Nature-Springer journal publishing cutting-edge research in #geroscience, from molecular/cellular mechanisms of #aging to translational and clinical studies.
United States
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💪 What drives age-related handgrip weakness?
A new study by Gregory M. Shaw and colleagues investigates the neural contributions to age-related declines in handgrip strength using multi-finger force deficit and dual-task testing.
The findings provide new insight into how neural factors may contribute to age-related muscle weakness, highlighting the importance of looking beyond muscle strength alone to better understand the mechanisms underlying physical decline with aging.
📖 Read the full article: rdcu.be/14c4oXDp6Kma
#GeroScience #Aging #MuscleAging #HandgripStrength #Sarcopenia #NeuromuscularAging #HealthyAging #AgingResearch
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🔬 LAPTM5, RPE senescence, and subretinal fibrosis: uncovering a potential mechanism of aging-related retinal changes
A new study by Xiaowei Yang and colleagues investigates the role of LAPTM5 in retinal pigment epithelium (RPE) senescence and subretinal fibrosis.
The study identifies the LAPTM5–WWP2–OPTN mitophagy cascade and cGAS/STING activation as potential mechanisms linking LAPTM5 to these age-related retinal changes, providing new insights into the molecular pathways involved in retinal aging.
📖 Read the full article: rdcu.be/5etK9qNXby4a
#GeroScience #Aging #RetinalAging #RPE #CellularSenescence #Mitophagy #cGASSTING #Fibrosis #AgingResearch
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GeroScience retweeted
The Biomarkers of Aging Conference at Harvard Medical School. I am speaking on Oct 6 about "The Year in Aging Clocks". What moved in the field this year and what did not? Program here: agingconsortium.org/2026-con…
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Launching "Healthspan for All" at the Translational Longevity Summit, Oct.7-11, One Milestone, Enterprise Research Campus at Harvard linkedin.com/pulse/launching…
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GeroScience retweeted
Colleagues from @metabesity and @APACLongevity are hosting the 2026 Asia-Pacific Healthy Longevity International Summit, Oct 1-4 in Hong Kong, with 1,000+ attendees and speakers including our Scientific Advisors, @mkaeberlein and @AndreaBMaier. Learn more: apaclongevitysociety.org/#/m…
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Longevity has no shortage of exciting ideas. The harder question is: what does the evidence actually support?
In my Q&A with Future Biotech Expo, I discuss biological age testing, AI, cognitive health, preventive medicine, and where longevity science may be heading.
Full Q&A: lnkd.in/gwZJ5KKy
#Longevity #LongevityScience #Biotech #PreventiveMedicine
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new Impetus Grants round announcement by @NornGroup, read more here, and contribute:
The next breakthroughs in biological AI will be shaped by the datasets we build now.
We’re planning an Impetus Grants @impetusgrants round to fund shared, AI-enabling biological datasets.
Learn more and contribute: norn.group/impetus-grants#:~…
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Scientists with bold ideas shouldn’t have to play it safe to get funded.
So we started giving “big if true” grants via @NornGroup to support intellectual risk-taking & help scientists explore ideas they wouldn’t otherwise get to try.
How has that been going? Extremely well! 👇
🔥Does academia stifle creativity? This new perspective argues that academia is currently structured to select against creativity, intellectual risk-taking and bold ideas. Young scientists – who may be best positioned for new ideas – are particularly incentivized to play it safe.
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Congratulations to the symposium awardees!
Heidi Pak (UT SW Medical Center) & Matt McDougal (OMRF) received the John R. Sokatch Excellence in Research.
Jillian Cox (OU Health) & Clara Hibbs (OU Health) received the OKNSC Outstanding Poster Presentation.
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GeroScience retweeted
I've focused for 25 years on aging damage repair, many of them while it was viewed as unscientific. Not any more! In December I oversee the Friday program at the Trampoline Zermatt Summit, with about 100 founders, investors and scientists. 2-6 December, by invitation.
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🧠💼 New research in GeroScience!
How does workplace stress influence healthy aging?
In a new study, Péter Varga & Zoltan Ungvari and colleagues examine workplace stress and healthy aging, outlining assessment strategies and research hypotheses and presenting pilot insights from the Semmelweis study.
The authors explore how workplace stress may be investigated in relation to biological, psychological, and functional dimensions of aging, providing a framework for future research into the relationship between working conditions, stress, and healthy longevity.
📖 Open access: rdcu.be/fYPoY
#GeroScience #Aging #HealthyAging #WorkplaceStress #OccupationalHealth #Stress #Longevity #Healthspan #AgingResearch
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🧠 Beyond gait speed: a multidimensional motor signature of Motoric Cognitive Risk Syndrome
A new study by Baptiste Perthuy & Leslie M. Decker and colleagues explores how domain-specific anomaly detection can identify a multidimensional motor signature of Motoric Cognitive Risk (MCR) syndrome, moving beyond gait speed alone.
