
Register to attend:
tinyurl.com/PMCseminar2
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Ora Furman Lab 🎗 retweeted
Remember to tune in at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvarado-Valverde (@imbmainz).
Register to attend:
tinyurl.com/PMCseminar2
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvardo Valverde (@imbmainz).
Register to attend:
tinyurl.com/PMCseminar2
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Ora Furman Lab 🎗 retweeted
Either if you attended or wanted but could not - please tell us how it works for you!
Thanks to everyone who has attended the PMC seminars!
We have decided to review the timing of the seminar series. If you have any thoughts about the timing of the seminars (currently 6-7pm CET every 2nd Mon of the month), please fill out this form: forms.gle/VZkU2fWkswxYbrZf8
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Ora Furman Lab 🎗 retweeted
Remember to join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@UofT) and Dr. Veronica Venafra.
Register to attend: tinyurl.com/register-pmc-sem…
You can find recordings of previous seminars here: piped.video/@PMCModularity
Join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@UofT) and Dr. Veronica Venafra.
Register to attend: tinyurl.com/register-pmc-sem…
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