The findings highlight the potential value of examining multiple aspects of motor function to better characterize motoric changes associated with cognitive risk.
📖 Read the full article: rdcu.be/WNR4Z
#GeroScience #Aging #MotoricCognitiveRisk #CognitiveAging #Gait #MotorFunction #Neuroscience #Gerontology
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📢 New research in GeroScience!
Can targeting cellular senescence help protect bone health during chemotherapy?
In a new study, David J. Izquierdo and colleagues investigated whether targeting cellular senescence could mitigate chemotherapy-induced bone loss in both young and aged mice.
The findings suggest that senescence-targeting strategies may help counteract chemotherapy-associated skeletal deterioration, highlighting cellular senescence as a potential contributor to treatment-related bone loss across different ages.
📖 Read the full article: rdcu.be/vix4V
#GeroScience #Aging #CellularSenescence #BoneHealth #BoneAging #Chemotherapy #Senolytics #HealthyAging #AgingResearch
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🦗 New research in GeroScience!
What can grasshoppers teach us about longevity and reproductive aging?
In a new study, Kerri Conklin and colleagues investigated the relationship between intermediate leucine catabolism, longevity, and sustained reproduction in grasshoppers.
The findings suggest that differences in leucine metabolism are associated with both longer lifespan and maintained reproductive function, offering new insights into the metabolic pathways that may contribute to healthy aging and longevity.
📖 Read the full article: rdcu.be/TqMmu
#GeroScience #Aging #Longevity #HealthyAging #AgingResearch #Metabolism #Leucine #ReproductiveAging #Healthspan
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❤️ New research in GeroScience!
Can targeting PCSK9 help protect the heart from alcohol-induced dysfunction?
In a new study, Csaba Matyas & Pal Pacher (@PacherPal) and colleagues investigated the effects of PCSK9 inhibition on alcohol-induced cardiovascular dysfunction.
The study links hepatic lipid accumulation with impaired myocardial contractile reserve and finds that PCSK9 inhibition attenuates these cardiovascular effects, providing new insights into the liver–heart connection and potential therapeutic mechanisms.
📖 Read the full article: rdcu.be/up3D4
#GeroScience #Aging #CardiovascularHealth #HeartHealth #PCSK9 #LipidMetabolism #LiverHeartAxis #HealthyAging
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🐭 New review in GeroScience!
How can frailty be assessed more effectively in naturally aged mouse models?
In a new review, Fujue Ji, Sihan Li, and Lei Yang examine current approaches to frailty assessment in naturally aged mice, including existing classification methods, their limitations, and priorities for future research.
The review highlights the importance of developing reliable and standardized frailty assessments that better capture the complexity of aging and improve the translational value of animal models in geroscience research.
📖 Read the full article: rdcu.be/rcRXC
#GeroScience #Aging #Frailty #Healthspan #Geroscience #AgingResearch #AnimalModels #PreclinicalResearch
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🧠💪 New research in GeroScience!
Can the biological aging of muscle be reflected in the aging brain?
In a new EEG study, Federico Frasca & Fabrizio Vecchio and colleagues investigated how muscle age acceleration relates to resting-state brain connectivity in older adults.
The findings provide new insights into the muscle–brain connection, suggesting that accelerated muscle aging may be associated with changes in functional brain network organization.
📖 Read the full article: rdcu.be/ewuA4
#GeroScience #Aging #HealthyAging #BrainAging #MuscleAging #MuscleBrainAxis #Neuroscience #EEG #Healthspan
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🚶♀️ New research in GeroScience!
Can reactive agility and motor-cognitive performance help identify older adults at risk of falls?
In a new dual-centre cross-sectional study, Florian Giesche and colleagues examined reactive agility and motor-cognitive performance in community-dwelling older adults with and without a history of falls.
The findings provide new insights into how combined motor and cognitive assessments may help distinguish older adults with a history of falls and contribute to a better understanding of fall-related functional changes.
📖 Read the full article: rdcu.be/XQzk
#GeroScience #Aging #HealthyAging #FallsPrevention #FallRisk #OlderAdults #MotorCognition #FunctionalAging #Gerontology
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❤️ New research in GeroScience!
How might sodium-glucose cotransporter 2 (SGLT2) inhibitors influence cardiovascular signaling in ischemic cardiomyopathy?
In a new study, Rosalinda Madonna and colleagues investigated the effects of SGLT2 inhibitors on circulating activin A and BMP/activin signaling in patients with ischemic cardiomyopathy and a high echocardiographic probability of pulmonary hypertension.
The findings suggest that SGLT2 inhibitor use is associated with lower circulating activin A and modulation of BMP/activin signaling, providing new insights into potential mechanisms underlying their cardiovascular effects.
📖 Read the full article: rdcu.be/txENB
#GeroScience #Aging #CardiovascularAging #IschemicCardiomyopathy #SGLT2Inhibitors #PulmonaryHypertension #CardiovascularHealth #HealthyAging
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